Dilutions of Apis mellifera Improve Metabolic Abnormalities Induced by Antiretroviral Therapy in Mice | Chapter 3 | Highlights on Medicine and Medical Research Vol. 6

 Background: Highly Active Antiretroviral Therapy (HAART) is linked to a lower risk of death and a lower risk of AIDS progression. Complications from long-term HIV infection and treatment, on the other hand, have become increasingly important. Hepatic and nephrotoxic effects of HAART are among the risks. Honeybee (Apis mellifera) venom has been shown to have anticancer, antimicrobial, immunomodulatory, and vasoconstrictor properties in studies. The current research examines the impact of Apis mellifera dilutions on metabolic changes in mice receiving antiretroviral therapy (HAART).

Material and Methods: There were ten animals in each experimental group: (I) animals given HAART diluted in 1.2 mL water gavage/day, (II) animals given HAART diluted in 1.2 mL water gavage/day + Apis mellifera diluted 1x1012 in water 1.0 mL once daily added to the drinking water (1:10 mL) available ad libitum, (III) animals given HAART diluted in 1.2 mL water gavage/day + Apis mell The study groups were given 15 days of treatment. Before and after treatment, clinical evaluations (body weight, water intake and ration, excretion products, behaviour) were conducted, and serum cholesterol, triglycerides, hepatic enzymes (AST, ALT), and creatinine were measured using unique methods. Student's t test was used to analyse the data in Graph Pad Prism.

When compared to animals treated with antiretroviral therapy, animals treated with HAART and Apis mellifera diluted (II and III) had higher body weight gain, lower levels of triglycerides (20%), cholesterol (20%), and creatinine (50%).

Conclusion: Our findings show that Apis mellifica extract, when used in a diluted form, has antiretroviral therapy-friendly effects in animals. The levels of cholesterol, triglycerides, liver enzymes, and renal profile have all improved.

When compared to the HAART sample, Apis mellifera diluted 1x1012 and 1x1060 had a major impact on creatinine levels and indicated a potential effect on kidney injury.

Author (s) Details

M. L. Recco
Department of Basic Health Sciences, State University of Maringá, Maringá, PR, Brazil.

L. B. Bornia
Department of Basic Health Sciences, State University of Maringá, Maringá, PR, Brazil.

T. Sakurada Jr
Department of Basic Health Sciences, State University of Maringá, Maringá, PR, Brazil.

T. Sakurada Jr
Department of Basic Health Sciences, State University of Maringá, Maringá, PR, Brazil.

A. R. T. Pupulin
Department of Basic Health Sciences, State University of Maringá, Maringá, PR, Brazil.

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