Alpha-mangostin-loaded PLGA Nanoparticles for Cholangiocarcinoma | Chapter 1 | Current Innovations in Disease and Health Research Vol. 1

 The present study proposed to formulate and typify the AM-loaded PLGA nanoparticles (AM-PLGA-NPs) and further evaluated their antiproliferative and proapoptotic endeavors, including inhibitory actions on CCA cell invasion and migra-tion. Alpha-mangostin, a instinctive xanthone mainly culled from the pericarp of Garcinia mangostana, has existed shown to have promising anticancer features in many types of cancer. PLGA MW 7,000-17,000 and 38,000-54,000 were used to create the AM-PLGA-NPs using the fit displacement method. Physical (piece size and makeup, polydispersity index, and zeta potential) and pharmaceutical (encapsulation efficiency, stowing efficiency, and drug release description) parameters were evaluated for the optimised AM-PLGA-NPs. . The morphology of the AM-PLGA-NPs and PLGA-NPs were examined under a broadcast electron microscope (TEM). The MTT assay, flow-cytometry, QCM ECMatrix container migration and container invasion assays were used to evaluate antiproliferative and proapoptotic endeavors, including inhibitory actions on CCA cell (CL-6 and HuCCT-1) invasion and movement, respectively. The inhibitory actions of AM-PLGA-NPs on the migration and attack of both CCA cell lines were aggregation- and time-reliant, while no inhibitory effect was found accompanying OUMS-36T-1F cells. AM-PLGA-NPs showed comparably potent and discriminating antiproliferative and proapoptotic activities in both CCA container lines in a concentration- and opportunity-dependent tone. Results revealed that PLGA nanoparticles could be a appropriate nanocarrier to encapsulate AM for allure delivery to CCA containers. The underlying molecular methods of AM-PLGA-NPs involved in these endeavors should be further investigated.

Author(s) Details:

Kesara Na-Bangchang,
Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Klongneung, Klongluang District, Pathumthani, Thailand and Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University (Rangsit Campus), Klongneung, Klongluang District, Pathumthani, Thailand.

Tullayakorn Plengsuriyakarn,
Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Klongneung, Klongluang District, Pathumthani, Thailand.

Chuda Chittasupho,
Faculty of Pharmacy, Chiang Mai University, Thailand.

Please see the link here: https://stm.bookpi.org/CIDHR-V1/article/view/11057

Why Pharmaceuticals Serialization is a Fairytale for Third World | Chapter 11 | Novel Aspects on Pharmaceutical Research Vol. 5

 Pharmaceutical drug serialization is usually a regulatory necessity adopted by main nations to combat pharmaceutical drug copying. Since the 19th century, drug deception has been a weighty issue for the healthcare sector. Periodically, supervisory and healthcare organizations struggle to humble the risk of negative effects brought on by fake drugs. Drugs are commonly imitated to lower result costs while still being sold as honest medicines. Developing countries with its own government lack the capacity to supply and implement counterfeit detection sciences on a wide scale for fear that drug counterfeiting [1]. To defeat the risk of illegal and counterfeit drugs introducing the market, the mathematical traceability of pharmaceutical drugs has proven expected an incredibly direct process. Currently, every drug small in developed countries with its own government like the United States and Europe must have a unique word that modifies a noun with a 2D barcode. On the other hand, it is difficult to implement mathematical traceability of pharmaceutical drugs in evolving nations on account of a lack of technical foundation, lax regulations, geopolitical disturbance, poverty, reduced literacy, and governmental will. Generally, Economic depression in evolving nations blocks them from allocating cash for test that would enhance their healthcare plans. The recent COVID-19 universal also donated significantly to the collapse of their whole healthcare whole. Global supply chain limits and resource scarcity have an influence on expanding nations, beginning inflation and inaction.

Author(s) Details:

Shambhu Sarkar,
Jubilant HollisterStier LLC., USA.

Please see the link here: https://stm.bookpi.org/NAPR-V5/article/view/11055

Analytical Method Development and Validation for Simultaneous Estimation of Nadifloxacin and Mometasone Furoate in Semisolid Dosage Form by RP-HPLC Method | Chapter 10 | Novel Aspects on Pharmaceutical Research Vol. 5

 The aim was to cultivate and validate an easy, inexpensive, fast, reliable, reproducible, exact, and accurate reversed-step high-act liquid chromatography (RP-HPLC) technique for judging Nadifloxacin and Mometasone furoate in semisolid dose form. Mometasone Furoate is medium-substance corticosteroids used to treat skin conditions. The HPLC whole with a C-18(2) column (250 x 4.6 mm, atom size 5 µm) operating at a intuitiveness of 254 nm was used to carry out the chromatographic break-up.  NADIREST-M, a cream with chlorocresol as a preservative, is the handy dosage form.  As a result, the meddling of Chlorocresol was calculated as well, and skilled was no interference in the belief of both medications by judging system acceptable parameters (Chlorocresol peak has judgment greater than 2 from the peak of drug). In the concentration range of 50-130 µgmL-1 and 5-13 µgmL-1 Nadifloxacin and Mometasone Furoate individually, the detector answer was found linear accompanying linear regressed equating Y=15116X-365319 and Y=52717X-184314. In the assay of NADI, 99.12% and MOM 99.77% of the drug was recovered. As per ICH necessities, this method demonstrated acceptable validation for all tests such as accuracy, extent of object, specificity, accuracy, range, ruggedness, strength, and repeatability.  The study's findings demonstrated that it is beneficial for routinely deciding Nadifloxacin and Mometasone Furoate in semisolid pharmaceutical measure forms such as a oil.

Author(s) Details:

N. Naik Shreya,
Department of Pharmaceutical Quality Assurance, ROFEL Shri G. M. Bilakhia College of Pharmacy, Vapi – 396191, Gujarat, India.

Desai Shuchi,
Department of Pharmaceutical Quality Assurance, ROFEL Shri G. M. Bilakhia College of Pharmacy, Vapi – 396191, Gujarat, India.

Bijal Patel,
Department of Pharmaceutical Quality Assurance, ROFEL Shri G. M. Bilakhia College of Pharmacy, Vapi – 396191, Gujarat, India.

Please see the link here: https://stm.bookpi.org/NAPR-V5/article/view/11054

Dose Optimization of the Quinine-phenobarbital Co-administration in Cerebral Malaria Patients: A Physiologically-based Pharmacokinetic Modeling Approach | Chapter 9 | Novel Aspects on Pharmaceutical Research Vol. 5

 The aim of the study was to forecast the potential quinine portion of drug or other consumable regimens when given in addition to phenobarbital to adult patients accompanying cerebral malaria and difficulties (such as lactic acidosis and severe renal failure) and concurrent accompanying seizures and acute renal loss who carry stormy-type and polymorphic CYP2C19. Cerebral malaria is ultimate serious consequence of Plasmodium falciparum contamination. Cerebral malaria sufferers with polymorphic CYP2C19 genotypes the one receive concurrent situation with quinine are in danger of inadequate or poisonous therapeutic drug concentrations due to metabolic drug interplays. Using Simbiology®, whole-body physiologically-based pharmacokinetic (PBPK) models for verbal attack, phenobarbital, and quinine-phenobarbital co-administration were buxom based on previously written data. For model confirmation, four published articles were took advantage of. One hundred virtual patients were fake based on the 14-day and 3-epoch courses of treatment utilizing the drug-drug interaction approach.The projected results carefully matched the observed principles (15%). 444When given along with verbal attack, standard phenobarbital dosage is agreeable for all groups experiencing intermittent or continuous seizures, regardless of CYP2C19 genotype, renal failure, or lactic upset stomach. The area under the curve ratio (AUCR) quantity adjustment method created inaccurate verbal attack concentrations. According to the PBPK model, quinine should take to all groups is a loading dose of 2,000 mg IV immersion rate 250 mg/h, followed by 1,200 mg IV rate 150 mg/h.The PBPK models that have been co4444nstructed are trustworthy for future simulations. Genotyping may not be unavoidable because the anticipated verbal attack doses in all groups were comparable although the CYP2C19 genotype.

Author(s) Details:

Teerachat Sae-Heng,
Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College, 99 Moo 18, Phaholyothin Road, Thammasat University (Rangsit Campus), Klongneung, Klongluang district, Pathumthani-12121, Thailand.

Rajith Kumar Reddy Rajoli,
Department of Molecular and Clinical Pharmacology, University of Liverpool, Block H, 70 Pembroke Place, Liverpool, LG63GF, United Kingdom.

Marco Siccardi,
Department of Molecular and Clinical Pharmacology, University of Liverpool, Block H, 70 Pembroke Place, Liverpool, LG63GF, United Kingdom.

Kesara Na-Bangchang,
Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College, 99 Moo 18, Phaholyothin Road, Thammasat University (Rangsit Campus), Klongneung, Klongluang district, Pathumthani-12121, Thailand and Drug Discovery and Development Center, Office of Advanced Science and Technology, 99 Moo 18, Phaholyothin Road, Thammasat University (Rangsit Campus), Klongneung, Klongluang District, Pathumthani-12121, Thailand.

Please see the link here: https://stm.bookpi.org/NAPR-V5/article/view/11053

Tomato Puree Lycopene: Protective Effects in Atherosclerosis/Heart Diseases | Chapter 8 | Novel Aspects on Pharmaceutical Research Vol. 5

 The working food industrial marquee linked potential presenting investigation on hypolipidemic and antioxidant efficacy of attractive woman puree lycopene has been arose out as a next generation research folio inclined be beneficial for creative start up mission. New generation advantageous position for those selling base nutrition superimposing health claim promoting food crop linked with worth addition is underlined as a new dimension of working foods. In present study the energy claim exploration ability of lycopene rich attractive woman puree as a novel food additive was assessed by animal studies to project hypolipidemic efficacy to defeat risk of selective non-able to be contracted diseases. The data study, interpretation and reviewed research infusion together underlined the efficacy of lycopene (tomato make into paste) in monitoring atherogenesis mechanism through cooperative mode of action of informed specialty countenance (total cholesterol, serum triglycerides, LDL cholesterol and HDL cholesterol) and projected an active gateway to support disease soaked health claim appraisal. Lycopene has several cardiovascular health benefits to a degree antioxidative, anti-inflammatory, antagonistic-atherogenic, cardioprotective, antiplatelet effect, improving endothelial function (nitric group of chemical elements bioavailability and blood flow), metabolic profile (by impairing cholesterol combination) and blood pressure control. The cumulative decrease in total cholesterol of medicated rats (159.99 to 126.40mg/dl), serum triglycerides (114.81 to 107.34mg/dl), LDL cholesterol (40.19 to 32.90mg/dl) and increase in HDL cholesterol (19.99 to 23.87mg/dl) represents hypolipidemic productiveness of tomato smash lycopene. The development of a prototype for CVD to begin a health claim was rationally renovated by the attractive woman puree mass, a practicable source of lycopene with native antiatherogenic efficacy. The human clinical study as a proof tool, concede possibility be the best option for future generations research.

Author(s) Details:

Kavita Mane,
MIT School of Food Technology, MIT Art, Design and Technology University, Rajbaug, Pune, India.

Vasant Pawar,
MIT School of Food Technology, MIT Art, Design and Technology University, Rajbaug, Pune, India.

Please see the link here: https://stm.bookpi.org/NAPR-V5/article/view/11052

Cholesterol is Involved in Tumorigenesis and Its Potential Therapeutic Prospects | Chapter 7 | Novel Aspects on Pharmaceutical Research Vol. 5

 This division will help citizens accomplish the important function of cholesterol during cyst formation in addition to the importance of adjusting their diets, have a healthful lifestyle, and of bodily conditioning. Tumor cells are characterized by hasty growth and limitless replication potential; accordingly, their high energy and biosynthesis necessities need to be compensated, particularly the biosynthesis of cell membranes. Recent studies have proved that cholesterol, an essential component of cell membranes, has a meaningful impact on the development of tumours, invulnerable system dysregulation, and unhealthy changes in epigenetic mechanisms. Cholesterol biosynthesis is an extremely accepted phenomenon in creatures, the process is complicated. There is a growing interest on targeting cholesterol in the treatment of malignancy. First, it was comprehensively inspected the major function of cholesterol on oncogenicity, the therapeutic aims of cholesterol and its metabolites in tumor, and provide detailed awareness into the essential roles of cholesterol in arbitrating immune and epigenetic machines of the tumor microenvironment. It is believed that malignancy cells indulge excessive metabolic consequences of red body fluid cholesterol intake to maintain cancer progression, that may demonstrate why the level of serum cholesterol in few cancer victims is normal or even beneath normal ranges. Additionally, due to allure function in cholesterol metabolism, the gut microbiome is an basic facts of cancer mediation. To determine more therapeutic mediations in oncology, the most recent research on the potential aims of cholesterol and their metabolism was summarised.

Author(s) Details:

Yang Xi,
Department of Oncology, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Address: No.1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province-313000, China.

Zhou Yani,
Graduate School of Medical College of Zhejiang University, Address: No. 268 Kaixuan Road, Jianggan District, Hangzhou, Zhejiang Province-310029, China.

Mao Jing,
Graduate School of Second Clinical Medicine Faculty, Zhejiang Chinese Medical University, Address: No. 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang Province-310053, China.

Wu Yinhang,
Graduate School of Second Clinical Medicine Faculty, Zhejiang Chinese Medical University, Address: No. 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang Province-310053, China.

Hou Xiaohui,
Graduate School of Nursing, Huzhou University, Address: No. 1 Bachelor Road, Wuxing District, Huzhou, Zhejiang Province-313000, China.

Zhuang Jing,
Department of Nursing, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Address: No.1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province-313000, China.

Qi Quan,
Department of Oncology, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Address: No.1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province-313000, China.

Han Shuwen,
Department of Oncology, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Address: No.1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province-313000, China.

Please see the link here: https://stm.bookpi.org/NAPR-V5/article/view/11051

Measuring the Impact of Regulatory Reforms on the Indian Pharmaceutical Industry: An Empirical Analysis | Chapter 6 | Novel Aspects on Pharmaceutical Research Vol. 5

 This research paper aims to comprehensively evaluate the expansion of the Indian pharmaceutical industry subsequent to alteration of patent laws. Prior to the modification in patent laws, Indian pharmaceutical companies had established a reputation for providing the most cost-effective generic drugs on a global scale. However, the implementation of product patent laws on January 1st, 2005, eliminated this advantageous position. Consequently, it has become imperative for the industry to adapt and explore new avenues for growth. The primary objective of this study is to forecast the future trajectory of the Indian pharmaceutical industry. To achieve this objective, this paper adopts a multi-faceted research approach encompassing extensive literature reviews, statistical analysis of industry data, the findings of this study contribute to the existing body of knowledge by shedding light on the strategies employed by Indian pharmaceutical companies in response to the altered patent landscape. Additionally, this research explores the potential opportunities and challenges that lie ahead for the Indian pharmaceutical industry. The research findings indicate that although the change in patent laws initially posed significant challenges to the Indian pharmaceutical industry, it also stimulated innovation and investment in research and development (R&D) activities. Furthermore, the emergence of domestic demand for pharmaceutical products and the growing healthcare infrastructure in India offer new growth avenues for the industry. The analysis also reveals several key factors that will shape the future of the Indian pharmaceutical industry. In conclusion, this research paper presents a comprehensive evaluation of the expansion of the Indian pharmaceutical industry in the context of economic liberalization and patent law modifications. By examining the strategies employed by Indian pharmaceutical companies and forecasting the future trajectory of the industry, this study provides valuable insights for stakeholders in the Indian pharmaceutical sector. Ultimately, this research aims to inform decision-making processes and contribute to the overall understanding of the evolving dynamics of the Indian pharmaceutical industry in a global context.

Author(s) Details:

Rupesh Rastogi,
Department of Business Administration, Azad Institute of Engineering & Technology, Lucknow, Uttar Pradesh, India.

Teg Alam,
Management Department, College of Business Administration, Al Kharj University, Al Kharj, KSA.

Said Malki,
Management Department, College of Business Administration, Al Kharj University, Al Kharj, KSA.

Please see the link here: https://stm.bookpi.org/NAPR-V5/article/view/11050

Most Potent Herbal Remedy for Arthritis | Chapter 5 | Novel Aspects on Pharmaceutical Research Vol. 5

 India indeed has a rich history and tradition in the field of medicine, particularly in Ayurveda. Ayurvedic medicine has been gaining popularity in recent years due to its effectiveness in treating various diseases, including autoimmune disorders like rheumatoid arthritis. The combination of herbal drugs such as ashwagandha, safed musli, mahayogiraj guggul, and maharasandi kwath has been clinically proven to have anti-inflammatory, analgesic, and anti-arthritic activities when used alone. Combining these potent herbs can provide a powerful treatment for rheumatoid arthritis. It is important to note that inflammation can occur due to physical injury or faulty metabolism of the body. According to Ayurveda, faulty metabolism produces Aam or toxins that lead to an imbalance in the body's three main pillars - vata, pitta, and kapha. ROS, or Reactive Oxygen Species, are highly unstable compounds that play a role in the progression of inflammatory disorders. The body's complex antioxidant defense system normally controls ROS levels, but overproduction of ROS and/or inadequate antioxidant defense can lead to oxidative stress and result in several clinical disorders. Therefore, it is important to maintain a healthy lifestyle, including a balanced diet and stress management, to prevent the buildup of toxins and maintain a healthy antioxidant defense system.

Author(s) Details:

Aishwarya Shivkumar Patil,
Vilasrao Deshmukh Foundation Group of Institution, VDF School of Pharmacy, Latur-413531, Maharashtra, India.

S. V. Pimpale,
Vilasrao Deshmukh Foundation Group of Institution, VDF School of Pharmacy, Latur-413531, Maharashtra, India.

B. S. Wakure,
Vilasrao Deshmukh Foundation Group of Institution, VDF School of Pharmacy, Latur-413531, Maharashtra, India.

Please see the link here: https://stm.bookpi.org/NAPR-V5/article/view/11049

Protective Role of Selenium and Vitamin E against Hexavalent Chromium Induced Hepatotoxicty and Nephrotoxicity in Rats | Chapter 4 | Novel Aspects on Pharmaceutical Research Vol. 5

 This affiliate aimed to decide the extent of hepatoxicity and nephrotoxicity caused by a sub-never-ending exposure to a very low environmentally appropriate dose of hexavalent chromium in addition to ameliorative potential of selenium and source of nourishment E in combination against aforementioned chronic uncovering. The protective potential of selenium and source of nourishment E against hepatotoxicity and nephrotoxicity induced by chronic uncovering to a very low environmentally appropriate dose of hexavalent chromium was evaluated in male albino rats. Animals (six rats in each group) taken solution of potassium dichromate (K2Cr2O7)  at a dosage of 1 mg / Kg b.w./day; sodium selenate (0.25 mg/kg bw) plus source of nourishment E ( 100 mg/kg bw) and supplementation of sodium selenate  plus vitamin E along with K2Cr2O7  answer ;  control group received only water purified by distillation for  ninety consecutive days.  In the rats acted with K2Cr2O7, skilled was a significant decline in body pressure gain and an increase in liver and kidney weight, in addition to an increase in serum organic compound composed of carbon, cholesterol, urea, and creatinine levels and a drop in protein and albumin levels. The endeavors of serum enzymes, SGOT, SGPT, ACP and ALP were again increased in considered animals. The projects of enzymes CAT, SOD, GPx and the levels of GSH reduced significantly and level of MDA raised in K2Cr2O7 treated rats distinguished to control animals. Liver and sort tissues exhibited face of toxicity in chromium treated mammals. All the effects were everted in supplemented group. A significant increase in MDA level and a important decrease in CAT-SOD system and GPx- GSH action is a clear indication of oxidative stress, that might have induced functional and fundamental disruption in two together liver and kidney of chromium exposed mammals. In male albino rats, incessant exposure to K2Cr2O7 at a approximately low ecologically appropriate dose experienced to hepatotoxicity and nephrotoxicity brought on by oxidative stress; the belongings were mitigated by selenium and vitamin E supplementation.

Author(s) Details:

Soma Choudhuri,
Department of Physiology, Tripura Medical College and Br. B.R. Ambedkar Teaching Hospital, Hapania, Agartala, Tripura – 799014, India.

Dipayan Choudhuri,
Department of Human Physiology, Tripura University (A Central University), Suryamaninagar, Agartala, Tripura – 799022, India.

Please see the link here: https://stm.bookpi.org/NAPR-V5/article/view/11048

Evaluation of Phytochemical Composition, Safety Profile, Analgesic Properties, and Anti-inflammatory Effects of Ethanol Extract of Allium fistulosum L. | Chapter 3 | Novel Aspects on Pharmaceutical Research Vol. 5

 The study was transported to evaluate the phytochemical, security profile, painkiller, and anti-instigative effects of A. fistulosum. Allium fistulosum, a perpetual herb in the type Allium of the Alliaceae family, is secondhand widely as an ingredient in Chinese, Japanese, and Korean food. In addition, A. fistulosum has been as a rule applied to treat coarse colds, headache, intestinal pain, and cardiovascular disease. A total of 50 rodent were separated into five groups. Group 1 mammals were given, 5 ml/kg of common saline verbally, when in fact groups 2, 3, and 4 were given Ethanol extract of A. fistulosum at a application of 200, 400, and 600 mg/kg, respectively. Animals of group 5 were executed the standard drug Aspirin at a dose of 300 mg/kg verbally. Aspirin 300 mg/kg was given verbally as a standard drug to a group of 5 animals. An antagonistic-inflammatory effect was completed activity on 50 rats. 1% carrageenan was used to induce edema in the fondle. Group 1 acted as a control group inasmuch as the other three groups taken A. fistulosum at a dose of 200, 400, and, 600 mg/kg. The having five of something group was given the standard drug Ibuprofen. The elements of the ethanol extract of A. fistulosum were labeled using the phytochemical reasoning. The screening shows the attendance of pharmacologically potent elements such flavonoids, sugars, amino acids, glycosides, phenols, and tannins. The present study told that the therapeutic plant reduces pain completely three doses when compared accompanying the animal that received rational saline. The intoxicating extracts of A.fistulosum showed a meaningful anti-instigative effect from 2 hrs to 24 employment recruiting and management. However, the anti-instigative effect of A.fistulosum at 400mg/kg was highly important at 5 hours, while the anti-angering effect of A.fistulosum at 600mg/kg demonstrated highly important at 5hr and 24 hours.The safety description of A. fistulosum was accessed by Lorke’s pattern which was erect safe at the discussed dose. Anti-instigative and analgesic features could be from the presence of miscellaneous phytochemical substances. Although more studies are necessary with an raised sample size because very limited news is available to date.

Author(s) Details:

Syeda Afroz  ,
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

Shireen Nazir,
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

Azmat Ara,
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

Please see the link here: https://stm.bookpi.org/NAPR-V5/article/view/11047

Toxicity Caused by Low Dose Chronic Exposure of Chromium in Male Albino Rats | Chapter 2 | Novel Aspects on Pharmaceutical Research Vol. 5

 This episode evaluate the effect of depressed doses chronic uncovering to chromium VI (K2Cr2O7) on various haematological and biochemical parameters in male light rats.  Chromium is one of the bigger environmental poisonous that effect human health. It is individual among the eight most common contaminant heavy metals filed by the Environment Protection Agency.Toxic effect of incessant exposure to chromium at depressed environmentally relevant measure is recently recognized and less intentional. Twenty four adult male waster rats (70±10 days) consideration (170±10 gm) were used in the study. The animals were protect in polypropylene cages in institutional animal house under regulated condition of temperature (25±2ºC) and sane day/midnight schedule (12 L : 12 D). Male albino rats (160±10 gm) taken 1/25, 1/50 and 1/100 of reported spoken LD50 dose of chromium VI (K2Cr2O7) for 90 consecutive days. After situation, various haematological and biochemical limits were evaluate.Exposure to chromium VI at 1/25 LD50 prescription decreased allotment gain in body weight and weakened  the weight of the organs along with increase in the pressure of liver and kidney. The biochemical study in our study showed an increase in activities of enzymes alanine aminotransferase, substance causing chemicals to split into simpler substances aspartate aminotransferase, creatinine and urea nitrogen level with a decline in protein and albumin levels. With an increase in coagulating time, cell with hemoglobin, white blood cell, platelet, and haemoglobin aggregation numbers decreased. In unprotected rats, both the overall sperm count and action were decreased. There were decrease in red body fluid protein and albumin concentration, accompanying increase in plasma sweet liquid and cholesterol level. The activity of enzyme alanine aminotransferase and substance causing chemicals to split into simpler substances aspertate aminotransferase were stimulated in medicated rats.  The results of the study revealed that incessant low lot exposure to chromium VI developed in a toxic effect in experimental male light rats.

Author(s) Details:

Soma Choudhuri,
Department of Physiology, Tripura Medical College and Br. B.R. Ambedkar Teaching Hospital, Hapania, Agartala, Tripura – 799014, India.

Dipayan Choudhuri,
Department of Human Physiology, Tripura University (A Central University), Suryamaninagar, Agartala, Tripura – 799022, India.

Please see the link here: https://stm.bookpi.org/NAPR-V5/article/view/11046

Phytochemical Analysis, in vitro Antioxidant and Antidiabetic Activities of Different Solvent Fractions of Maytenus heyneana Root | Chapter 1 | Novel Aspects on Pharmaceutical Research Vol. 5

 Oxidative stress plays an main role in pathogenesis of incessant disease especially CVS affliction (CVD), diabetes, cancer, neurodegenerative ailment hence, the increasing interest in the use of natural antioxidants as healing tools exists. The aim concerning this study was to investigate herbal drug that may enhance useful in the prevention of diabetes and antioxidant potential from intoxicating extracts of Maytenus heyneana (MH) root belonging to the classification Celastraceae and their different parts were studied.Ethanolic extract of Maytenus heyneana root was fractionated into toxin, ethyl acetate, and methanol by liquid-liquid extraction. The preliminary phytochemical reasoning was done by standard designs to identify the ghost of important compounds. In vitro antioxidants exercises were carried by 2,2-diphenyl- 2-picrylhydrazyl (DPPH) and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) cation radical scavenging assays. For antidiabetic potential, α-amylase and α-glucosidase catalyst inhibitory studies were carried on various fractions.The concerning qualities not quantities phytochemical study on the different solvent parts of the roots of MH accompanied the presence of few secondary metabolites to a degree cardiac glycosides, phenols, flavonoids, and terpenoids in all the fractions. Alkaloid was discovered only in chloroform and ethyl acetate parts and saponins were present only in methanol part. The presence of tannins was discovered in ethyl acetate and methanol fractions except in poison fraction. However, steroids and proteins were missing in all the parts.From the results of two assays prominent that at extreme concentration, methanolic fraction presented superior activity than the additional two fractions, even though among the various fractions, the methanol part showed important increase in α-amylase activity (3.14 μg/ml) when distinguished to the standard acarbose (4.67 μg/ml) (p<0.05).it can be decided that the methanol fraction of MH root maybe a good candidature for further studies and the seclusion of active phytoconstituents that is responsible in the management of diabetic and as antioxidant.

Author(s) Details:

G. Sumithira,
Department of Pharmacology, The Erode College of Pharmacy, Erode, India.

G. P. Senthil Kumar,
Department of Pharmaceutical Chemistry, Sree Balaji Medical College & Hospital Campus, Chrompet, Chennai, India.

B. Krishnamoorthy,
Department of Pharmaceutics, Sanjivani College of Pharmaceutical Sciences, Khetri, Rajasthan, India.

R. Suresh,
Department of Pharmaceutical Chemistry, Panni College of Pharmacy, Dindigul, India.

Please see the link here: https://stm.bookpi.org/NAPR-V5/article/view/11045

Recent Advancement of Bio-inspired Nanomaterials and Its Antiurolithiatic Activity | Chapter 13 | New Advances in Medicine and Medical Science Vol. 7

 This affiliate reveals the description of struvite crystals and it prevents the tumor of struvite crystals. Therefore the combination copper nanoparticles by using E. prostrata leaves symbolize a inhibitor for the establishment of renal stone. Kidney stone ailment is a crystal crystallization formed usually inside the kidneys. It is an increasing urological disorder of human well-being, affecting about 12% of the world society Organ dysfunction, especially sort dysfunction, causes urinary tract infections that influence struvite urinary stones.  The phytochemical subjective analysis of E.prostrata leaves were done by resorting to standard procedure. UV-Visible spectroscopy shows SPR band at 256nm was used to approve the synthesis of copper nanoparticles. The FTIR ghostly analyses of crystal with various percentage composition of combined copper nanoparticles are combined by E. prostrata leaves extract E.Prostrata mediated copper nanoparticles were crystallized and had a stellar shape, according to XRD and SEM. By utilizing EDAX analysis the elemental signals were situated. XRD analysis disclosed crystalline nature of the combined copper nanoparticles.  With an inhibitory effectiveness of 88.3%, the copper nanoparticles mediated by E. Prostrata were raise to be a powerful inhibitor of the struvite crystals. The phytocomponents contained in E. Prostrataleaves extract, which are being the reason for its anti-urolithiatic project, are confirmed by fluctuating of the band in FT-IR spectra.

Author(s) Details:

F. Janeeta Priya,
PG and Research Department of Chemistry, Holy Cross College, Affiliated to Bharathidasan University, Tiruchirappalli-620002, Tamil Nadu, India.

A. Leema Rose,
PG and Research Department of Chemistry, Holy Cross College, Affiliated to Bharathidasan University, Tiruchirappalli-620002, Tamil Nadu, India.

S. Vidhya,
PG and Research Department of Chemistry, Holy Cross College, Affiliated to Bharathidasan University, Tiruchirappalli-620002, Tamil Nadu, India.

A. Arputharaj,
Department of Electronics, St. Joseph’s College, Affiliated by Bharathidasan University, Tiruchirappalli-620002, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/NAMMS-V7/article/view/11043

A Case Report on Lower Motor Neuron Lesion Secondary to Ramsay Hunt Syndrome | Chapter 12 | New Advances in Medicine and Medical Science Vol. 7

 Ramsay Hunt condition is an illness provoked by the varicella zoster virus namely characterized by severe facial friendly, inner ear dysfunction, and herpetic eruptions on the auricle and outside ear waterway. Ramsay Hunt Syndrome can result in hearing misfortune, hence it should to conduct otoscopic and audiometric tests.  A case report of Ramsey Hunt Syndrome which is exceptional in dental clinic, often misdiagnosed and not widely documented in composition. Early detection and mediation with antiviral and corticosteroids is essential in improving consequence of the disease. Here, we present a case report of Ramsay hunt disease causing lower motor neuron injury.

Author(s) Details:

Sugandha Arya,
Department of Oral Medicine Diagnosis and Radiology, RR Dental College and Hospital, Udaipur, Rajasthan, India.

Amreen Aijazuddin,
Department of Pedodontics, Villa18, Street 607, Area 43, PO Box 35410, Doha, Qatar.

Tanvi Sharma,
Department of Orthodontics, 412 Luzon Cres, Mississauga, ON L5B 3W8, Canada.

Khushbu Lamba,
Department of Oral and Maxillofacial Surgery, Jaipur Dental College, Jaipur, Rajasthan, India.

Monika Tanwar,
Department of Oral and Maxillofacial Surgery, SGT University, Gurugram, Haryana, India.

Nowsheen Yaqoob,
Dept of Oral Pathology and Microbiology, Pacific Dental College and Hospital, Udaipur, Rajasthan, India.

Please see the link here: https://stm.bookpi.org/NAMMS-V7/article/view/11042

Novel Approach for Poor Ovarian Reserve with Autologous Platelet Rich Plasma (PRP) Therapy| Chapter 11 | New Advances in Medicine and Medical Science Vol. 7

 The present study was attended to observe the influence of platelet rich plasma infusion through calculation of AMH and AFC values and gestation outcomes. Though ovarian becoming older is a normal process but the term Poor ovarian reserve (POR) implies when the condition and quantity of the follicular pool decreases in mothers with generative age groups. Sometimes the condition becomes an obstacle for gestation and compromising pregnancy.  It may be seen in state-of-the-art years of generative life or without some reason or may happen in young women accompanying different etiological factors. Women accompanying poor ovarian reserve concede possibility be evaluated correctly and individualising their therapeutic strategies for optimizing the fame rate. Majority of women accompanying POR need to undergo artificial fertilization to achieve gestation. Sometimes ovum gift and embryo gift are not acceptable to some couples for disturb-social reason or conscientious reason. To improve the position many treatment approaches have been intentional. Among them individual of the novel approaches is Autologous platelet rich plasma healing.This prospective observational study was exhausted the department of generative endocrinology and infertility from July 2019 to June 2022. A total of 60 inmates with weak ovarian reserve were recruited maintaining addition and exclusion tests.At first cycle, distinguished to baseline counts, mean±SD AMH had increased by 0.04±0.15 ng/dl, and mean±SD AFC had raised by 1.34±1.89 in number. During second cycle post-PRP, the mean distinctness of AMH and AFC was 0.18±0.21 ng/dl and 2.17±1.71 in a positive tone. By final follow-up, gestation rate was 20% among cases. Ovarian PRP infusion had a  gestation success rate of 23.33%, which was comparable to other prior studies with identical short follow-up history. 18,21-23 PRP had existed proven expected an effective means for ovarian rejuvenation in terms of AMH and AFC in the study.Following PRP infusion, the study proverb a considerable bettering in AMH and AFC values. Both results gradually enhanced; an increase in AMH values was visualized up to the second post-PRP period, while an increase in AFC was shown until the third cycle post-PRP. Twelve (12) of the 60 subjects (20%) were pregnant. PRP ovarian situation resulted in revised oocyte and embryo quality in nearly three-fourths of patients and use of this medicine would therefore likely increase the success rate of IVF eras in poor responders.

Author(s) Details:

Jesmine Banu,
Department of Reproductive Endocrinology and Infertility, BSMMU, Dhaka, Bangladesh.

Mostafa Tarique,
Department of Reproductive Endocrinology and Infertility, BSMMU, Dhaka, Bangladesh.

Nishat Jahan,
Department of Gynecology, Nabinagar Upazila Health Complex, Brahmanbaria, Bangladesh.

Nastaran Lasker,
Department of Reproductive Endocrinology and Infertility, BSMMU, Dhaka, Bangladesh.

Nighat Sultana,
Department of Reproductive Endocrinology and Infertility, BSMMU, Dhaka, Bangladesh.

Chowdhury Faisal Alamgir,
Department of Urology, New Cross Hospital, The Royal Wolverhampton NHS Trust, United Kingdom.

Maliha Darmini,
Department of Gynecology, Mymensingh Medical College and Hospital, Mymensingh, Bangladesh.

S. M. Munira,
Department of Reproductive Endocrinology and Infertility, BSMMU, Dhaka, Bangladesh.

Please see the link here: https://stm.bookpi.org/NAMMS-V7/article/view/11041

An Overview on Glutamate Dehydrogenase and Its Clinical Applications| Chapter 10 | New Advances in Medicine and Medical Science Vol. 7

 The aim concerning this chapter is an overview of current knowledge about Glutamate dehydrogenase (GLDH) in dispassionate applicability and possible hints for further search. GLDH is applicable as a marker of addiction, maintenance of abstinence and repetition of alcohol use in daily practice, nevertheless allure role as an indirect flag in determining neurodegenerative processes in the mind offers limited help.In comparison to other indicators of alcoholism is GLDH equally correct. Time aspect deliberate serum GLDH activity is an ideal gravestone of alcoholism since it is exalted in alcohol abuse but its venture declines promptly subsequently the last alcohol intake in intoxicating dependent subjects and the change ends long enough to be smart to be evaluated.  Combinations of intoxicating markers increase sensitivity and belittle specificity.The kinetics of blood corpuscle GLDH activity is a particular marker of alcohol dependence in addition to of the cessation of drinking intoxicating. Alcohol consumption reduces GLDH project to some extent and consecutively it take care of lead to increased protein result and strengthen of belittled leukocyte protective skill.The gradually decreased GLDH venture over life may have few contribution when aging the same as the GLDH endeavor in leukocytes diminishes with growing up. The decrease in GLDH activity in the cerebrospinal fluid at neurodegenerative disorders concede possibility be one of the reasons for the neuroexcitotoxic glutamate effect.

Author(s) Details:

Matej Kravos,
ZPA Dr. Kravos, Trg Svobode 26, 2310 Slovenska Bistrica, Slovenia and The Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Glagoljaška ulica 8, 6000 Koper, Slovenia.

Please see the link here: https://stm.bookpi.org/NAMMS-V7/article/view/11040

ST-Elevated Myocardial Infarction Presented with Giant Coronary Artery Ectasia | Chapter 9 | New Advances in Medicine and Medical Science Vol. 7

 The present record of what happened highlights about giant coronary channel ectasia presenting accompanying ST elevation myocardial infarction. “Coronary channel ectasia (CAE) is an aneurysmic abnormality of the artery from diffuse extension, with a luminal diameter 1.5× more off-course than that of adjacent rational segments.A 56-year-traditional diabetic who does not smoke showed up with box for storage pain that had lasted more than twelfth hours. He was hemodynamically stable during the test, and the cardiac auscultation was unremarkable.Repeat ECG later loading with DAPT and heparin demonstrated ST-segment resolution, that was consistent accompanying sinus rhythm and vulgar of anteroseptal myocardial infarction. An echocardiogram disclosed hypokinesia of the anterior walls at the top and the anteroseptal region, with a 56% LV expulsion fraction. Coronary angiogram told Non-obstructive giant ectatic coronaries with slow contrast approval, patient had an episode of ventricular tachycardia all the while a coronary angiogram, DC cardioverted. The patient was originally on parenteral LMWH and DAPT. He was discharged with antiplatelet (Aspirin 75 mg occurring every day) and anticoagulants (Rivaroxaban 2.5 mg 12th hourly), beta-blocker. Cardiac CT disclosed Mild coronary channel disease with a calcium score – 30, and no meaningful coronary artery blockage. Diffusely ectatic coronary channels.“Initial studies have recommended the use of long-term spoken anticoagulation on the premise of an increased risk of loss of consciousness fromblockage in vein or artery in ectatic segments.

Author(s) Details:

K. Dhamodaran,
Apollo Main Hospitals, Chennai, TN, India.

Abhishek Kasha,
Apollo Main Hospitals, Chennai, TN, India.

Please see the link here: https://stm.bookpi.org/NAMMS-V7/article/view/11039

Applying Different Innovative Ideas in Reduction of Post-operative Adhesion Formation: A Systematic Review and Meta-analysis | Chapter 8 | New Advances in Medicine and Medical Science Vol. 7

 Development of adhesions is ultimate common significance of intra-abdominal and pelvic enucleation and a significant, still poorly recognizable, reason of melancholy in post-operative patients.. Use of ‘good surgical technique’and use of PRP (red body fluid rich plasma) is recommmended as a earlier step in stop of adhesions. However, confirmation is needed for the evidence for various surgical techniques to defeat adhesion establishment. This review add to the expanding pool of information by illuminating determinants that certainly influence the incident of adhesions.The PubMed database was used to conduct a search for all suitable English-language items in the literature, which were therefore evaluated accompanying a focus on the risk determinants for the development of post-operative adhesions. Each item's reference lists were further examined to find some additional pertinent everything.A new ray of predict adhesion stop in the form of plasma rich protein (PRP) is good option. Various determinants have been proved to directly exaggerate the risk of post-operative adhesion growth; namely, sure genetic polymorphisms in the interleukin-1 receptor foe, increased estrogen exposure, and endometriosis. In addition, many determinants are known to improve the chance of fibrosis, thereby growing the possibility of adhesion incident concomitantly.28 documents with 27 studies have existed included for a systematic review. Of these, 17 studies were worthy for meta-analysis and 11 for subjective assessment only. The predominance of adhesive small bowel obstacle was not significantly decreased by any of the techniques that were distinguished. The rate of pregnancy raised following subserous fixation of stitching knots in a small, low-quality trial. However, distinguished to open surgery, laparoscopic abscission had a lower incidence of adhesions (relative risk (RR) 0.14; 95% assurance interval (CI): 0.03-0.61) and non-peritoneal closure (RR 0.36; 95% CI: 0.21-0.63).The essay reviewed in this place paper will help to explicit future research in understanding of the mechanisms that focus on the connection of certain determinants with incident of adhesions. This information will be important in the plotting appropriate preventative and situation techniques.None of the distinguishing techniques that were compared were smart to lower the two chief grip-related dispassionate consequences, small bowel obstacle and infertility. The meta-study contributes little evidence for the surgical law that usage of fewer obtrusive techniques, launch of fewer offshore bodies or causing slight ischaemia decrease the range and severity of adhesions. Platelet-rich red body fluid has a diminishing effect on the postoperative peritoneal adhesions in rats.

Author(s) Details:

Rekha Rani,
Department of Obstetrics & Gynaecology, S.N.M.C., Agra, India.

Shikha Singh,
Department of Obstetrics & Gynaecology, S.N.M.C., Agra, India.

Urvashi,
Department of Obstetrics & Gynaecology, S.N.M.C., Agra, India.

Ruchika Garg,
Department of Obstetrics & Gynaecology, S.N.M.C., Agra, India.

Neelam Singh,
Department of Obstetrics & Gynaecology, S.N.M.C., Agra, India.

Sangita Sahu,
Department of Obstetrics & Gynaecology, S.N.M.C., Agra, India.

Monica Golani,
Department of Obstetrics & Gynaecology, S.N.M.C., Agra, India.

Please see the link here: https://stm.bookpi.org/NAMMS-V7/article/view/11038

The Impact of Morphine Withdrawal on Brain Activity | Chapter 7| New Advances in Medicine and Medical Science Vol. 7

One of the basic health issues that place significant business-related and social strains on institution around the world is drug misuse, that increases mortality, disadvantage, and the need for medical services. This unit highlights the exercises of GABA-catabolizing enzymes (succinate dehydrogenase (SDH), SSA-dehydrogenase (SSA-DH), and GABA-transaminase (GABA-T) changed in the cerebellum and thalamus of rats later morphine removal (MW). Only the thalamus experienced consistent alterations in substance causing chemicals to split into simpler substances activity later a 24-hour morphine self-restraint. The activation of SDH and GABA-change was determined in both intellect areas examined after 3 and 7 days of morphine retraction. A possible clarification for the observed changes is that persistent anesthetic intoxication recalls counteradaptation occurrences in GABAergic neurons.

Author(s) Details:

Husam Abazid,

Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied Science Private University, Amman 11931, Jordan.

Please see the link here: https://stm.bookpi.org/NAMMS-V7/article/view/11037