This affiliate aimed to decide the extent of hepatoxicity and nephrotoxicity caused by a sub-never-ending exposure to a very low environmentally appropriate dose of hexavalent chromium in addition to ameliorative potential of selenium and source of nourishment E in combination against aforementioned chronic uncovering. The protective potential of selenium and source of nourishment E against hepatotoxicity and nephrotoxicity induced by chronic uncovering to a very low environmentally appropriate dose of hexavalent chromium was evaluated in male albino rats. Animals (six rats in each group) taken solution of potassium dichromate (K2Cr2O7) at a dosage of 1 mg / Kg b.w./day; sodium selenate (0.25 mg/kg bw) plus source of nourishment E ( 100 mg/kg bw) and supplementation of sodium selenate plus vitamin E along with K2Cr2O7 answer ; control group received only water purified by distillation for ninety consecutive days. In the rats acted with K2Cr2O7, skilled was a significant decline in body pressure gain and an increase in liver and kidney weight, in addition to an increase in serum organic compound composed of carbon, cholesterol, urea, and creatinine levels and a drop in protein and albumin levels. The endeavors of serum enzymes, SGOT, SGPT, ACP and ALP were again increased in considered animals. The projects of enzymes CAT, SOD, GPx and the levels of GSH reduced significantly and level of MDA raised in K2Cr2O7 treated rats distinguished to control animals. Liver and sort tissues exhibited face of toxicity in chromium treated mammals. All the effects were everted in supplemented group. A significant increase in MDA level and a important decrease in CAT-SOD system and GPx- GSH action is a clear indication of oxidative stress, that might have induced functional and fundamental disruption in two together liver and kidney of chromium exposed mammals. In male albino rats, incessant exposure to K2Cr2O7 at a approximately low ecologically appropriate dose experienced to hepatotoxicity and nephrotoxicity brought on by oxidative stress; the belongings were mitigated by selenium and vitamin E supplementation.
Author(s) Details:
Soma Choudhuri,
Department of Physiology, Tripura Medical
College and Br. B.R. Ambedkar Teaching Hospital, Hapania, Agartala, Tripura –
799014, India.
Dipayan
Choudhuri,
Department
of Human Physiology, Tripura University (A Central University), Suryamaninagar,
Agartala, Tripura – 799022, India.
Please see the link here: https://stm.bookpi.org/NAPR-V5/article/view/11048
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