The oxygen balance of patients admitted to the emergency room or intensive care units (ICUs) must be monitored in real time. The number of monitoring devices that provide real-time data on tissue oxygen homeostasis is currently very small. The role of mitochondrial dysfunction in a variety of pathological conditions, including stroke, sepsis, and heart failure, necessitates real-time monitoring of this intracellular organelle. To prevent the most important organs in the body (brain and heart) from deteriorating, we propose monitoring a less vital organ, such as the urethral wall, which acts as an early warning signal for the loss of body oxygen balance. The use of a multiparametric monitoring system (CritiView) connected to the patient's urethral wall through a 3-way Foley catheter to measure four parameters representing tissue oxygen balance in real time is described in this study. Surface fluorometry/reflectometry is used to calculate mitochondrial NADH. Also assessed are tissue microcirculatory blood flow, tissue reflectance, and haemoglobin oxygenation. The four calculated parameters could be combined with systemic hemodynamic parameters to generate a new Tissue Metabolic Score in real time (TMS). Small animal models (rats and gerbils) were used to monitor the device in vitro and in vivo when they were subjected to changes in local or systemic oxygen balance. Patients undergoing vascular or open heart surgery were also subjected to preliminary clinical trials. The monitoring of patients began immediately after a 3-way Foley catheter (urine collection) was inserted and ended when the patient was released from the operating room. The findings indicate that tracking the urethral wall oxygen balance offers real-time data that is linked to the status of the surgical procedure. We discovered that the TMS of the urethral wall could serve as an early warning signal for potential damage to the body's most vital organs.
Author (s) Details
Avraham Mayevsky
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290092, Israel.
Michael Tolmasov
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290092, Israel.
Hofit Kutai-Asis
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290092, Israel.
Mira Mandelbaum-Livnat
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290092, Israel.
View Book :- https://stm.bookpi.org/HMMR-V5/article/view/690
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