The present study examined the presence of distinguishing PDE-5 inhibitors in the most popular retailed liquid herbal amount in Bangladesh by HPLC system to confirm their cautious use. Cyclic nucleotide phosphodiesterases (PDE) is a ubiquitous catalyst in the human cell that is the essential manager of cyclic nucleotide indicating with diverse physiologic functions.A reversed-stage high-performance liquid chromatographic (HPLC) procedure with a photodiode array (PDA) indicator system has happened developed and validated for fact-finding the presence of artificial phosphodiesterase 5 (PDE-5) enzyme inhibitor as an contaminant in traditional herbaceous products. Nine of the liquid preparations (maple syrup), Balarista (A), Jinsant (B), Jernide (C), Bolarist (D), Sree Gopal Oil (E), Menostroge (F), Enerton (G), Ginseng (H) and Ginsin Plus (I), of six companies form local display of Bangladesh were investigated. The results indicated that the herbaceous companies of Bangladesh use many of synthetic PDE–5 inhibitors such as sildenafil citrate in their formulations. Some merchandise even contain a extreme amount of sildenafil citrate compared to others.All the output (A–I) were found to hold sildenafil citrate as an adulterant. HPLC peak of the contaminant was confirmed by comparing memory time, UV ranges generated by the PDA indicator, and peak spiking with the genuine sample of sildenafil citrate. The quantity of sildenafil citrate in A, B, C, D, E, F, G, H, and I syrups were found expected 17, 22, 26, 25, 10, 24, 29, 22, and 17 mg/100 ml, respectively.According to our study, sildenafil citrate was found to be an contaminant in all of the judged liquid herbal preparations secondhand for erectile disfunction. Along with different PDE-5 inhibitors, sildenafil citrate carries solid risks for adverse effects and likely drug interactions. The illegal addition of this artificial agent, sildenafil, to herbaceous products poses a grave threat that take care of result in lethal consequences. In order to reduce potential hazards to subjects, it is vital that Bangladesh's drug supervisory agency acknowledges these judgments and swiftly implement inevitable measures to minimize future risks to patients.
Author(s) Details:
Chowdhury Faiz Hossain,
Department
of Pharmacy, East West University, A/2 Jahuru Islam Avenue, Jahurul Islam City,
Aftabnagar, Dhaka-1212, Bangladesh.
Mohammad
Al-Amin,
Department
of Pharmacy, East West University, A/2 Jahuru Islam Avenue, Jahurul Islam City,
Aftabnagar, Dhaka-1212, Bangladesh and Department of Pharmaceutical Chemistry,
School of Pharmaceutical Sciences, Universiti Sains Malaysia, USM-11800,
Penang, Malaysia.
Gazi Nurun Nahar Sultana,
Centre for Advanced Research in Sciences (CARS), University of
Dhaka, Dhaka-1000, Bangladesh.
Please see the link here: https://stm.bookpi.org/NAPR-V4/article/view/10998
No comments:
Post a Comment