Metallothioneins and Their Influence on Bone Metabolism in Patients with Down Syndrome: Application to Dental Implants and Periodontitis | Chapter 11 | Current Progress in Medicine and Medical Research Vol. 6

 In this deoxyribonucleic acid validation study, we destined to verify the results of our first deoxyribonucleic acid expression analysis. Metallothionein’s (MTs) are the lower microscopic weight (6-7 kDa) proteins that are raise to be present in principal part organism types varying from prokaryotes to eukaryotes species. MT are the metal detecting proteins that can diminish the effect caused apiece excess alloy ions. The study was descriptive and practical, and the only invasive procedures acted on patients were the group of a small amount of ancestry and a dental examination.  We acted retrotranscription (RT-qPCR) of 11 RNA-to-cDNA samples using the SuperScript™ VILO™ kit (50; remark 1176605) from Thermo Fisher. We conducted the study utilizing the real-period PCR technique on the q-PCR ViiA 7 floor from Thermo Fisher. We chose the format of the Taqman Array Plate 16 Plus (citation 4413261) from Thermo Fisher, which shelters 12 genes plus four controls (GAPDH, 18S, ACTB, and HPRT1). We conducted the study of the plates using the Thermo Fisher Cloud Web Software. The results of changed MT expression that were first written came from the comparison middle from two points Down’s Syndrome patients accompanying periodontal disease and insert failure (PD+RI+) following in position or time two years of progression against Down’s syndrome sufferers without periodontal affliction and with a beneficial progression of their implants (PD-RI-). The results obtained through deoxyribonucleic acid validation study show that in PD+RI+ patients, the genes encrypting the isoforms MT1F (FD 0.3; p = 0.039), MT1X (FD 338; p = 0.0078), MT1E (FD 307; p = 0.0358), and MT2A (FD 252; p = 0.0428) continue to show downregulation, inasmuch as MT1B (FD 2.75; p = 0.580), MT1H (FD 281; p = 0.152), MT1L (FD 354; p = 0.0965), and MT1G (FD 336; p = 0.0749) no longer show statistically significant results. According to our results, metallotein absorption is related to cartilage metabolism disorders that influence the course of periodontitis and the deficiency of dental implants in subjects with Down syndrome.

Author(s) Details:

Maria Baus-Dominguez,
Department of Dentistry, Faculty of Dentistry, University of Seville, Seville, Spain.

Raquel Gomez-Diaz,
Institute of Biomedicine of Seville, Seville, Spain.

Jose-Luis Gutierrez-Perez,
Oral Surgery Department, Faculty of Dentistry, Oral and Maxillofacial Unit, Virgen del Rocio Hospital, University of Seville, Seville, Spain.

Daniel Torres-Lagares,
Department of Dentistry, Faculty of Dentistry, University of Seville, Seville, Spain.

Guillermo Machuca-Portillo,
Department of Dentistry, Faculty of Dentistry, University of Seville, Seville, Spain.

Maria-Angeles Serrera-Figallo,
Department of Dentistry, Faculty of Dentistry, University of Seville, Seville, Spain.

Please see the link here: https://stm.bookpi.org/CPMMR-V6/article/view/11483

Granulomatous Dermatitis and Systemic Disease: An Association to Consider | Chapter 10 | Highlights on Medicine and Medical Research Vol. 8

 Granuloma annulare and interstitial granulomatous dermatitis are two types of granulomatous dermatitis with different clinical manifestations. Granuloma annulare has been linked to diabetes, metabolic syndrome, chronic infections, and cancer, according to two Japanese studies, which identified rare cases of interstitial-type Granuloma annulare in the context of Sjogren syndrome. Rheumatoid arthritis, systemic lupus erythematosus, and autoantibodies have all been linked to interstitial granulomatous dermatitis. We present the results of a case series of six patients with granuloma annulare or interstitial granulomatous dermatitis, half of whom had Sjogren syndrome. Though they were all ANA-positive, the majority of them had arthralgia. In certain cases, the histology of granuloma annulare was interstitial, posing difficulties in distinguishing it from interstitial granulomatous dermatitis. The clinical and histological similarities between granuloma annulare and interstitial granulomatous dermatitis can be clarified by considering them as part of a larger disease continuum that includes other types of reactive granulomatous dermatitis. These symptoms should be taken as a warning sign of immune disorders or other immunological dyscrasias, for which patients should be screened. In Caucasians, Sjogren syndrome may be linked to granuloma annulare.

Author (s) Details

Alberto Corrà
Dermatology Unit, Department of Health Sciences, University of Florence, Florence, Italy.

Lavinia Quintarelli
Dermatology Unit, Department of Health Sciences, University of Florence, Florence, Italy.

Alice Verdelli
Division of Pathological Anatomy, Department of Surgical and Translational Medicine, University of Florence, Florence, Italy.

Francesca Portelli
Division of Pathological Anatomy, Department of Surgical and Translational Medicine, University of Florence, Florence, Italy.

Daniela Massi
Division of Pathological Anatomy, Department of Surgical and Translational Medicine, University of Florence, Florence, Italy.

Marzia Caproni
Dermatology Unit, Department of Health Sciences, University of Florence, Florence, Italy.

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