The goal of this study was to investigate the efficacy of
Syzigium cumuni seeds in the treatment of diabetes, as well as their potential
effects on male reproductive physiology and histopathology in Swiss albino mice
(Mus musculus), as well as various Indian herbal plants used in the treatment
of hyperglycemia complications, particularly in India. By injecting Alloxan
monohydrate into a male Swiss albino, I was able to induce a diabetic state. To
examine their restorative capacity, a fixed amount of Syzigium cumuni seeds
powder was supplied with food. Hyperglycemia is a serious human illness that
affects people from all walks of life in a variety of countries. Hyperglycemia
is a metabolic disease characterised by persistently elevated blood sugar
levels. Urination is frequent, thirst is increased, and appetite is increased.
Either the pancreas does not create enough insulin or the body's cells do not
respond to insulin effectively. Damage to blood vessels, cardiovascular
illness, impairment to the eyes (retinopathy), and kidney damage are all major
long-term risks (nephropathy). Despite the fact that there are a variety of
techniques to reducing its negative effects and problems, herbal treatments are
favoured owing to their low cost, ease of availability, and lack of side
effects. In the treatment of hyperglycemia, a list of medicinal plants with
established antihyperglycemic effects is used. Babul (Acacia Arabica), neem
(Azadirachta indica), gurhal (Hibiscus rosa-sinesis), bitter gourd (Momordica
charantia), giloy (Tinospora cordifolia), methi (Trigonella foenum-graecum),
and jamun (Trigonella foenum-graecum) are among them (Syzigium cumuni).
Syzigium cumuni, also known as jamun, jambul, black plum, or
Indian black berry, is a member of the Myrtaceae family. The presence of
anthocyanin, particularly in the peel regions of the fruit, gives it a pleasing
colour. There is only one seed in each berry. Syzigium cumuni is a common
medicinal plant used to treat diabetes and a variety of other ailments.
Anthocyanins, glucoside, ellagic acid, isoquercetin, kaempferol, myricetin, and
hydrolysable tannins are abundant in the plant (1-0-galloyl castalagin and
casuarinin). The alkaloid jambosine and glycoside jamboline found in the seeds
help to slow down the diastatic conversion of starch to sugar. In
alloxan-induced diabetic mice, the addition of ethanolic extract of seeds and
seed powder of Syzigium cumuni resulted in a considerable drop in blood sugar
levels and an improvement in pancreatic islet histology. There has also been a
decrease in glycosuria and blood urea levels. The seeds contain glucoside
jamboline, a phenolic substance, a trace of pale yellow essential oil,
chlorophyll, fat, resin, albumin, tannins (19%), phenolic compounds such as
ellagic acid, gallic acid (1-2%), caffeic and ferulic acids, and their
derivatives such as guaicol, resorcinol dimethyl ether, and corilaginin, as
well as phenolic compounds such as Protein and calcium are abundant in the
seeds. Flavonoids such as rutin and quercetin, as well as monoterpenoids such
as -pinene, -terpinene, terpinolene, borbeneol, -phellandrene, a-terpineol, and
eugenol. Syzigium cumuni also contains B-sitosterol (Black Plum seed).
Findings: The seed powder of Syzigium cumuni (Black Plum)
promotes pancreatic insulin secretion, which restores the histoarchitecture of
pancreatic -cells in experimental animal cells, indicating that it has
antidiabetic or antihyperglycemic properties. Its seed contains a variety of
phytochemicals such as triterpenes, anthocyanin, oleic acid, essential oils,
glycosides, saponins, and numerous Flavonoids that alter insulin resistance and
-cell function directly or indirectly.
Novelty: The discovery of such active molecules
has the potential to lead to the development of safer medications for the
treatment of a variety of disorders, including diabetes. Although the majority
of studies of Syzigium cumuni as an antidiabetic emissary with its possible
implemented actions and diabetes complications such as cataract, neuropathy,
and nephropathy have been conducted, more detailed research on the isolation of
bioactives through clinical trials followed by standardisation is urgently
needed to understand the plant's prospects. The presence of many phytochemicals
in Syzigium cumuni (Black Plum) seed, along with their documented modes of
action, indicates that some compounds target numerous metabolic pathways,
making them a viable therapeutic tool.
Author(S) Details
Kumari Rekha
Department of Zoology, Tmbu, Bhagalpur, Bihar, India.
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