Diabetes is one among the top ten leading killers of human
population. Epidemiological studies revealed that diabetes is being increased
due to exposure to pollutants. Alkylating agents are one such group of
pollutants, which are also being used as anticancer agents. Even though, we use
alkylating agents as antineoplastics, their influence in diabetic condition in
human has not been worked out. Hence, mouse as a model organism was used to
induce diabetic condition and the same has been employed to test the well known
two alkylating agents such as ethyl methanesulfonate (EMS) and methyl
methanesulfonate (MMS). These agents were tested to understand their influence
on biochemical parameters and on chromosomes. The results have revealed that
these agents drastically affect the different biochemical parameters. Further,
for the first time it has been demonstrated that these agents induce less
chromosomal aberrations in diabetic mouse compared to non-diabetic. These
results are discussed with relevant literature.
Author(s) Details:
Vasudev V.,
University of Mysore, P.G Centre, Hemagangotri, Hassan-573220,
Karanataka, India.
Khalandar B. B. D.,
Department
of Bioscience University of Mysore, P.G Centre, Hemagangotri, Hassan-573220,
Karanataka, India.
Please see the link here: https://stm.bookpi.org/ANUMS-V5/article/view/13302
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