Background: Over a 5- to 9-year period (mean, 7.20.2), we
found that glimepiride was more effective than metformin in delaying the
progression from pre-diabetes to type 2 diabetes in non-obese subjects.
Metformin was the first-line treatment for newly diagnosed diabetics who were
overweight. Furthermore, neither group experienced any deaths or adverse
cardiovascular conditions, which could be due to beneficial improvements in
lipids and cardiovascular surrogate markers. The impact of interventions on
lipids and cardiovascular surrogate markers, on the other hand, was not
documented.
Prior to intervention, cardiovascular risk factors such as lipid fractions,
such as serum Total cholesterol (TC), Triglyceride (TG), Low Density
Lipoprotein Cholesterol (LDLC), High Density Lipoprotein Cholesterol (HDLC),
and other markers, such as homocysteine (HomC), highly sensitive C-Reactive
Protein (CRP), Fibrinogen (FIBR), and Plasminogen Activator Inhibitor1 (PAI1).
Subjects and Methods: The sample included 18 non-obese subjects, 10 men and 8
women between the ages of 27 and 78, and 20 obese subjects, 10 men and 10 women
between the ages of 32 and 81, who had pre-diabetes (fasting plasma glucose of
100 to 125 mg/dl and/or HbA1c of 5.7 to 6.4 percent). The research lasted 5 to
9 years (mean: 7.20.2). Glimepiride was given to non-obese subjects, while
metformin was given to obese subjects. At each visit during the study, subjects
were counselled on lifestyle intervention (appropriate diet and
exercise).Individual lipids and CV markers were compared at the start of the
study, six months later, and at the end of the study for each group, as well as
between groups for baseline and end-of-study levels.
Results: In the glimepiride group, significant improvements in all parameters
occurred after treatment (Post Rx) at 6 months and were sustained until the end
of the study. HbA1C ( percent ): 6.2 0.2, 5.5 0.1*, 5.7 0.1*; TC (mg/dl): 212
15, 174 13*, 178 14*; TG (mg/dl): 202 32, 162 28*, 178 14*; LD HDLC was not
affected in any way. Obese people who were given metformin experienced similar
improvements. There were no major differences between the two groups at the
start, 6 months, or end of the research.
Conclusion:
Glimepiride is equally efficient in enhancing lipid profiles and cardiovascular
surrogate markers in nonobese subjects with Pre diabetes as metformin is in
obese subjects, explaining similar cardiovascular results in both classes.
Author (s) Details
Reshma Esmail
Mount Saint Mary College,
Los Angeles, California, USA.
Udaya Manohar Kabadi
University of Iowa, Iowa City, Iowa, USA and Des Moines University, Des
Moines, Iowa, USA.
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