Formulation and Evaluation of Solid Lipid Nanoparticles-based Gel Containing Miconazole Nitrate (An Antifungal Agent) | Chapter 7 | Advanced Concepts in Pharmaceutical Research Vol. 5

Solid lipid nanoparticles are the advanced drug delivery system in which the active ingredient is incorporated into a lipid carrier (e.g. Triglycerides, fatty acid, steroids, partial glycerides, and waxes) and it is stabilized by using a biocompatible surfactant such as poloxamer, polysorbate, lecithin. The objective of the present investigation was to prepare and evaluate the solid lipid nanoparticle (SLN) based gel using an antifungal agent Miconazole nitrate (MN). Miconazole nitrate was received from Micro Labs Limited, Hosur, HPMC and Carbopol 940, stearic acid, tween 80, glycerol was kindly provided by East Point College of Pharmacy. Compatibility of drug and excipients was confirmed by IR studies. The formulation was prepared by Microemulsion and homogenization method using stearic acid and tween 80.

All the Solid lipid nanoparticle formulations were subjected to particle size, drug entrapment efficiency, scanning electron microscopy and Differential Scanning Calorimetry. Formulation F2 resulted in the least SLN particle size. The F3-SLN dispersion showed a higher entrapment efficiency of 78.7%. Scanning Electron Microscopy of prepared SLN particles showed that prepared particles were spherical and the surface was rough. The Differential Scanning Calorimetry of the SLN particles showed the conversion of the drug from a crystalline to an amorphous state. The prepared SLN particles were dispersed in HPMC Carbopol gel. The resulting SLN-loaded gels were evaluated for appearance, spreadability and in vitro drug release. The SLN-loaded gels showed good appearance and spreadability. The in vitro drug release of SLN gel was evaluated using a Franz diffusion cell using dialysis membrane 70 with phosphate buffer pH 7.4 as a dissolution media. All the formulations showed drug release till 24hrs. It was concluded that Miconazole nitrate-loaded SLN gel formulation containing Carbopol 940 in combination with Hydroxy Propyl Methyl Cellulose was suitable for topical application since it showed prolonged drug release.

Author(s) Details:

V. Chandrakala,
Department of Pharmaceutics, East Point College of Pharmacy, Bidrahalli, Bangalore, India.

H. S. Mamatha,
Department of Pharmaceutics, East Point College of Pharmacy, Bidrahalli, Bangalore, India.

A. Usha,
Department of Pharmaceutics, East Point College of Pharmacy, Bidrahalli, Bangalore, India.

Banu Priya,
Department of Pharmaceutics, East Point College of Pharmacy, Bidrahalli, Bangalore, India.

Please see the link here: https://stm.bookpi.org/ACPR-V5/article/view/13283

Solid Lipid Nanoparticles: Preparation, Characterization and Applications- A Look Back| Chapter 3 | Challenges and Advances in Pharmaceutical Research Vol. 6

 There are several potential uses for Solid Lipid Nanoparticles (SLN) in the quickly growing field of nanotechnology, including drug delivery, research and clinical medicine, as well as other other science and technological fields. It's common for active pharmacological compounds still in development to have poor water solubility and bioavailability. The distinct size-dependent properties of SLN may be leveraged to create innovative therapeutics. The limits of conventional pharmaceutical delivery technologies are something that nanotechnology hopes to fix. Intriguing solid lipid nanoparticles have medicinal promise. Their main benefit is that they are prepared with lipids that the body can tolerate. Solid Lipid Nanoparticles are nano-carriers with sizes between 10 and 1000 nanometers. SLNs were developed in an effort to address the drawbacks of polymeric nanoparticles. By switching out polymers formed from lipid nanoparticles for lipids, a new formulation technique was established. The use of SLN for drug delivery is studied in terms of potential benefits and drawbacks, as well as preparation techniques and the underlying drug release principle. Additionally described and used in medication delivery are SLNs. In the form of "solid" or "liquid" lipids, nanometer-sized lipid particles are dispersed in water or a surfactant solution (SLNs). Drugs that are lipophilic or hydrophilic can now be given thanks to SLN technology. The usage of SLNs may enhance the bioavailability of drugs. An innovative way for delivering medications to various levels of a patient's body is to combine medications with nanocarriers. As a result of its potential for controlled and precise medication delivery, solid lipid nanoparticles have caught the attention of researchers.

Author(s) Details:

M. Swamivelmanickam,
Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar-608002, Tamilnadu, India.

S. Sivakrishnan,
Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar-608002, Tamilnadu, India.

R. Suresh,
Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar-608002, Tamilnadu, India.

Please see the link here: https://stm.bookpi.org/CAPR-V6/article/view/8091