Granulomatous Dermatitis and Systemic Disease: An Association to Consider | Chapter 10 | Highlights on Medicine and Medical Research Vol. 8

 Granuloma annulare and interstitial granulomatous dermatitis are two types of granulomatous dermatitis with different clinical manifestations. Granuloma annulare has been linked to diabetes, metabolic syndrome, chronic infections, and cancer, according to two Japanese studies, which identified rare cases of interstitial-type Granuloma annulare in the context of Sjogren syndrome. Rheumatoid arthritis, systemic lupus erythematosus, and autoantibodies have all been linked to interstitial granulomatous dermatitis. We present the results of a case series of six patients with granuloma annulare or interstitial granulomatous dermatitis, half of whom had Sjogren syndrome. Though they were all ANA-positive, the majority of them had arthralgia. In certain cases, the histology of granuloma annulare was interstitial, posing difficulties in distinguishing it from interstitial granulomatous dermatitis. The clinical and histological similarities between granuloma annulare and interstitial granulomatous dermatitis can be clarified by considering them as part of a larger disease continuum that includes other types of reactive granulomatous dermatitis. These symptoms should be taken as a warning sign of immune disorders or other immunological dyscrasias, for which patients should be screened. In Caucasians, Sjogren syndrome may be linked to granuloma annulare.

Author (s) Details

Alberto Corrà
Dermatology Unit, Department of Health Sciences, University of Florence, Florence, Italy.

Lavinia Quintarelli
Dermatology Unit, Department of Health Sciences, University of Florence, Florence, Italy.

Alice Verdelli
Division of Pathological Anatomy, Department of Surgical and Translational Medicine, University of Florence, Florence, Italy.

Francesca Portelli
Division of Pathological Anatomy, Department of Surgical and Translational Medicine, University of Florence, Florence, Italy.

Daniela Massi
Division of Pathological Anatomy, Department of Surgical and Translational Medicine, University of Florence, Florence, Italy.

Marzia Caproni
Dermatology Unit, Department of Health Sciences, University of Florence, Florence, Italy.

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