As a psychotic illness, schizophrenia is treated with a variety of antipsychotic drugs. The Alzheimer's drug donepezil, which improves cognition, has just received approval. Therefore, we made an effort to assess its importance for the mice models of methylphenidate-induced psychosis.
Swiss albino mice (n=6) were given 5 mg/kg of methylphenidate intraperitoneally to cause psychosis (i.p). groups were compared using haloperidol at a dose of 0.2 mg/kg after receiving donepezil at a dose of 1 mg/kg both alone and in conjunction with 0.1 mg/kg of the drug. The haloperidol-induced catalepsy test was also employed to gauge donepezil's effectiveness. ANOVA and the Bonferroni's test were both employed for statistical analysis.
Like amphetamine, methylphenidate effectively generated stereotypical behaviour in mice. There was no statistically significant difference between donapezil 1 mg/kg and haloperidol 0.2 mg/kg in their ability to significantly diminish stereotypy behaviour (p 0.05). The effects of donepezil were only slightly less potent than those of standard, and when combined with haloperidol (1 mg/kg with 0.1 mg/kg), they were on par with those of standard haloperidol. Donepezil showed a statistically insignificantly reduced (p>0.05) but slightly increased tendency to cause catatonia. Methylphenidate successfully induces psychosis in animals, and donepezil looks to show potential as an antipsychotic supplementary therapy.Author(s) Details:
Hemant Tanwani,
Department of Pharmacology, MGM Medical College, Indore, Madhya Pradesh, India.
Ritesh Churihar,
Department of Pharmacology, Government Medical College, Ratlam, Madhya Pradesh, India.
Sameer Pandit,
Department of Pharmacology, R. D. Gardi Medical College, Ujjain, Madhya Pradesh, India.
Please see the link here: https://stm.bookpi.org/CAPR-V6/article/view/8095
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