Acute kidney failure is a significant side effect of a variety of inflammatory diseases of the abdominal and thoracic cavities, extreme injuries and burns, eclampsia and sepsis, and a variety of infectious diseases. Considering the wide range of etiologies, there is a common pathogenesis function that is dependent on endoxemia and the accumulation of a number of toxic products that cause perivascular edoema, decreased renal blood flow, glomerular filtration, tubular necrosis, and oligoanuria, as well as disruptions in the vessels endothelium permeability. The most popular treatment strategy is to use kidney replacement therapy, which consists primarily of various hemofiltration methods. However, not all hazardous substances are eliminated, and the mortality rate remains high. When hemosorption and plasmapheresis are used in a complex of therapeutic steps, the outcomes are more beneficial and stable, with a substantial reduction in mortality.
Author (s) DetailsV. A. Voinov
I.P. Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia.
M. G. Kovalev
I.P. Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia.
K. S. Karchevsky
I.P. Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia.
O. V. Isaulov
I.P. Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia.
Y. V. Voinova
I.P. Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia.
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