Positive Impacts of Olive Oil Enriched with Lycopene on the Plasma Antioxidant and Anti-Inflammatory Status of Hypercholesterolemic Patients | Chapter 2 | Disease and Health: Research Developments Vol. 10

Atherosclerosis is a chronic inflammatory disease that is responsible for several cardiovascular events such as ischemic heart disease, coronary artery disease, peripheral artery disease, and ischemic stroke. Olive oil and lycopene are foods that have potent antioxidant activity. The objective was to determine the effects of consumption of olive oil enriched with lycopene on oxidative stress biomarkers in hypercholesterolemic subjects. The study product sample “lycopene-olive oil” consisted of virgin olive oil enriched with lycopene (350 mg/L). Patients (n = 80) were recruited from the town of Moralzarzal, Madrid, Spain, including healthy men and women with cholesterol levels over 220 mg/dL. The effects of oil enriched with lycopene extract daily intake were examined for 1 month on plasma antioxidant capacity, lipid profile (triacylglycerols, total cholesterol, HDL-C; LDL-C, ox-LDL), biomarkers of oxidative stress, and inflammatory markers related to atherosclerosis risk (C-reactive protein (CRP), IL-6; sDC4L) in subjects with hypercholesterolemia (cholesterol > 220 mg/dL). In the group consuming olive oil-lycopene, significant increases (p < 0.05) in the levels of plasma lycopene concentration (0.146 ± 0.03 versus 0.202 ± 0.04 (µmol/L)), α-carotene (0.166 ± 0.064 versus 0.238 ± 0.07) and β-carotene (0.493 ± 0.187 versus 0.713 ± 0.221) were observed. These results are linked with the increases of plasma antioxidants and decrease in biomarkers of oxidative stress (carbonyl groups, malondialdehyde and 8-hydroxy-deoxyguanosine) observed in the hypercholesterolemic group. In relation to the lipid profile, a significant decrease was observed in the levels of ox-LDL (781 ± 302 versus 494 ± 200), remaining unchanged in the levels of TG, cholesterol, HDL and LDL-C. Regarding inflammatory biomarkers, the levels of CRP and IL-6 decreased significantly. The positive results obtained in this study support the use of olive oil enriched with lycopene to reduce the risk of coronary disease. The results also indicate that triglyceride, cholesterol, LDL, and HDL levels did not change significantly. However, ox-LDL levels decreased significantly only in the group supplemented with lycopene-olive oil. In conclusion, this study suggests that foods containing olive oil and lycopene can significantly contribute to reducing LDL-induced oxidative stress.

 

Author (s) Details

Meryem El Ouardi
Predepartmental Unit of Medicine, Physiology Section, Faculty of Health Sciences, Universidad Jaume I, 12006, Castelló de la Plana, Spain.

 

Guillem Garcia-Llorens
Predepartmental Unit of Medicine, Physiology Section, Faculty of Health Sciences, Universidad Jaume I, 12006, Castelló de la Plana, Spain.

 

Victoria Valls-Belles
Predepartmental Unit of Medicine, Physiology Section, Faculty of Health Sciences, Universidad Jaume I, 12006, Castelló de la Plana, Spain.

 

 

Please see the book here:- https://doi.org/10.9734/bpi/dhrd/v10/5033

Synthesis and Biological Applications of Ferrocenyl Amino Acids, Sugar and Nucleic Acids Derivatives | Chapter 1 | Advancements in Science and Technology: Paving the Way to a Sustainable Future

Ferrocene, known for its aromaticity, relative lipophilicity, and stable redox properties, has been widely explored in functional molecules due to its unique chemical characteristics. Despite being an organometallic compound, ferrocene and some derivatives maintain stability in aqueous and aerobic environments. Its industrial applications span diverse fields such as petroleum, plastics, textiles, metallurgy, and catalysis. Medicinally, ferrocene and its derivatives demonstrate cytotoxic, antitumor, antimalarial, and antianemic properties, making ferrocene-conjugated biomolecules particularly promising. One approach to enhance ferrocene’s water solubility and biocompatibility is through covalent attachment to biomolecules like amino acids, carbohydrates, and nucleic acids. These conjugates exhibit significant structural, electrochemical, and biological properties. This chapter reviews recent advancements in the synthesis of ferrocene-conjugated carbohydrates and amino acids, focusing on methods such as thio-alkylation, click chemistry, and amide linkage formation. Overall, the chemical versatility and bioactivity of ferrocene derivatives highlight their potential for future applications in medicinal and material science.

 

Author (s) Details

Dr. Anija Mol T Philip
Department of Chemistry, Hislop College, Nagpur, Maharashtra, India.

 

Dr. Mayur V Khedkar
Department of Chemistry, Hislop College, Nagpur, Maharashtra, India.

 

Dr. Shoeb R Khan
Department of Chemistry, Hislop College, Nagpur, Maharashtra, India.

 

Dr. Shibin Chacko
Department of Chemistry, Hislop College, Nagpur, Maharashtra, India.

 

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-49473-39-3/CH1

Some Characteristics of Kars Gruyere Cheese, One of Turkey's Local Cheeses | Chapter 6 | Research Perspectives of Microbiology and Biotechnology Vol. 2

There are many types of cheese produced locally and offered for sale in Turkey. Among these cheeses, Kars Gruyere cheese has an important place. Gruyere cheese, which is one of the few European-type cheese types produced in Turkey, has an economic value and is appreciated by consumers; Differs greatly from other cheese types because it is full-fat and has a very different aroma. Kars Gruyere cheese is a very high fat, ripe, nutritious and unique cheese type in terms of its preparation. Gruyere cheese produced in Kars province is a dairy product rich in animal protein, which our people lack to a great extent, and it is more valuable than many animal foods with an average of 32.22% protein. In this review, information is given about the chemical, microbiological and physicochemical properties of Kars Gruyere cheese, which is produced by traditional methods in dairies.

Author(s) Details:

Asya Çetinkaya,
Department of Food Engineering, Engineering and Architecture Faculty, Kafkas University, TR-36100 Kars, Turkey.

Güven Gülbaz,
Department of Food Engineering, Engineering and Architecture Faculty, Kafkas University, TR-36100 Kars, Turkey.

Please see the link here: https://stm.bookpi.org/RPMAB-V2/article/view/14121

Sonography of the Hepatic Spans and Their Correlation to Dyslipidaemia in a Nigerian Population | Chapter 2 | Advanced Concepts in Medicine and Medical Research Vol. 1

The sample analysis for this investigation was performed in the private laboratory of the HMG Hospital in Rivers State, which is part of the University of Port Harcourt Teaching Hospital. Technological developments such as solid state circuitry, real time imaging, colour and power Doppler, transvaginal sonography and 3/4D imaging have been seized by clinical researchers to enhance the investigation and management of patients in areas as diverse as assessment of fetal growth and wellbeing, screening for fetal anomalies, prediction of pre-eclampsia and preterm birth, detection of ectopic gestation, evaluation of pelvic masses, screening for ovarian cancer and fertility management. A random sampling technique was employed to select the respondents, while the Taro-Yamene formula was used to calculate the sample size and data analyzed with SPSS version 20. The respondents were mainly aged 30 - 39 years, 12 (40.00%), mainly females, 20 (66.67%) and obese, 16 (53.33%). They were also mainly Christians, 25 (83.33%), of Ijaw descent 20 (66.67%) and civil/public servants, 13 (43.33%). The total cholesterol was the highest, 18 (60.00%), normal for triglyceride, 24 (80.00%), low for high density lipoprotein cholesterol, 22 (73.33%) and high for low density lipoprotein cholesterol, 14 (46.67%). Maximum liver span was statistically significant to triglyceride concentration; p-value (0.001) but not for total cholesterol; p-value (0.084), high density lipoprotein cholesterol; p-value (0.477) and low density lipoprotein cholesterol; p-value (0.317). Hepatic span is a predictive tool for the probable diagnosis of dyslipidaemia.

Author(s) Details:

Precious Belema Ibiabuo,
Akuku-Toru LGA, Abonnema, Rivers State, Nigeria.

Please see the link here: https://stm.bookpi.org/ACMMR-V1/article/view/12289

A Study on Ten-Year Risk Assessment of Cardiovascular Events among Adults Visiting a Tertiary Care Institution, Farrukhabad, India | Chapter 6 | Novel Research Aspects in Medicine and Medical Science Vol. 8

 Using the WHO/ISH Risk prophecy Chart at ten years, the study wanted to determine the CVD risk with adult patients from the inexact community the one visited the OPD of the Urban Health and Training Centre (UHTC). Cardiovascular disease (CVD) has enhance a significant community health problem moving national business-related and social growth, and ranks among the top causes of end of life in the world. Thus, society pay increasing consideration to the stop, control, and risk assessment of CVD. Cardiovascular ailments (CVDs) are a group of disorders of the heart and ancestry vessels, containing Myocardial infarction and stroke. Risk factors contained are both changeable and non-modifiable, like age, sexuality, blood pressure, hot status, total ancestry cholesterol and presence or omission of diabetes mellitus. In the above upbringing it is important to learn the risk of CVDs among subjects visiting UHTC of a tertiary care institute. Early discovery of risk probability will alert bureaucracy to modify the complicated risk factors to thwart the CVDs. In the department of Community Medicine, a cross-divided study was conducted from noble 2017 to January 2018. A total of 400 subjects were registered. Data were collected utilizing the World Health Organisation (WHO)/ISH ten years risk prophecy chart. Chi-square test was applied and level of importance were obtained at p profit <0.05. Majority (58.75%) of the population belonged to the teenager age group (30-50 age). There were 216 men and 184 females. Overall, 7.75% folk were diabetic, and 11.25% were smoker. Majority (69.5%) of people as political whole had less than 10% risk for CVD, and 5.75% crowd had ≥ 40% risk. With respect to total serum cholesterol, 8.25% had extreme level of cholesterol. Statistically significant friendship was observed middle from two points socio-economic rank (Modified Kuppuswami scale) and cardiovascular event (p<0.00001). Middle income group were depressed risk compared to possible choice p<0.00001. People with middle incomes and more immature age groups were more likely than those with reduced incomes and older age groups to expand CVDs in the future. Therefore, early behavior management grant permission prevent CVDs. Additionally, this study opens dismissal from responsibility for additional review into the relative importance of the differing CVD risk variables.

Author(s) Details:

Abha Ekka,
Department of Community Medicine, RSDKS, GMC, Ambikapur, Chhattisgarh, India.

Md. Naushad Alam,
Department of Community Medicine, MPTMC, Siddharthnagar, Uttarpradesh, India.

Shagufta Khatoon,
Department of Microbiology, MPTMC, Siddharthnagar, Uttarpradesh, India.

Please see the link here: https://stm.bookpi.org/NRAMMS-V8/article/view/12185

Cholesterol is Involved in Tumorigenesis and Its Potential Therapeutic Prospects | Chapter 7 | Novel Aspects on Pharmaceutical Research Vol. 5

 This division will help citizens accomplish the important function of cholesterol during cyst formation in addition to the importance of adjusting their diets, have a healthful lifestyle, and of bodily conditioning. Tumor cells are characterized by hasty growth and limitless replication potential; accordingly, their high energy and biosynthesis necessities need to be compensated, particularly the biosynthesis of cell membranes. Recent studies have proved that cholesterol, an essential component of cell membranes, has a meaningful impact on the development of tumours, invulnerable system dysregulation, and unhealthy changes in epigenetic mechanisms. Cholesterol biosynthesis is an extremely accepted phenomenon in creatures, the process is complicated. There is a growing interest on targeting cholesterol in the treatment of malignancy. First, it was comprehensively inspected the major function of cholesterol on oncogenicity, the therapeutic aims of cholesterol and its metabolites in tumor, and provide detailed awareness into the essential roles of cholesterol in arbitrating immune and epigenetic machines of the tumor microenvironment. It is believed that malignancy cells indulge excessive metabolic consequences of red body fluid cholesterol intake to maintain cancer progression, that may demonstrate why the level of serum cholesterol in few cancer victims is normal or even beneath normal ranges. Additionally, due to allure function in cholesterol metabolism, the gut microbiome is an basic facts of cancer mediation. To determine more therapeutic mediations in oncology, the most recent research on the potential aims of cholesterol and their metabolism was summarised.

Author(s) Details:

Yang Xi,
Department of Oncology, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Address: No.1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province-313000, China.

Zhou Yani,
Graduate School of Medical College of Zhejiang University, Address: No. 268 Kaixuan Road, Jianggan District, Hangzhou, Zhejiang Province-310029, China.

Mao Jing,
Graduate School of Second Clinical Medicine Faculty, Zhejiang Chinese Medical University, Address: No. 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang Province-310053, China.

Wu Yinhang,
Graduate School of Second Clinical Medicine Faculty, Zhejiang Chinese Medical University, Address: No. 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang Province-310053, China.

Hou Xiaohui,
Graduate School of Nursing, Huzhou University, Address: No. 1 Bachelor Road, Wuxing District, Huzhou, Zhejiang Province-313000, China.

Zhuang Jing,
Department of Nursing, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Address: No.1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province-313000, China.

Qi Quan,
Department of Oncology, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Address: No.1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province-313000, China.

Han Shuwen,
Department of Oncology, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Address: No.1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province-313000, China.

Please see the link here: https://stm.bookpi.org/NAPR-V5/article/view/11051

Effects of Aqueous Fruit Extract of Tamarindus indica on Body Weight, Lipid Profile, Some Electrolytes and Urea of Wistar Rats: Experimental Investigation| Chapter 8 | Current Topics on Chemistry and Biochemistry Vol. 8

 The aim concerning this study search out judge the belongings of liquid extract of T. indica  on the crowd burden, lipid characterization few electrolytes and urea of Wistar rats. The tamarind forest is well used to to a certain extent-dry domains of the torrid zone and can bear dryness environments rather well.  Twenty-five Wistar rats were delivered into four groups involving six rats each. Group I dressed as the control group, while Group II taken 100mg/kg of Aqueous extract, Group III taken 150mg/kg of Aqueous extract, and Group IV taken 200mg/kg of Aqueous extract. The presidency endure seven days, and The Animals were gone on the eighth era. The ancestry was fatigued by way of cardiac puncture and analysed accompanying a seeable spectrophotometer.   The verdicts granted that skilled was no important distinctness (p<0.05) in carcass burden of Wistar rats.  In the Test Groups; Serum cholesterol, reduced mass lipoprotein (LDL), High mass lipoprotein (HDL), Very Low-mass Lipoprotein and Triglycerides accompanied a important increase (p<0.05) distinguished to Group 1 that is the control Group but had a meaningful decrease (p<0.05) distinguished inside test groups. For electrolytes concentrations, potassium, Sodium, Chloride and Urea concentrations was meaningful at p<0.05.  According to the judgments, T. indica extract grant permission help to uphold a active burden, grant permission have hypolipidemic features, grant permission aid in frame equilibrium and fluid balance, and concede possibility likewise assist in preventing renal damage.

Author(s) Details:

I. P. Ekpe,
Department of Biochemistry, Veritas University, Abuja, Nigeria.

Dennis Amaechi,
Department of Biochemistry, Veritas University, Abuja, Nigeria.

B. N. Yisa,
Department of Biochemistry, Veritas University, Abuja, Nigeria.

O. G. Osarhiemen,
Department of Biochemistry, Veritas University, Abuja, Nigeria.

Please see the link here: https://stm.bookpi.org/CTCB-V8/article/view/9425

The Influence of High-Concentration Hydrogen-Rich Water for 24-Week on Body Composition, Blood Lipid Profiles, and Inflammatory Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial | Chapter 1 | Current Topics on Chemistry and Biochemistry Vol. 4

 

 The epidemic of metabolic syndrome has spread to every country. Obesity, hyperglycemia, and dyslipidemia are linked to it. The aftereffects of this disorder raise mortality rates and the risk of cardiovascular and neurological conditions. In addition to disrupting cellular homeostasis, the pathogenesis of metabolic syndrome is linked to dysregulation of redox and inflammatory state. It has been demonstrated that molecular hydrogen (H2) lowers oxidative stress, enhances cellular performance, and lowers chronic inflammation. Although H2-rich water (HRW) has been demonstrated in pre-clinical and clinical research to have positive effects on some aspects of the metabolic syndrome, it is unknown how long-term, high-concentration HRW would affect metabolic syndrome. 60 individuals with metabolic syndrome took part in a randomised, double-blinded, placebo-controlled  Following a one-week initial observation period during which baseline clinical data were collected, participants were randomly assigned to receive either a placebo or high-concentration HRW (> 5.5 millimoles of H2 per day) for 24 weeks. In comparison to placebo, high-concentration HRW supplementation substantially decreased blood cholesterol and glucose levels, attenuated serum haemoglobin A1c, and enhanced inflammatory and redox homeostasis indicators (P 0.05). H2 also caused a considerable drop in blood pressure as well as a modest decrease in waist-to-hip ratio and body mass index. These findings support earlier research showing high-concentration HRW may have therapeutic effects in reducing risk factors for metabolic syndrome and its associated complications.

Author(s) Details:

Tyler W. Le Baron,
Centre of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic and  Molecular Hydrogen Institute, Enoch, Utah, USA.

Ram B. Singh,
Hospital and Research Institute, Moradabad, India.

Ghizal Fatima,
Era Medical College, Lucknow, India.

Kumar Kartikey,
Hospital and Research Institute, Moradabad, India.

Jai P. Sharma,
Hospital and Research Institute, Moradabad, India.

Sergej M. Ostojic,
Applied Bioenergetics Lab, Faculty of Sport and PE, University of Novi Sad, Novi Sad, Serbia and  Faculty of Health Sciences, University of Pecs, Pecs, Hungary.

Anna Gvozdjakova,
Pharmacobiochemical Laboratory of 3rd Medical Department, Medical Faculty, Comenius University Bratislava, Bratislava, Slovakia.

Branislav Kura,
Molecular Hydrogen Institute, Enoch, Utah, USA.

Mami Noda,
Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Viliam Mojto,
Third Internal Clinic, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

Mohammad Arif Niaz,
Center of Nutrition Research, International College of Nutrition, Moradabad, India.

Jan Slezak,
Centre of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic.

Please see the link here: https://stm.bookpi.org/CTCB-V4/article/view/7804

Oil Yield Responses of Sunflower Plant in Indian Subcontinent | Chapter 6 | Emerging Challenges in Environment and Earth Science Vol. 4

The current study emphasises the outside characteristics of sunflower oil production facilities in India. PUFAs are absent from sunflower oil. It is a widely accepted hypothesis. However, if people want to enhance their health, they must be able to afford to buy. Today, consumers choose to purchase sunflower oil at the store rather than mustard oil. due to the usual diet's decreased lipid (unsaturated fatty acid and cholesterol) composition. Doctors advise against using mustard oil as a cooking medium for obese persons. Plants in good health flourish on acres of land. Large-scale farmers in India are already making money from sunflower fields. The oil used was sunflower oil rather than mustard oil. Cooking oil that is healthy is highly praised. Everyone is becoming more worried about human health as a result of media awareness (television and newspapers). Regular health exams are expected in MNC culture. People today are concerned about their health. You'll note that sunflower oil now predominates over mustard oil even in wayside inns. Sunflower oil without PUFAs is commonly accepted in modern society. The health of older people (those over 60) is seriously at risk due to heart disease brought on by fat molecule buildup in arteries.

Author (s) Details

Manju Das

Department of Oceanography, Techno India University, India.

S. Zaman

Department of Oceanography, Techno India University, India.

S. K. Biswas

Department of Civil Engineering, Planning and Architecture, TIU, India.

A. Mitra

Department of Marine Science, (C.U), India.

 

View Book :-  https://stm.bookpi.org/ECEES-V4/article/view/7580

A Minireview on Statin Therapy | Chapter 6 | Emerging Trends in Disease and Health Research Vol. 9

Statistics, case studies, chemical analysis, clinical experience, and other data all support the fact that statins have severe side effects. The emphasis will be on how crucial cholesterol metabolism is to brain health. The significance and effects of Statin therapy need to be reevaluated because the blood-brain barrier doesn't actually allow circulating blood to pass through, cells have a delicate balance of cholesterol metabolism, and they must independently manage their demands.

Author (s) Details:

Erich Ebner,
PD Dr. Med. Habil. Erich Ebner, Hoher Weg 2, 99425 Weimar, Germany.

Please see the link here: https://stm.bookpi.org/ETDHR-V9/article/view/7444

Structural Development of Atherosclerosis and Aspects of Coronary Heart Disease | Chapter 5 | Emerging Trends in Disease and Health Research Vol. 9

Discussion is held over the causes of arteriosclerosis, which leads to coronary heart disease. It seems ludicrous to explain arteriosclerosis's causes simply on the basis of morphological considerations at the molecular level. The structural importance of cholesterol in the human body cannot be overstated. It is regulated by the human body. Statin therapy must be rethought upon as a treatment choice once long-term statin medication observations reveal negative effects. Arteriosclerosis is brought on by a persistent ischemia state in the arterial artery wall. External perturbations that persist over time, such elevated blood pressure, might impair flow and thus bring about alterations in metabolism.

Author (s) Details:

Erich Ebner,
PD Dr. Med. Habil. Erich Ebner Hoher Weg 2, 99425, Weimar, Germany.

Please see the link here: https://stm.bookpi.org/ETDHR-V9/article/view/7443

Keys to Diagnosis and Management of Smith-Lemli-Opitz Syndrome | Chapter 14 | Current Practice in Medical Science Vol. 2

Smith, Lemli, and Opitz reported a novel condition that causes congenital mental retardation in 1964, describing it as having genital ambiguity, sexual dysgenesis, and mental retardation. This disease follows Down Syndrome and Fragile X Syndrome. Smith-Lemli-Opitz Syndrome (SLOS) affects between 1:20,000 and 1:40,000 Caucasians. SLOS is an autosomal recessive genetic condition with intrauterine onset and the third most common cause of congenital mental impairment. This book chapter's objective is to present the SLOS, together with all of its genetic, metabolic, malformational, and biochemical characteristics, as well as the likelihood of identification and diagnosis.

Author(s) Details:

Cristina-Crenguta Albu,

Department of Genetics, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 1st District, 020021, Bucharest, Romania.

Please see the link here: https://stm.bookpi.org/CPMS-V2/article/view/7353

Evaluating the Effects of 24-Week Intervention with High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Individuals with Metabolic Syndrome | Chapter 18 | New Horizons in Medicine and Medical Research Vol. 9

 The researchers want to see how HRW affects blood lipids, inflammation, oxidative stress, and glucose levels, as well as phenotypic alterations like body mass and waist-to-hip ratio. Molecular hydrogen (H2) has been shown to alleviate chronic inflammation, minimise oxidative stress, and enhance cellular function. Although preclinical and clinical research have demonstrated that H2-rich water (HRW) has promise benefits on particular characteristics of metabolic syndrome, the effects of long-term, high-concentration HRW in this common illness are still unknown. In 60 men and women with metabolic syndrome, we performed a randomised, double-blinded, placebo-controlled experiment. After a one-week observation phase to obtain baseline clinical data, participants were randomly assigned to either placebo or high-concentration HRW (> 5.5 millimoles of H2 per day) over a 24-week period. Supplementing your diet  In comparison to placebo, high-concentration HRW lowered blood cholesterol and glucose levels, decreased serum haemoglobin A1c, and enhanced indicators of inflammation and redox homeostasis (P 0.05). Furthermore, H2 caused a small decrease in BMI and waist-to-hip ratio. Our data support the notion that high-concentration HRW might be a useful therapy for lowering metabolic syndrome risk variables.

Author(S) Details

Tyler W. LeBaron
Centre of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic and Molecular Hydrogen Institute, Enoch, Utah, USA.

Ram B. Singh
Hospital and Research Institute, Moradabad, India.

Ghizal Fatima
Era Medical College, Lucknow, India.

Kumar Kartikey
Hospital and Research Institute, Moradabad, India.

Jai P. Sharma
Hospital and Research Institute, Moradabad, India.

Sergej M. Ostojic
Applied Bioenergetics Lab, Faculty of Sport and PE, University of Novi Sad, Novi Sad, Serbia and Faculty of Health Sciences, University of Pécs, Pécs, Hungary.

Anna Gvozdjakova
Comenius University Bratislava, Medical Faculty, Pharmacobiochemical Laboratory of 3rd Medical Department, Bratislava, Slovakia.

Branislav Kura
Molecular Hydrogen Institute, Enoch, Utah, USA.

Mami Noda
Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Viliam Mojto
Third Internal Clinic, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

Mohammad Arif Niaz
Center of Nutrition Research, International College of Nutrition, Moradabad, India.

Jan Slezak
Centre of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic.

View Book:- https://stm.bookpi.org/NHMMR-V9/article/view/6914

Study on the Effect of β-Cyclodextrin on Phospholipids and Cholesterol of the Milk Fat Globule Membrane | Chapter 12 | Emerging Challenges in Agriculture and Food Science Vol. 4

 Phospholipids, like cholesterol, are found on the milk globule membrane (MFGM). The goal of this study was to see how -cyclodextrin (β-CD) affected phospholipids and cholesterol in raw pasteurised milk, in order to remove cholesterol from the milk fat. Total phospholipids in β-CD treated milk reduced marginally, but the effect of the β-CD was not significant. β-CD is a highly effective oligosaccharide for eliminating cholesterol from milk, with a reduction of more than 97%, and has no effect on individual phospholipids in the milk fat globule membrane (phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, phosphatidylinositol, and phosphatidylserina).

Author(S) Details

Leocadio Alonso
Instituto de Productos Lácteos de Asturias (CSIC), 33300 Asturias, Spain and Food Agricultural Products Center and Department of Animal Science, Oklahoma State University, Stillwater 74075. Oklahoma, USA.

Paloma Cuesta
Food Agricultural Products Center and Department of Animal Science, Oklahoma State University, Stillwater 74075. Oklahoma, USA.

María V. Calvo
Instituto de Investigación en Ciencias de la Alimentación (CSIC-UAM), 28049 Madrid, Spain.

Javier Fontecha
Instituto de Investigación en Ciencias de la Alimentación (CSIC-UAM), 28049 Madrid, Spain.


View Book:- https://stm.bookpi.org/ECAFS-V4/article/view/6411

Probiotics' Role in Human Disease | Chapter 07 | Emerging Trends in Disease and Health Research Vol. 2

 It is clear that probiotics play a role in preventing or treating a variety of health problems, ranging from nutritional deficiencies to medical conditions throughout the body such as gastrointestinal diseases, diabetes, high cholesterol, obesity, and certain types of cancer. Additionally, some probiotics have benefits for healthy people, such as lowering the risk of common infectious diseases. Many probiotics have showed promise in the treatment of certain clinical disorders when abnormal microbiota have been identified. However, regulations for the use of probiotics must be established, and more study must be conducted to determine the strains and proper amount for each treatment, as well as to discover the long-term benefits and influence of probiotics when used in conjunction with drug-based treatment. The goal of this revision is to recognise the importance of probiotics in the prevention and treatment of various health disorders by compiling and comparing various research works on the topic published in recent years.

Author(S) Details

Ahmed El Salous
Facultad de Ciencias Agrarias, Universidad Agraria del Ecuador, Guayaquil, Ecuador.

View Book:- https://stm.bookpi.org/ETDHR-V2/article/view/5570

Determining the Effect of a Care Bundle for Hypertension Control on the Health Outcomes of Hypertensive Patients with Stroke Risk | Chapter 11 | Recent Developments in Medicine and Medical Research Vol. 15

 Background: Care bundles are made up of three to five evidence-based practises that must be given in a coordinated and consistent manner to improve patient health outcomes. The goal of this study was to determine the amount of stroke risk in hypertensive patients, evaluate the efficacy of a hypertension management care bundle on health outcomes in hypertensive patients with stroke risk, and identify parameters associated with the effect of care bundles on hypertensive patients. In this work, a quasi-experimental research design was adopted. The research was carried out in medical outpatient clinics of government and health insurance facilities in Port Said. A purposive sample of 105 patients was included in the study. Instruments: A structured interview was used to assess the socio-demographic characteristics and medical histories of patients, a stroke risk assessment screening tool was used to determine stroke risk among hypertensive patients, and clinical measures such as pulse, blood pressure, BMI, serum cholesterol, and fasting blood sugar were used to collect data. Results: The study found significant differences in clinical measures such as systolic blood pressure, cholesterol level, body mass index, and fasting blood sugar between hypertensive patients pre- and three months post-patient education with the care bundle for hypertension control, with P-values of 0.000, 0.000, and 0.002, respectively, between hypertensive patients pre- and three months post-patient education with the care bundle for hypertension control. Nearly two-thirds of hypertension individuals in the study group, on the other hand, were at intermediate risk of stroke, while the rest were at severe risk. Conclusion: The current study found that providing hypertensive stroke patients with a care package for hypertension control could enhance their clinical parameters significantly. The care bundle consists of a collection of interconnected evidence-based guidelines, with one guideline influencing another, such as proper foods for hypertension patients resulting in weight loss and increased physical activity. However, more research on a larger sample of hypertensive patients, both with and without a risk of stroke, is needed.

Author(S) Details

Azza Anwar Aly
Medical Surgical Nursing Department, Faculty of Nursing, Damanhour University, Egypt and Medical Surgical Nursing Department, Ibn Sina National Collegefor Medical Studies, KSA. 

Eman Saleh Shahin
Department of Medical, Surgical Nursing, Faculty of Nursing, Port-Said University, Egypt.

View Book:- https://stm.bookpi.org/RDMMR-V15/article/view/5012

The Role of Central Obesity in the Pathophysiology of Metabolic Syndrome | Chapter 21 | New Frontiers in Medicine and Medical Research Vol. 10

 Obesity (usually central), hypertension, dyslipidemia, glucose intolerance, prothrombotic condition, and inflammation are all part of the Metabolic Syndrome. MetS has been linked to the development of type 2 diabetes and heart disease. Jean Vague linked the presence of male type (android form) adiposity to the development of diabetes mellitus and cardiovascular illnesses, which are all major factors in the MetS, in the 1940s and early 1950s. The National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII), the World Health Organization (WHO), and the International Diabetes Federation all use different criteria to establish MetS. (IDF). In these classifications, central obesity is a key component of MetS. This is largely owing to the adipocyte's pivotal involvement in the syndrome's development. The contents of this article were derived from a comprehensive internet search of relevant literature, and it attempts to review the pathophysiological significance of central obesity in the development of the metabolic syndrome's components. We advocate for early diagnosis of central obesity by basic methods such as measuring the waist circumference with a measuring tape.

Author (S) Details

G. Odoh
Department of Internal medicine, Jos UniversityTeaching Hospital, Jos, Nigeria.

J. N. Uwakwe
Department of Internal medicine, Jos UniversityTeaching Hospital, Jos, Nigeria.

J. O. Edah
Department of Internal medicine, Jos UniversityTeaching Hospital, Jos, Nigeria.

J. E. Ojobi
Department of Internal Medicine, Federal Medical Center Markudi, Nigeria.

E. K. Chuhwak
Department of Internal medicine, Jos UniversityTeaching Hospital, Jos, Nigeria.

View Book :- https://stm.bookpi.org/NFMMR-V10/article/view/3541

The True Cause of Coronary Artery Disease; Cholesterol is Irrelevant | Chapter 10 | New Frontiers in Medicine and Medical Research Vol. 4

 This report is a compilation of 22 studies that concludes that free radical damage to tumour suppressor genes causes coronary artery disease. This mutation allows cells to proliferate out of control, resulting in benign mini tumours between the endothelium lining and the smooth muscle walls of arteries. These tumours generate microscopic tears in the endothelium, which are patched with interlacing fibrin filaments as they expand. Minerals (particularly calcium), heavy metals, macrophages, and cellular detritus are trapped in this tough scar tissue. The last smooth layer of cholesterol that coats this vascular plaque has little bearing on its progression. According to current national cholesterol standards, over 75 percent of patients hospitalised for a heart attack had cholesterol levels that indicated they were not at high risk for a cardiovascular event. As a result, there is no link between cholesterol levels in the blood and coronary artery disease.

Author (S) Details

David Rowland
Independent Researcher Registered with ORCID, Canada.

View Book :- https://stm.bookpi.org/NFMMR-V4/article/view/2889

The Nutritional Bypass: Restore Circulation without Surgery | Book Publisher International

 Heart disease is the leading cause of mortality in the United States, killing 655,000 people each year. Heart disease is responsible for one out of every four deaths. Every 36 seconds, one person dies as a result of this. It doesn't have to be this this. Heart attacks, strokes, and diabetic gangrene are all caused by atherosclerosis, the gradual narrowing of arteries that causes heart attacks, strokes, and diabetic gangrene. The only way to overcome any health issue is to address the root of the problem. That is impossible to achieve with drugs or surgery. Circulation is restored using bypass circulation. Temporarily restores circulation, but does little to prevent the same or other arteries from becoming clogged again in the future. Nutritional arterial cleaning provides what the bypass cannot – and much more – by treating the cause of narrowing arteries.

Author(s) Details

David Rowland
Independent Researcher, Canada.

View Book:- https://stm.bookpi.org/TNBRCS/article/view/2744

Effect of β-Cyclodextrin on Cholesterol Reduction in Egg and Duck Liver Pâté | Chapter 11 | Current Research in Agricultural and Food Science Vol. 5

 Because of its affinity for non-polar molecules like cholesterol, the use of -cyclodextrin (-CD) to lower cholesterol is becoming more common in food research. The goal of this study was to see if -CD could remove cholesterol from natural egg, powdered egg, and duck liver pâté, as well as what effect it had on particular fatty acids. A concentration of 5% -CD was shown to be enough for removing 80.04 4.96–82.12 5.36 percent cholesterol from yolks and powdered eggs, as well as 80.21 5.28 percent cholesterol from duck liver pâté. Centrifugation was used to separate the -CD complexed to cholesterol. Individual fatty acid compositions did not differ significantly (p 0.05) between controls and products treated with 5%-CD. This research can be used to design low-cholesterol functional diets for hypercholesterolemia patients.

Author(s) Details

Leocadio Alonso
Instituto de Productos Lácteos de Asturias (CSIC), 33300 Asturias, Spain.

María V. Calvo
Instituto de Investigación en Ciencias de la Alimentación (CSIC-UAM), 28049 Madrid, Spain.

Javier Fontecha
Instituto de Investigación en Ciencias de la Alimentación (CSIC-UAM), 28049 Madrid, Spain.

View Book :- https://stm.bookpi.org/CRAFS-V5/article/view/1141