Study of IDH1 (R132H) Mutation and Expression of ATRX Marker in Correlation with the Histopathological Grading in Gliomas| Chapter 8 | Challenges and Advances in Pharmaceutical Research Vol. 6

 Background: Primary malignant brain tumours are the third leading cause of cancer-related death and morbidity globally. IDH1 mutation has also been shown to be a predictive factor in more recent WHO classifications of CNS tumours. In gliomas, the presence of an IDH1 change increases progression-free survival. Similar to this, improved outcomes in astrocytic malignancies are linked to ATRX mutations. The goal of the current study is to evaluate the relationship between IDH1 mutation, ATRX expression, and histopathological grading in glial tumours, which will enable us grade glial tumours more accurately in light of recent molecular developments.

The main goal is to comprehend how the histopathological grades of glial tumours correlate with the expression of IDH1 and ATRX on immunohistochemistry. The current study will be conducted over a two-year period in the Histopathology and Immunohistochemistry division of the Pathology Department at Jawaharlal Nehru Medical College in Sawangi (Meghe), in coordination with the Department of Neurosurgery at Acharya Vinoba Bhave Rural Hospital in Sawangi (Meghe). About 45 to 50 resected samples from suspected instances of glial tumours received at the J.N.M.C.'s Department of General Pathology will be used in this investigation. In order to gain a better understanding, we will compare the link between IDH1 mutation and ATRX expression with the histopathological grades in glial tumours and current molecular developments on immunohistochemistry using a well-tabulated master chart. Results: A master chart with properly tabulated data will show the observations. Conclusion: Based on the research's findings, a conclusion will be drawn.

Author(s) Details:

Pooja Jha,
Jawaharlal Nehru Medical College (DMIMS), Sawangi (M), Wardha, India.

Samarth Shukla,
Department of Pathology, Jawaharlal Nehru Medical College (DMIMS), Sawangi (M), Wardha, India.

Sunita Vagha,
Department of Pathology, Jawaharlal Nehru Medical College (DMIMS), Sawangi (M), Wardha, India.

Ravindra P. Kadu,
Department of Pathology, Jawaharlal Nehru Medical College (DMIMS), Sawangi (M), Wardha, India.

Sourya Acharya,
Department of Medicine, Jawaharlal Nehru Medical College (DMIMS), Sawangi (M), Wardha, India.

Please see the link here: https://stm.bookpi.org/CAPR-V6/article/view/8096