Hypoestes rosea leaves are used as traditional medicine in most of Nigeria's Niger Delta regions and the western portion of Cameroon to treat a variety of diseases and sick states in children, such as fever, anaemia, and malaria. Despite its widespread use, research on its phytochemicals and effects on haematological parameters is limited. As a result, this study analyses its phytochemical evaluation and assesses the effects of an aqueous extract of Hypoestes rosea on haematological parameters in albino rats exposed to acetaminophen-induced toxicity. The goal of this study is to determine the phytochemical composition and haematological consequences of oral administration of crude extract leaves of Hypoestes rosea in albino rats. Acetaminophen, a regularly used painkiller and antipyretic, can be harmful and detrimental to essential organs of the body, disrupting homeostasis and erythropoiesis at high doses. In this study, phytochemical analysis of Hypoestes rosea leaves revealed the presence of flavonoids, tannins, alkaloids, terpenoids/steroids, saponins, carbohydrates, and cardiac glycosides, whereas the effects of an aqueous extract of Hypoestes rosea (AEHr) on haematological parameters of acetaminophen-induced toxicity in albino rats were assessed using acute (15 days) and sub-chronic (30 days) study durations A total of 156 adult albino rats weighing 180-220g were utilised in this investigation, 44 for the toxicity study and 112 for the extract control (EC), negative control (NC), positive control (PC), AEHr100mg/kg b w., AEHr 200mg/kg b w., and AEHr 300mg/kg b w. groups, each with six rats. After chloroform anaesthesia in a desiccator at the end of the study period, blood samples for haematological parameters were taken through jugular puncture (PCV, HB, RBC, WBC & Platelets). The results demonstrated that acetaminophen induction produced anaemia in albino rats, as evidenced by significant reductions in PCV, HB, RBC, and WBC levels. When comparing the PC group to the other experimental groups, P0.05 was found. However, different concentrations of aqueous extract of Hypoestes rosea were able to restore anaemia caused by acetaminophen induction to normal in a dose-dependent manner during different treatment stages in the acute and sub-chronic period. As a result, the findings of this study imply that Hypoestes rosea contains active components and phytochemicals that are responsible for its erythropoietic characteristics in rats, and that it should be studied further in higher mammals.
Author(s) Details:
E. Ogregade Ileimokumo,
Rivers State University / Bayelsa Medical University, Nigeria.
S. Bartimaeus Ebirien-Agana,
Rivers State University, Nigeria.
Igwe Felix,
Rivers State University, Nigeria.
G. Davies Tamuno-Emine,
Rivers State University, Nigeria.
Please see the link here: https://stm.bookpi.org/NVBS-V10/article/view/5989
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