Toxicity Caused by Low Dose Chronic Exposure of Chromium in Male Albino Rats | Chapter 2 | Novel Aspects on Pharmaceutical Research Vol. 5

 This episode evaluate the effect of depressed doses chronic uncovering to chromium VI (K2Cr2O7) on various haematological and biochemical parameters in male light rats.  Chromium is one of the bigger environmental poisonous that effect human health. It is individual among the eight most common contaminant heavy metals filed by the Environment Protection Agency.Toxic effect of incessant exposure to chromium at depressed environmentally relevant measure is recently recognized and less intentional. Twenty four adult male waster rats (70±10 days) consideration (170±10 gm) were used in the study. The animals were protect in polypropylene cages in institutional animal house under regulated condition of temperature (25±2ºC) and sane day/midnight schedule (12 L : 12 D). Male albino rats (160±10 gm) taken 1/25, 1/50 and 1/100 of reported spoken LD50 dose of chromium VI (K2Cr2O7) for 90 consecutive days. After situation, various haematological and biochemical limits were evaluate.Exposure to chromium VI at 1/25 LD50 prescription decreased allotment gain in body weight and weakened  the weight of the organs along with increase in the pressure of liver and kidney. The biochemical study in our study showed an increase in activities of enzymes alanine aminotransferase, substance causing chemicals to split into simpler substances aspartate aminotransferase, creatinine and urea nitrogen level with a decline in protein and albumin levels. With an increase in coagulating time, cell with hemoglobin, white blood cell, platelet, and haemoglobin aggregation numbers decreased. In unprotected rats, both the overall sperm count and action were decreased. There were decrease in red body fluid protein and albumin concentration, accompanying increase in plasma sweet liquid and cholesterol level. The activity of enzyme alanine aminotransferase and substance causing chemicals to split into simpler substances aspertate aminotransferase were stimulated in medicated rats.  The results of the study revealed that incessant low lot exposure to chromium VI developed in a toxic effect in experimental male light rats.

Author(s) Details:

Soma Choudhuri,
Department of Physiology, Tripura Medical College and Br. B.R. Ambedkar Teaching Hospital, Hapania, Agartala, Tripura – 799014, India.

Dipayan Choudhuri,
Department of Human Physiology, Tripura University (A Central University), Suryamaninagar, Agartala, Tripura – 799022, India.

Please see the link here: https://stm.bookpi.org/NAPR-V5/article/view/11046