The aim was to cultivate and validate an easy, inexpensive, fast, reliable, reproducible, exact, and accurate reversed-step high-act liquid chromatography (RP-HPLC) technique for judging Nadifloxacin and Mometasone furoate in semisolid dose form. Mometasone Furoate is medium-substance corticosteroids used to treat skin conditions. The HPLC whole with a C-18(2) column (250 x 4.6 mm, atom size 5 µm) operating at a intuitiveness of 254 nm was used to carry out the chromatographic break-up. NADIREST-M, a cream with chlorocresol as a preservative, is the handy dosage form. As a result, the meddling of Chlorocresol was calculated as well, and skilled was no interference in the belief of both medications by judging system acceptable parameters (Chlorocresol peak has judgment greater than 2 from the peak of drug). In the concentration range of 50-130 µgmL-1 and 5-13 µgmL-1 Nadifloxacin and Mometasone Furoate individually, the detector answer was found linear accompanying linear regressed equating Y=15116X-365319 and Y=52717X-184314. In the assay of NADI, 99.12% and MOM 99.77% of the drug was recovered. As per ICH necessities, this method demonstrated acceptable validation for all tests such as accuracy, extent of object, specificity, accuracy, range, ruggedness, strength, and repeatability. The study's findings demonstrated that it is beneficial for routinely deciding Nadifloxacin and Mometasone Furoate in semisolid pharmaceutical measure forms such as a oil.
Author(s) Details:
N. Naik Shreya,
Department of Pharmaceutical Quality Assurance,
ROFEL Shri G. M. Bilakhia College of Pharmacy, Vapi – 396191, Gujarat, India.
Desai
Shuchi,
Department
of Pharmaceutical Quality Assurance, ROFEL Shri G. M. Bilakhia College of
Pharmacy, Vapi – 396191, Gujarat, India.
Bijal Patel,
Department of Pharmaceutical Quality Assurance, ROFEL Shri G. M. Bilakhia
College of Pharmacy, Vapi – 396191, Gujarat, India.
Please see the link here: https://stm.bookpi.org/NAPR-V5/article/view/11054
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