Solid Lipid Nanoparticles: Preparation, Characterization and Applications- A Look Back| Chapter 3 | Challenges and Advances in Pharmaceutical Research Vol. 6

 There are several potential uses for Solid Lipid Nanoparticles (SLN) in the quickly growing field of nanotechnology, including drug delivery, research and clinical medicine, as well as other other science and technological fields. It's common for active pharmacological compounds still in development to have poor water solubility and bioavailability. The distinct size-dependent properties of SLN may be leveraged to create innovative therapeutics. The limits of conventional pharmaceutical delivery technologies are something that nanotechnology hopes to fix. Intriguing solid lipid nanoparticles have medicinal promise. Their main benefit is that they are prepared with lipids that the body can tolerate. Solid Lipid Nanoparticles are nano-carriers with sizes between 10 and 1000 nanometers. SLNs were developed in an effort to address the drawbacks of polymeric nanoparticles. By switching out polymers formed from lipid nanoparticles for lipids, a new formulation technique was established. The use of SLN for drug delivery is studied in terms of potential benefits and drawbacks, as well as preparation techniques and the underlying drug release principle. Additionally described and used in medication delivery are SLNs. In the form of "solid" or "liquid" lipids, nanometer-sized lipid particles are dispersed in water or a surfactant solution (SLNs). Drugs that are lipophilic or hydrophilic can now be given thanks to SLN technology. The usage of SLNs may enhance the bioavailability of drugs. An innovative way for delivering medications to various levels of a patient's body is to combine medications with nanocarriers. As a result of its potential for controlled and precise medication delivery, solid lipid nanoparticles have caught the attention of researchers.

Author(s) Details:

M. Swamivelmanickam,
Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar-608002, Tamilnadu, India.

S. Sivakrishnan,
Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar-608002, Tamilnadu, India.

R. Suresh,
Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar-608002, Tamilnadu, India.

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