Association of IL-17A Gene Polymorphism and Its Influence on Serum IL-17A & IL-6 Levels in Diabetes with Chronic Periodontitis Patients | Book Publisher International

Interleukin-6 (IL-6) is an important cytokine which involved in the regulation of host immune response in systemic and periodontal infection. Interleukin-17 (IL-17) is a proinflammatory cytokine secreted by Th-17 cells and activate neutrophils which lead to chemokine expression. IL-17& IL-6 cytokines are reported to be associated with inflammatory conditions like rheumatoid arthritis, airway mucin secretion, asthma and type 1 & 2 diabetes mellitus and periodontitis.This study was done to find out whether there is any association between IL-17A & 6 cytokines and IL-17A gene polymorphism (Alleles) of chronic periodontitis in type 1 & 2 diabetes patients.This study was done on 359 subjects, and consists of 6 groups and these are group 1 which included of 28 patients from type I diabetes with periodontitis. The group-2 was patients from type 1 diabetes and without chronic periodontitis, there were 71 type 2 diabetic patients with chronic periodontitis in group 3 while 76 patients were included in group 4 and they had only type 2 diabetes. In the same way, there were total of 78 non diabetic patients in the group-5 with only chronic periodontitis. The last group 6 consists of nondiabetic patients and the sample size for this group was 78 patients and no one has periodontitis. The study showed that IL-17A polymorphism is significantly more associated with type 1 diabetes patients with chronic periodontitis (group-1). Individuals carrying the positive IL-17A genotype have greater risk for T1DM with periodontitis. IL-17A & 6 cytokines level used to identify the severity of the periodontal destruction with diabetes mellitus and It can consider as biomarker for disease activity.

Author(s) Details:

P. K. Sasikumar,
Department of Periodontics, JKKN Dental College and Hospital, JKKN Allied Health Sciences, Tamil Nadu, India.

Sheeja S. Varghese,
Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Chennai, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/AIGPIISIILDCPP/article/view/13257