Solid lipid nanoparticles are the advanced drug delivery
system in which the active ingredient is incorporated into a lipid carrier
(e.g. Triglycerides, fatty acid, steroids, partial glycerides, and waxes) and
it is stabilized by using a biocompatible surfactant such as poloxamer,
polysorbate, lecithin. The objective of the present investigation was to
prepare and evaluate the solid lipid nanoparticle (SLN) based gel using an
antifungal agent Miconazole nitrate (MN). Miconazole nitrate was received from
Micro Labs Limited, Hosur, HPMC and Carbopol 940, stearic acid, tween 80,
glycerol was kindly provided by East Point College of Pharmacy. Compatibility
of drug and excipients was confirmed by IR studies. The formulation was
prepared by Microemulsion and homogenization method using stearic acid and
tween 80.
All the Solid lipid nanoparticle formulations were subjected to particle size,
drug entrapment efficiency, scanning electron microscopy and Differential
Scanning Calorimetry. Formulation F2 resulted in the least SLN particle size.
The F3-SLN dispersion showed a higher entrapment efficiency of 78.7%. Scanning
Electron Microscopy of prepared SLN particles showed that prepared particles
were spherical and the surface was rough. The Differential Scanning Calorimetry
of the SLN particles showed the conversion of the drug from a crystalline to an
amorphous state. The prepared SLN particles were dispersed in HPMC Carbopol
gel. The resulting SLN-loaded gels were evaluated for appearance, spreadability
and in vitro drug release. The SLN-loaded gels showed good appearance and
spreadability. The in vitro drug release of SLN gel was evaluated using a Franz
diffusion cell using dialysis membrane 70 with phosphate buffer pH 7.4 as a
dissolution media. All the formulations showed drug release till 24hrs. It was
concluded that Miconazole nitrate-loaded SLN gel formulation containing
Carbopol 940 in combination with Hydroxy Propyl Methyl Cellulose was suitable
for topical application since it showed prolonged drug release.
Author(s) Details:
V. Chandrakala,
Department of Pharmaceutics, East Point College of Pharmacy,
Bidrahalli, Bangalore, India.
H.
S. Mamatha,
Department
of Pharmaceutics, East Point College of Pharmacy, Bidrahalli, Bangalore, India.
A. Usha,
Department of Pharmaceutics, East Point College of Pharmacy,
Bidrahalli, Bangalore, India.
Banu Priya,
Department of Pharmaceutics, East Point College of Pharmacy,
Bidrahalli, Bangalore, India.
Please see the link here: https://stm.bookpi.org/ACPR-V5/article/view/13283
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