Antifungal activity of the bioactive compound
2H-Furo[2,3-H]-1-benzopyran-2-one isolated from seeds of Psoralea corylifolia
L. recorded complete inhibition of Drechslera halodes and Trichoderma viride at
800 ppm concentration. Cladosporium cladosporoides recorded 98.0% inhibition at
1000 ppm, Curvularia lunata recorded 71.0% inhibition at 800ppm and Alternaria
alternata recorded 90.0% inhibition at 900ppm concentration respectively. The
Minimum Inhibitory Concentration (MIC) of all the test fungi was identified and
all the results obtained were compared to synthetic fungicide Dithane M45 and
Bavistin.
Background and Objective: Nature has been a source of medicinal agents for
thousands of years and an impressive number of modern drugs have been isolated
from natural sources, many based on their use in traditional medicine. The use
of traditional plant extracts as well as other alternative forms of medical
treatments have been getting momentum since the 1990s. Currently, medicinal
plants are widely used as home remedies or as alternative treatments by both
rural and urban inhabitants in developing countries. Plants generally produce
many secondary metabolites which constitute an important source of
microbicides, pesticides and many pharmaceutical drugs. Plant products still
remain the principal source of pharmaceutical agents used in traditional
medicine. Evidence has accumulated to demonstrate the promising potential of
medicinal plants used in various traditional, complementary and alternate
systems of treatment of human diseases. Synthetic chemical fungicides form a
major part of the chemical pesticides used in modern agriculture to manage
diseases both in field and during storage. The ill effects associated with the
use of chemical fungicides like carcinogenicity, teratogenicity a health
hazards necessitated the search for alternative strategies for the management
of pre and post harvest crop diseases. The objective of this study is to
exploit the Psoralea Corylifolia L. a important medicinal plants which has been
filled with many bioactive compounds and to test its potency for antifungal
activity against important seed borne pathogens
Materials and Methods: Standard procedure was adopted for the Isolation of the
Bioactive compound its antifungal activity by poisoned food technique.
Conclusion: 2H-Furo[2,3-H]-1-benzopyran-2-one, isolated from P. corylifolia
seeds, effectively controls soil-borne fungi, outperforming synthetic
fungicides at lower concentrations, making it suitable for ecologically safe
biological assays.
Author(s) Details:
Kiran B.,
PG Department of Microbiology, School of Life Sciences, Pooja Bhagavat Memorial Mahajana P.G. Centre, K.R.S. Road, Metagalli Mysore – 570016, Karnataka State, India.
Lalitha V.,
Department of Studies in Botany, Maharani’s Science College for Women, JLB Road, Mysore-570005 Karnataka State, India.
Please see the link here: https://stm.bookpi.org/ACPR-V5/article/view/13286
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