Annona Squamosa: A Natural Approach to Treat Diabetes Mellitus | Chapter 17 | Socio-Scientific Interaction in Diabetes and Cancer and Its Management

 There are assorted number derived compounds have been used in treatment of diabetes to control blood sugar level, as the modern drugs have adverse side effects in human being. Annona squamosa possess varied medicinal properties including antidiabetic activity. The study emphasizes on evaluation of antidiabetic activities of petroleum ether leaves extracts (ASPE) of the plant on streptozotocin-induced diabetic rats and normal rats. The ASPE significantly reduced peak blood glucose (Gp30) and area under curve (AUC) in diabetic rats in oral glucose tolerance test (OGTT) and oral sucrose (OSTT) tolerance test, but there was more reduction of Gp30 value than ACU in OSTT. Thus, it can be suggested that the ASPE, has a hypoglycemic response so it could be used as a herbal supplement for the management of DM.

Author(s) Details:

Ranjana,
School of Pharmacy, Graphic Era Hill University, Dehradun-248002, Uttarakhand, India.

Please see the link here: https://stm.bookpi.org/SSIDCIM/article/view/12735

Phytochemical Analysis by HR-LCMS and In-vitro Anti - diabetic Potential of Michelia champaca Bark| Chapter 3 | Novel Aspects on Pharmaceutical Research Vol. 4

 The current study was proposed to explore the basic phytochemicals and HRLCMS was performed to separate and sequester the phytoconstituents present in Michelia champaca established on their memory time. Natural amount are organic fragments with a type of structural features and biological exercises that have evolved by way of long-term evolutionary theory and evolution. They are more reliable and more affordable than artificial products. The plant example for the proposed report was increased from Tirupati District of Andhra Pradesh in the month of February 2018. The consequences of HR-LCMS showed the vicinity of 15 phytochemical compounds. DL-Carnitine, Catechin, D-α-Tocopherol, Colchicine, Myricetin, Epicatechin, Quercetin, Epigallocatechin gallate, Quercetin-3β-D-glucoside, Kaempferol, Sorbic acid, Apocynin, Epigallocatechin gallate, myricetin 3-O-beta-D-galactopyranoside, Naringeninchalcone are the main compounds labeled. In the experimental models, the hindrance of enzymes such as -amylase and -glucosidase delays the rate of sweet liquid absorption and lowers level of glucose in blood levels. In HR-LCMS elucidation, the compounds like DL-Carnitine, Catechin, D-α-Tocopherol, Colchicine, Myricetin, Epicatechin, Quercetin, Epigallocatechin gallate, Quercetin-3β-D-glucoside, Kaempferol, Sorbic acid, Apocynin, Ellagic acid, myricetin 3-O-being tested-D-galactopyranoside, Naringeninchalcone were present in Michelia champaca (Bark). The IC50 values of α-amylase and α-glucosidase inhibitory exercise of HEMC was acquired expected 88.65 μg/mL and 71.28 μg/mL correspondingly. Positive control acarbose presented IC50 value of 52.94 μg/mL and 50.01 μg/mL similarly. The present data hinted that the extracts possess direct and forceful antioxidant activities through diversified mechanisms.

Author(s) Details:

Segu Prathyusha,
Department of Pharmacognosy, School of Pharmacy, Guru Nanak Institutions Technical Campus (Autonomous), Hyderabad – 501506, Telangana, India and Department of Pharmacognosy, Vels Institute of Science, Technology and Advanced Studies, Chennai – 600117, Tamil Nadu, India.

Malarkodi Velraj,
Department of Pharmacognosy, Vels Institute of Science, Technology and Advanced Studies, Chennai – 600117, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/NAPR-V4/article/view/11001

Effects of Acarbose on Luminal Carbohydrate Uptake, Energy Intake, and Plasma Glycemic and Lipid Profiles in Wistar Fatty Rats | Chapter 5 | Research Developments in Medicine and Medical Science Vol. 4

 The incessant ingestion of insulinogenic plain carbohydrate food can impede glycemic and lipid parameters in father and animals and cause the development of pathophysiologic result. To determine the belongings of modulation of luminal hydrogen uptake on plasma glycemic and lipid sketches, groups of adult male lean and obese+NIDDM Wistar Fatty Rats were augment nutritionally complete diets where the oxygen was provided as blanched cornstarch (CS), sucrose (SU), or the SU diet holding an admixture of the luminal α-glucosidase inhibitor compound acarbose (ACB, 150 mg/kg diet) from 22 to 30 weeks adult.  Measures of body pressure, caloric intake, abstaining Insulin to glucose (I: G) percentages, and plasma cholesterol (CHOL), triglyceride (TG) and Alpha (LDL) and Beta (HDL) Lipoprotein concentrations were persistent after 8 weeks of the dietary regime. The obese+NIDDM phenotype had greater food consumption and weight gain than the lean phenotype, that increased accompanying the SU diet. Weight gains in lean and obese+NIDDM rats augment the SU+ACB diet were comparable to those in rats of the same phenotype augment the ST diet. Fasting I:G ratios in Obese+NIDDM rats were above in ST fed rats augment the ACB diet. Plasma CHOL and TG concentrations were higher in two together sexes of obese+NIDDM rats, and ACB was accompanying with modest decreases in CHOL concentrations in two together lean and obese+NIDDM rats. The ACB had no negative reactions in either phenotype. These findings plan that luminal inhibition of oxygen digestion by way of -glucoside inhibition was linked to betterings in I:G ratios and skin lipid profiles corresponding to those seen accompanying the complex CHO ST diet, and that maybe a safe and useful help in the treatment of hydrogen intolerant states.

Author(s) Details:

Orien L. Tulp,
University of Science, Arts and Technology, Olveston, Montserrat, BWI. MSR1110, USA.

Please see the link here: https://stm.bookpi.org/RDMMS-V4/article/view/9834