Research on Scintimetric Characterization of Skeletal Hotspots by Dr. V. Siva’s Retention Ratio in a Diagnostic Referral Center | Chapter 7 | Highlights on Medicine and Medical Research Vol. 5

 The aim of this study is to show that Scintimetric Characterization of Skeletal Hot Spots seen in Bone Scans performed in this referral centre between 2016 and 2017 will help distinguish between metastatic and non-metastatic lesions.

The study group consists of 59 patients who were referred to our centre for metastatic evaluation and non-specific bone complaints. Using a GE Millenium Gamma Camera, a whole-body bone scan was performed 3 hours after an intravenous injection of 15 to 25 mCi of Tc99m MDP. Both those who had focal hot spots in their scans and who agreed willingly with the permission of the referring physician had their whole body bone scan repeated after 24 hours. The area ratio count protocol was used to measure the counts in the focal hot spots at 3 and 24 hour bone scan images. In the focal hotspots, the retention ratio was determined by dividing the 3-hour counts by the 24-hour counts. The metastatic and non-metastatic groups' values were tallied and analysed.

Results: Of the 59 scans in our collection, 35 (59%) were negative and showed no focal shifts. 24 of the 59 scans (41% ) revealed focal shifts in the form of hot spots. Out of the 69 hot spots examined, 31 (45%) had a value of 13.07 1.02, suggesting that the lesions were metastatic, and 38 (55%) had a value of 6.07 0.62, indicating that the lesions were benign. As a result, the metastatic group's mean value was nearly twice that of the benign group. The statistical analysis indicated that the two groups were significantly different.

Conclusion: In the tertiary referral diagnostic centre, the Scintimetric characterization of the focal hot spots by Dr. V. Siva's retention ratio effectively provides useful means to distinguish between metastatic and non-metastatic lesions.

Author (s) Details

V. Sivasubramaniyan
Department of Nuclear Medicine & Molecular Imaging, Sri Aurobindo Institute of Medical Sciences, Sri Aurobindo University, Indore, Madhyapradesh, India and Department of Physics, Sri Sathya Sai Institute of Higher Learning, Vidyagiri, Prasanthinilayam, Andhra Pradesh, India.

K. Venkataramaniah
Department of Physics, Sri Sathya Sai Institute of Higher Learning, Vidyagiri, Prasanthinilayam, Andhra Pradesh, India.

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