Anti-inflammatory and Antioxidant Effects of HV Prostate Capsule (HVPC) in Rats with Induced Benign Prostatic Hyperplasia | Chapter 9 | Current Practice in Medical Science Vol. 11

 The anti-inflammatory and antioxidant actions of HV prostate capsules (HVPCs), a Vietnamese herbal prescription medicine used to treat benign prostatic hyperplasia (BPH), are not entirely understood. In white rats with induced BPH, this study investigated the anti-inflammatory and antioxidant properties of HVPC. In a rat model of BPH, the antioxidant and anti-inflammatory properties of HVPC were examined. Using an enzyme-linked immunosorbent assay (ELISA) kit, the inflammatory cytokines interleukin-8 (IL-8) and tumour necrosis factor (TNF-) were assessed in serum and prostate tissue. Superoxide dismutase (SOD) activity and levels of malondialdehyde (MDA) in the blood and prostate gland were used to assess the antioxidant impact of HVPC. In a rat model of BPH, HVPCs at doses of 700 mg/kg/day and 1400 mg/kg/day had positive anti-inflammatory effects and decreased the inflammatory cytokines IL-8 and TNF- in serum and prostate tissue. By raising serum SOD activity and lowering MDA levels in blood and prostate tissue, this capsule also demonstrated antioxidant properties on rats with BPH. HVPC was discovered to improve prostate histology and decrease absolute and relative prostatic weight. HVPC decreased ductal cell growth, compression of the gland parenchyma, and inflammation of the prostate gland.

Author(s) Details:

Ngoc Bich Son Le,
Tri Duc Thanh General Hospital, Thanh Phu, Dinh Tuong, Yen Đinh, Thanh Hoa province-40000, Vietnam.

Thi Thanh Nhan Le,
Tri Duc Thanh General Hospital, Thanh Phu, Dinh Tuong, Yen Đinh, Thanh Hoa province-40000, Vietnam.

Van Hung Nguyen,
Danang Traditional Medicine Hospital, 9 Tran Thu Đo, Khue Trung, Cam Le, Da Nang City-50000, Vietnam.

Tu Bui,
Danang Traditional Medicine Hospital, 9 Tran Thu Đo, Khue Trung, Cam Le, Da Nang City-50000, Vietnam.

Thao Phuong Thi Nguyen,
Thai Nguyen University of Medicine and Pharmacy, 284 Luong Ngoc Quyen Street, Thai Nguyen City-24000, Vietnam.

Hoang Ngan Nguyen,
Department of Pharmacology, Vietnam Military Medical University, 160 Phung Hung, Phuc La, Ha Dong, Hanoi-100000, Vietnam.

Viet Van Chau,
Thai Nguyen University of Medicine and Pharmacy, 284 Luong Ngoc Quyen Street, Thai Nguyen City-24000, Vietnam.

Dao Cuong To,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong District, Hanoi-12116, Vietnam and Phenikaa Research and Technology Institute (PRATI), A&A Green Phoenix Group JSC, 167 Hoang Ngan, Cau Giay, Hanoi-11313, Vietnam.

Please see the link here: https://stm.bookpi.org/CPMS-V11/article/view/8033