An Overview on McCune-Albright Syndrome: Secondary Amenorrhea in a Case of Early Puberty without Gonadotropin | Chapter 9 | New Advances in Medicine and Medical Science Vol. 6

 The present case focal points the fact that careful test for syndromic features and intermittent follow up are important entirely cases of precocious adolescence. Precocious puberty is the appearance of subordinate sexual traits before the normal limit of age of beginning of puberty for the race and sexuality of the individual. It may be gonadotropin dependent or gonadotropin independent. A infrequent condition known as McCune-Albright condition (MAS) is characterised by the triad of café-au-lait macules, polyostotic stringy dysplasia of bone, and early puberty. Here, we express a case of childhood attack gonadotropin independent precocious adolescence who bestowed at 19 years of age accompanying secondary amenorrhea. Based on the dispassionate features and investigations, patient investigated to have MAS. She was given zoledronic acid immersion for fibrous dysplasia. Amenorrhea was treated accompanying medroxyprogesterone 10 mg daily for 14 days, trailed by low dose linked oral contraceptive therapy, following that menstrual cycles went on. Typically, the lesions of fibrous dysplasia are most active all the while childhood and preadulthood, tending to become inactive in adult life, new alive lesions being rare in adults. Bilateral infringement of the optic foramina was present in addition to multiple active polyostotic lesions, that is unusual at this age in spite of the fibrous dysplasia was asymptomatic at presentation.

Author(s) Details:

Sridhar Subbiah,
Department of Endocrinology, Government Rajaji Hospital and Madurai Medical College, Madurai, Tamil Nadu, India.

Roshan Nazirudeen,
Department of Endocrinology, Government Rajaji Hospital and Madurai Medical College, Madurai, Tamil Nadu, India.

Sundari Natarajan,
Department of Radiology, Government Rajaji Hospital and Madurai Medical College, Madurai, Tamil Nadu, India.

Vasanthiy Natarajan,
Department of Endocrinology, Government Rajaji Hospital and Madurai Medical College, Madurai, Tamil Nadu, India.

Sangumani Jayaraman,
Department of Endocrinology, Government Rajaji Hospital and Madurai Medical College, Madurai, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/NAMMS-V6/article/view/10990