Study about Encapsulation of Vitamin C into β‐Cyclodextrin: An Approach towards Advancement and Regulatory Release | Chapter 9 | Research Aspects in Biological Science Vol. 7

 By using dependable spectroscopic, physicochemical, and calorimetric approaches, the host-guest inclusion complexes of -cyclodextrin with two vitamins, nicotinic acid and ascorbic acid, in aqueous medium, have been investigated as a stabiliser, carrier, and regulatory releaser of the guest molecules. To demonstrate the host-guest assembly's 1:1 stoichiometry, job plots were created using UV-visible spectroscopy. The stereo-chemical structure of the inclusion complexes has been revealed using 2D NMR spectroscopy. The inclusion procedure is further strengthened by studies on conductivity and surface tension. Association constants for the vitamin-CD inclusion complexes have been determined using the van't Hoff equation and UV-visible spectroscopy. Then, using the Benesi-Hildebrand technique and a non-linear programme, thermodynamic parameters have been derived. Isothermal titration is used to measure the stoichiometry, association constant, and thermodynamic properties with accuracy. Isothermal titration calorimetric studies have been conducted in order to precisely quantify the stoichiometry, association constant, and thermodynamic properties. The results show a decrease in SO, which is offset by a greater negative value of HO, making the inclusion process as a whole thermodynamically advantageous. Based on their chemical structures, it has been determined that ascorbic acid has a greater association constant than nicotinic acid.

Author(s) Details:

Subhadeep Saha,
Department of Chemistry, University of North Bengal, Darjeeling-734013, India.

Sanjoy Barman,
Department of Chemistry, University of North Bengal, Darjeeling-734013, India.

Debadrita Roy,
Department of Chemistry, University of North Bengal, Darjeeling-734013, India.

Anupam Dutta,
Department of Chemistry, Alipurduar University, Alipurduar-736122, India.

Debabrata Biswas,
Department of Chemistry, Alipurduar University, Alipurduar-736122, India.

Kanak Roy,
Department of Chemistry, Alipurduar University, Alipurduar-736122, India.

Vikas Kumar Dakua,
Department of Chemistry, Alipurduar University, Alipurduar-736122, India.

Shatarupa Basak,
Department of Chemistry, University of North Bengal, Darjeeling-734013, India.

Koushik Baul,
Department of Chemistry, University of North Bengal, Darjeeling-734013, India.

Mahendra Nath Roy,
Department of Chemistry, University of North Bengal, Darjeeling-734013, India.

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