Background: Within the landscape of rising skin disorders, a
substantial portion is rooted in autoimmune etiology, often showcasing
manifestations of systemic pathologies. This chapter explores the intricate
association between autoimmune thyroid disorders and Vitiligo, a skin condition
marked by progressive melanocyte loss.
Emphasis is placed on elucidating the prevalence of thyroid
autoantibodies in vitiligo patients, specifically Anti-thyroid peroxidase
(anti-TPO Ab) and antithyroglobulin (anti-TG Ab) Antibodies.
Research Methodology: A comprehensive hospital-based case-control study
encompassing 60 participants was conducted to unravel the complex relationship
between thyroid autoimmunity and dermatological disorders, such as psoriasis,
melasma, atopic dermatitis, and Vitiligo.
Noteworthy findings indicate a robust association between autoimmune
thyroid disorders and Vitiligo, with elevated thyroid Antibody levels observed
in vitiligo cases compared to controls.
Key Results: The prevalence of autoimmune thyroid disease in vitiligo patients
surpasses that of the general population, underscoring the imperative for
systematic screening and heightened awareness.
In-depth biochemical analyses unveil significant disparities in thyroid
hormone profiles and Antibody levels between vitiligo cases and controls,
hinting at a potential role of thyroid dysfunction in the etiopathogenesis of
Vitiligo.
Conclusion and Implications: This chapter contributes substantively to the
burgeoning body of evidence supporting the nexus between autoimmune thyroid
disorders and Vitiligo. Exploring
underlying mechanisms and shared genetic factors is a foundation for informed
clinical practices. The insights from
this study pave the way for enhanced patient care and the development of
tailored treatment strategies for those navigating the complexities of
coexisting autoimmune conditions. The
imperative of early detection and management of thyroid autoimmunity in
vitiligo patients is emphasized, offering practical guidance to healthcare
professionals engaged in the nuanced care of individuals grappling with
autoimmune skin disorders.
Author(s) Details:
Praveen Prashant,
Department of Biochemistry, Pt BD Sharma PGIMS Rohtak, Haryana, India.
Usha Kataria,
Department of Dermatology, Venereology and Leprology, BPS GMC for Women Khanpur Kalan, Sonepat, Haryana, India.
Sonia Vashist,
Department of Dermatology, Venereology and Leprology, Tripti Hospital, Rohtak, Haryana, India.
Piyush Bansal,
Department of Biochemistry, BPS GMC for Women Khanpur Kalan, Sonepat, Haryana, India.
Abhishek Bansal,
Department of Biochemistry, Pt BD Sharma PGIMS Rohtak, Haryana, India.
Please see the link here: https://stm.bookpi.org/RUDHR-V1/article/view/13216
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