Energy-Saving Pre-Gelatinization of Arthocarpus altilis Fruits Starch and Evaluation as Disintegrant in Oral Paracetamol Tablets | Chapter 7 | Current Aspects in Pharmaceutical Research and Development Vol. 6

 Natural polymers have been modified to give them desirable qualities, making them acceptable for use as medicinal additions. The goal of this project was to use acetone to make pre-gelatinized breadfruit starch, which would save drying time and energy consumption. In paracetamol oral compacts, the modified starch was tested as a disintegrant. The way disintegrants are incorporated has been shown to alter their performance, as well as the quality of the tablet and its release profile. To shorten drying time, starch from unripe mature bread fruit was pre-gelatinized and precipitated with acetone. Micromeritics, compatibility studies with test drugs utilising Fourier Transform Infrared (FT-IR), and water interaction features of native and pre-gelatinized starches were investigated (viscosity, swelling power and hydration capacity). Wet granulated paracetamol granules were crushed using starches as a disintegrant intragranularly, extragranularly, and a combination of both approaches. Studies on disintegration and dissolution have been completed. The native starch was not chemically altered by pre-gelatinization, and their pH was within pharmaceutical tolerances. The P2 and P3 (tablet batches containing pre-gelatinized starches) had a higher disintegration efficiency ratio (DER) than corn starch. In addition, the dissolution kinetics of the breadfruit starches followed the Hixson Crowel's model, but the Higuchi kinetic model better described the dissolution kinetics of reference maize starch. Breadfruit starch is palatable, and its pre-gelatinized form compares favourably to maize starch BP in terms of disintegrant characteristics. As a pharmacological excipient, it could be a viable option.

Author(S) Details

T. O. Uwah
Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria.

D. E. Effiong
Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria.

E. I. Akpabio
Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria.

G. Jacob
Pharmaceutics Unit, Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria.

I. Awa
Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria.

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