Phytochemical Analysis by HR-LCMS and In-vitro Anti - diabetic Potential of Michelia champaca Bark| Chapter 3 | Novel Aspects on Pharmaceutical Research Vol. 4

 The current study was proposed to explore the basic phytochemicals and HRLCMS was performed to separate and sequester the phytoconstituents present in Michelia champaca established on their memory time. Natural amount are organic fragments with a type of structural features and biological exercises that have evolved by way of long-term evolutionary theory and evolution. They are more reliable and more affordable than artificial products. The plant example for the proposed report was increased from Tirupati District of Andhra Pradesh in the month of February 2018. The consequences of HR-LCMS showed the vicinity of 15 phytochemical compounds. DL-Carnitine, Catechin, D-α-Tocopherol, Colchicine, Myricetin, Epicatechin, Quercetin, Epigallocatechin gallate, Quercetin-3β-D-glucoside, Kaempferol, Sorbic acid, Apocynin, Epigallocatechin gallate, myricetin 3-O-beta-D-galactopyranoside, Naringeninchalcone are the main compounds labeled. In the experimental models, the hindrance of enzymes such as -amylase and -glucosidase delays the rate of sweet liquid absorption and lowers level of glucose in blood levels. In HR-LCMS elucidation, the compounds like DL-Carnitine, Catechin, D-α-Tocopherol, Colchicine, Myricetin, Epicatechin, Quercetin, Epigallocatechin gallate, Quercetin-3β-D-glucoside, Kaempferol, Sorbic acid, Apocynin, Ellagic acid, myricetin 3-O-being tested-D-galactopyranoside, Naringeninchalcone were present in Michelia champaca (Bark). The IC50 values of α-amylase and α-glucosidase inhibitory exercise of HEMC was acquired expected 88.65 μg/mL and 71.28 μg/mL correspondingly. Positive control acarbose presented IC50 value of 52.94 μg/mL and 50.01 μg/mL similarly. The present data hinted that the extracts possess direct and forceful antioxidant activities through diversified mechanisms.

Author(s) Details:

Segu Prathyusha,
Department of Pharmacognosy, School of Pharmacy, Guru Nanak Institutions Technical Campus (Autonomous), Hyderabad – 501506, Telangana, India and Department of Pharmacognosy, Vels Institute of Science, Technology and Advanced Studies, Chennai – 600117, Tamil Nadu, India.

Malarkodi Velraj,
Department of Pharmacognosy, Vels Institute of Science, Technology and Advanced Studies, Chennai – 600117, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/NAPR-V4/article/view/11001