The Influence of High-Concentration Hydrogen-Rich Water for 24-Week on Body Composition, Blood Lipid Profiles, and Inflammatory Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial | Chapter 1 | Current Topics on Chemistry and Biochemistry Vol. 4

 

 The epidemic of metabolic syndrome has spread to every country. Obesity, hyperglycemia, and dyslipidemia are linked to it. The aftereffects of this disorder raise mortality rates and the risk of cardiovascular and neurological conditions. In addition to disrupting cellular homeostasis, the pathogenesis of metabolic syndrome is linked to dysregulation of redox and inflammatory state. It has been demonstrated that molecular hydrogen (H2) lowers oxidative stress, enhances cellular performance, and lowers chronic inflammation. Although H2-rich water (HRW) has been demonstrated in pre-clinical and clinical research to have positive effects on some aspects of the metabolic syndrome, it is unknown how long-term, high-concentration HRW would affect metabolic syndrome. 60 individuals with metabolic syndrome took part in a randomised, double-blinded, placebo-controlled  Following a one-week initial observation period during which baseline clinical data were collected, participants were randomly assigned to receive either a placebo or high-concentration HRW (> 5.5 millimoles of H2 per day) for 24 weeks. In comparison to placebo, high-concentration HRW supplementation substantially decreased blood cholesterol and glucose levels, attenuated serum haemoglobin A1c, and enhanced inflammatory and redox homeostasis indicators (P 0.05). H2 also caused a considerable drop in blood pressure as well as a modest decrease in waist-to-hip ratio and body mass index. These findings support earlier research showing high-concentration HRW may have therapeutic effects in reducing risk factors for metabolic syndrome and its associated complications.

Author(s) Details:

Tyler W. Le Baron,
Centre of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic and  Molecular Hydrogen Institute, Enoch, Utah, USA.

Ram B. Singh,
Hospital and Research Institute, Moradabad, India.

Ghizal Fatima,
Era Medical College, Lucknow, India.

Kumar Kartikey,
Hospital and Research Institute, Moradabad, India.

Jai P. Sharma,
Hospital and Research Institute, Moradabad, India.

Sergej M. Ostojic,
Applied Bioenergetics Lab, Faculty of Sport and PE, University of Novi Sad, Novi Sad, Serbia and  Faculty of Health Sciences, University of Pecs, Pecs, Hungary.

Anna Gvozdjakova,
Pharmacobiochemical Laboratory of 3rd Medical Department, Medical Faculty, Comenius University Bratislava, Bratislava, Slovakia.

Branislav Kura,
Molecular Hydrogen Institute, Enoch, Utah, USA.

Mami Noda,
Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Viliam Mojto,
Third Internal Clinic, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

Mohammad Arif Niaz,
Center of Nutrition Research, International College of Nutrition, Moradabad, India.

Jan Slezak,
Centre of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic.

Please see the link here: https://stm.bookpi.org/CTCB-V4/article/view/7804