Anti-inflammatory and Antioxidant Effects of HV Prostate Capsule (HVPC) in Rats with Induced Benign Prostatic Hyperplasia | Chapter 9 | Current Practice in Medical Science Vol. 11

 The anti-inflammatory and antioxidant actions of HV prostate capsules (HVPCs), a Vietnamese herbal prescription medicine used to treat benign prostatic hyperplasia (BPH), are not entirely understood. In white rats with induced BPH, this study investigated the anti-inflammatory and antioxidant properties of HVPC. In a rat model of BPH, the antioxidant and anti-inflammatory properties of HVPC were examined. Using an enzyme-linked immunosorbent assay (ELISA) kit, the inflammatory cytokines interleukin-8 (IL-8) and tumour necrosis factor (TNF-) were assessed in serum and prostate tissue. Superoxide dismutase (SOD) activity and levels of malondialdehyde (MDA) in the blood and prostate gland were used to assess the antioxidant impact of HVPC. In a rat model of BPH, HVPCs at doses of 700 mg/kg/day and 1400 mg/kg/day had positive anti-inflammatory effects and decreased the inflammatory cytokines IL-8 and TNF- in serum and prostate tissue. By raising serum SOD activity and lowering MDA levels in blood and prostate tissue, this capsule also demonstrated antioxidant properties on rats with BPH. HVPC was discovered to improve prostate histology and decrease absolute and relative prostatic weight. HVPC decreased ductal cell growth, compression of the gland parenchyma, and inflammation of the prostate gland.

Author(s) Details:

Ngoc Bich Son Le,
Tri Duc Thanh General Hospital, Thanh Phu, Dinh Tuong, Yen Đinh, Thanh Hoa province-40000, Vietnam.

Thi Thanh Nhan Le,
Tri Duc Thanh General Hospital, Thanh Phu, Dinh Tuong, Yen Đinh, Thanh Hoa province-40000, Vietnam.

Van Hung Nguyen,
Danang Traditional Medicine Hospital, 9 Tran Thu Đo, Khue Trung, Cam Le, Da Nang City-50000, Vietnam.

Tu Bui,
Danang Traditional Medicine Hospital, 9 Tran Thu Đo, Khue Trung, Cam Le, Da Nang City-50000, Vietnam.

Thao Phuong Thi Nguyen,
Thai Nguyen University of Medicine and Pharmacy, 284 Luong Ngoc Quyen Street, Thai Nguyen City-24000, Vietnam.

Hoang Ngan Nguyen,
Department of Pharmacology, Vietnam Military Medical University, 160 Phung Hung, Phuc La, Ha Dong, Hanoi-100000, Vietnam.

Viet Van Chau,
Thai Nguyen University of Medicine and Pharmacy, 284 Luong Ngoc Quyen Street, Thai Nguyen City-24000, Vietnam.

Dao Cuong To,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong District, Hanoi-12116, Vietnam and Phenikaa Research and Technology Institute (PRATI), A&A Green Phoenix Group JSC, 167 Hoang Ngan, Cau Giay, Hanoi-11313, Vietnam.

Please see the link here: https://stm.bookpi.org/CPMS-V11/article/view/8033

Effects of CTHepaB, a Traditional Vietnamese Medicinal Formulation, on the Treatment of Cirrhosis in Wistar Rats | Chapter 11 | Technological Innovation in Pharmaceutical Research Vol. 2

 Objectives: CTHepaB is a popular Vietnamese herbal formulation that is used to avoid liver problems. In this analysis, the effects of CTHepaB on cirrhosis in Wistar rats caused by carbon tetrachloride (CCl4) combined with alcohol, high-fat, and iron diet were evaluated in vivo.

Materials and Methods : Cirrhosis was induced in Wistar rats by injecting CC14 (5.0 ml/kg) subcutaneously once a week for 10 weeks. The rats were then given a diet that included 20% fat, 0.05 percent cholesterol, and iron oxalate. Every day, rats were given plain water, and on one day, they were given water laced with 30% ethanol. The rats were divided into five groups and given distilled water, CC14, silymarin (70 mg/kg/24 h), or CTHepaB (at 0.56 and 1.12 g/kg/24 h) for four weeks, during which blood samples were taken for biochemical studies, the livers were dissected to assess weight and morphology, and 4-hydroxyproline was quantified to assess fibrosis and collagen accumulation.

Results : CTHepaB reduced the activity of the enzymes aspartate transaminase (AST) and alanine transaminase (ALT) in the blood in cirrhotic Wistar rats at both 0.56 and 1.12 g/kg/24 h (p 0.01), increased plasma albumin levels, and decreased prothrombin times (p 0.05). According to Masson's trichrome-stained templates, CTHepaB treatment strengthened the rats' physical condition, decreased hydroxyproline concentrations in the liver, and minimised the level of cirrhosis. CTHepaB had dose-dependent effects, with a dose of 70 mg/kg/24 h being equivalent to silymarin.

Conclusion: CTHepaB was effective for the treatment of a cirrhosis model in Wistar rats.

Author (s) Details

Dau Xuan Canh
Vietnam University of Traditional Medicine, 2 Tran Phu, Mo Lao Ward, Ha Dong district, Hanoi, Viet Nam. 

Le Thi Tuyet
Vietnam University of Traditional Medicine, 2 Tran Phu, Mo Lao Ward, Ha Dong district, Hanoi, Viet Nam. 

Manh Hung Tran
Faculty of Pharmacy, Dong A University, 33 Xo Viet Nghe Tinh, Hoa Cuong Nam ward, Hai Chau District, Da Nang City 550000, Vietnam.

Nguyen Hoang Ngan
Vietnam Military Medical University, 160 Phung Hung, Phuc La ward, Ha Dong district, Hanoi, Viet Nam.

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