The Role of Central Obesity in the Pathophysiology of Metabolic Syndrome | Chapter 21 | New Frontiers in Medicine and Medical Research Vol. 10

 Obesity (usually central), hypertension, dyslipidemia, glucose intolerance, prothrombotic condition, and inflammation are all part of the Metabolic Syndrome. MetS has been linked to the development of type 2 diabetes and heart disease. Jean Vague linked the presence of male type (android form) adiposity to the development of diabetes mellitus and cardiovascular illnesses, which are all major factors in the MetS, in the 1940s and early 1950s. The National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII), the World Health Organization (WHO), and the International Diabetes Federation all use different criteria to establish MetS. (IDF). In these classifications, central obesity is a key component of MetS. This is largely owing to the adipocyte's pivotal involvement in the syndrome's development. The contents of this article were derived from a comprehensive internet search of relevant literature, and it attempts to review the pathophysiological significance of central obesity in the development of the metabolic syndrome's components. We advocate for early diagnosis of central obesity by basic methods such as measuring the waist circumference with a measuring tape.

Author (S) Details

G. Odoh
Department of Internal medicine, Jos UniversityTeaching Hospital, Jos, Nigeria.

J. N. Uwakwe
Department of Internal medicine, Jos UniversityTeaching Hospital, Jos, Nigeria.

J. O. Edah
Department of Internal medicine, Jos UniversityTeaching Hospital, Jos, Nigeria.

J. E. Ojobi
Department of Internal Medicine, Federal Medical Center Markudi, Nigeria.

E. K. Chuhwak
Department of Internal medicine, Jos UniversityTeaching Hospital, Jos, Nigeria.

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