Design, Discovery and Optimization of Novel Molecular Hybrids N-1 Substituted Indolyl Chalcone of N-1 Substituted 2-Acetyl Benzimidazole as Potent Tubulin Inhibitor Agent| Chapter 5 | Challenges and Advances in Pharmaceutical Research Vol. 6

 One of the widely employed rational drug design techniques to create new ligands is molecular hybridization. The molecular hybridization technique increases the biological activity of the newly synthesised pharmacophores while attenuating the detrimental effects brought on by the individual components. Thirty different forms of N-1 substituted indolyl chalcone of N-1 substituted 2-Acetyl Benzimidazole were provisionally docked to three tubulin colchicine receptors, which are supposedly the targets for anticancer therapy. A new scaffold with the potential to be a potent tubulin inhibitor was demonstrated when it was coupled. Clinical research has a pressing need for the discovery and development of new tubulin polymerization inhibitors.  

Author(s) Details:

Anjali Wanegaonkar,
Bharati Vidyapeeth College of Pharmacy, Mumbai University, Sector-8, CBD Belapur New Mumbai- 400 614, Maharashtra, India.

Deepali Jagdale,
Bharati Vidyapeeth College of Pharmacy, Mumbai University, Sector-8, CBD Belapur New Mumbai- 400 614, Maharashtra, India.

Milind J. Bhitre,
Department Pharmaceutical Chemistry C. U. Shah College of Pharmacy, S. N. D. T. Women’s University, Sir Vithaldas Vidyavihar, Juhu Road, Santacruz (West), Mumbai- 400 049, Maharashtra,India.

Please see the link here: https://stm.bookpi.org/CAPR-V6/article/view/8093