Toxicity Caused by Low Dose Chronic Exposure of Chromium in Male Albino Rats | Chapter 2 | Novel Aspects on Pharmaceutical Research Vol. 5

 This episode evaluate the effect of depressed doses chronic uncovering to chromium VI (K2Cr2O7) on various haematological and biochemical parameters in male light rats.  Chromium is one of the bigger environmental poisonous that effect human health. It is individual among the eight most common contaminant heavy metals filed by the Environment Protection Agency.Toxic effect of incessant exposure to chromium at depressed environmentally relevant measure is recently recognized and less intentional. Twenty four adult male waster rats (70±10 days) consideration (170±10 gm) were used in the study. The animals were protect in polypropylene cages in institutional animal house under regulated condition of temperature (25±2ºC) and sane day/midnight schedule (12 L : 12 D). Male albino rats (160±10 gm) taken 1/25, 1/50 and 1/100 of reported spoken LD50 dose of chromium VI (K2Cr2O7) for 90 consecutive days. After situation, various haematological and biochemical limits were evaluate.Exposure to chromium VI at 1/25 LD50 prescription decreased allotment gain in body weight and weakened  the weight of the organs along with increase in the pressure of liver and kidney. The biochemical study in our study showed an increase in activities of enzymes alanine aminotransferase, substance causing chemicals to split into simpler substances aspartate aminotransferase, creatinine and urea nitrogen level with a decline in protein and albumin levels. With an increase in coagulating time, cell with hemoglobin, white blood cell, platelet, and haemoglobin aggregation numbers decreased. In unprotected rats, both the overall sperm count and action were decreased. There were decrease in red body fluid protein and albumin concentration, accompanying increase in plasma sweet liquid and cholesterol level. The activity of enzyme alanine aminotransferase and substance causing chemicals to split into simpler substances aspertate aminotransferase were stimulated in medicated rats.  The results of the study revealed that incessant low lot exposure to chromium VI developed in a toxic effect in experimental male light rats.

Author(s) Details:

Soma Choudhuri,
Department of Physiology, Tripura Medical College and Br. B.R. Ambedkar Teaching Hospital, Hapania, Agartala, Tripura – 799014, India.

Dipayan Choudhuri,
Department of Human Physiology, Tripura University (A Central University), Suryamaninagar, Agartala, Tripura – 799022, India.

Please see the link here: https://stm.bookpi.org/NAPR-V5/article/view/11046

Phytochemical Appraisal and Evaluation of Effects of Aqueous Extract of Hypoestes rosea on Haematological Parameters of Acetaminophen – Induced Toxicity in Albino Rats| Chapter 10 | New Visions in Biological Science Vol.10

 Hypoestes rosea leaves are used as traditional medicine in most of Nigeria's Niger Delta regions and the western portion of Cameroon to treat a variety of diseases and sick states in children, such as fever, anaemia, and malaria. Despite its widespread use, research on its phytochemicals and effects on haematological parameters is limited. As a result, this study analyses its phytochemical evaluation and assesses the effects of an aqueous extract of Hypoestes rosea on haematological parameters in albino rats exposed to acetaminophen-induced toxicity. The goal of this study is to determine the phytochemical composition and haematological consequences of oral administration of crude extract leaves of Hypoestes rosea in albino rats. Acetaminophen, a regularly used painkiller and antipyretic, can be harmful and detrimental to essential organs of the body, disrupting homeostasis and erythropoiesis at high doses. In this study, phytochemical analysis of Hypoestes rosea leaves revealed the presence of flavonoids, tannins, alkaloids, terpenoids/steroids, saponins, carbohydrates, and cardiac glycosides, whereas the effects of an aqueous extract of Hypoestes rosea (AEHr) on haematological parameters of acetaminophen-induced toxicity in albino rats were assessed using acute (15 days) and sub-chronic (30 days) study durations A total of 156 adult albino rats weighing 180-220g were utilised in this investigation, 44 for the toxicity study and 112 for the extract control (EC), negative control (NC), positive control (PC), AEHr100mg/kg b w., AEHr 200mg/kg b w., and AEHr 300mg/kg b w. groups, each with six rats. After chloroform anaesthesia in a desiccator at the end of the study period, blood samples for haematological parameters were taken through jugular puncture (PCV, HB, RBC, WBC & Platelets). The results demonstrated that acetaminophen induction produced anaemia in albino rats, as evidenced by significant reductions in PCV, HB, RBC, and WBC levels. When comparing the PC group to the other experimental groups, P0.05 was found. However, different concentrations of aqueous extract of Hypoestes rosea were able to restore anaemia caused by acetaminophen induction to normal in a dose-dependent manner during different treatment stages in the acute and sub-chronic period. As a result, the findings of this study imply that Hypoestes rosea contains active components and phytochemicals that are responsible for its erythropoietic characteristics in rats, and that it should be studied further in higher mammals.

 

Author(s) Details:

E. Ogregade Ileimokumo,
Rivers State University / Bayelsa Medical University, Nigeria.


S. Bartimaeus Ebirien-Agana,
Rivers State University, Nigeria.


Igwe Felix,
Rivers State University, Nigeria.

G. Davies Tamuno-Emine,
Rivers State University, Nigeria.

Please see the link here: https://stm.bookpi.org/NVBS-V10/article/view/5989