Using an aqueous extract of horse gramme, green chemistry was employed to generate nano-range sized titanium and zinc compounds from their macro-sizes (Macrotyloma uniflorum). Through natural biological processes, green technology allows metal ions to be transformed into metal nanoparticles. The nanoparticles of biosynthesized metal nanoparticles were characterised using ultraviolet-visible (UV-vis) and Fourier-transform infrared (FTIR) spectrophotometers. The reduced nanoparticles of Ti and Zn metals were studied using transmission electron microscopy (TEM). In vitro features such as the effects of nano complex antimicrobials on Mycobacterium tuberculosis (MTB) H37RV strain were determined using micro dilution. Patients with multidrug-resistant tuberculosis (MDR-TB) had MTB strains that were resistant to first-line treatments. Antituberculosis activity was demonstrated in newly manufactured nano-complexes. In comparison to zinc nano complexes, titanium nano complexes had the highest minimum inhibitory concentration (MIC). In a cytotoxic research, both Ti and Zn nano complexes had an IC50 of 1000 g/mL, indicating that they were non-toxic when compared to isoniazid.
Author(S) Details
Savita Belwal
Department of Chemistry, Anurag Group of Institutions, Venkatapur, Ghatkesar, Hyderabad-500038, India.
Sujana Kariveda
Department of Chemistry, Anurag Group of Institutions, Venkatapur, Ghatkesar, Hyderabad-500038, India.
Saritha Ramagiri
Department of Chemistry, Anurag Group of Institutions, Venkatapur, Ghatkesar, Hyderabad-500038, India.
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