Effects of Anticancerous Drugs- EMS and MMS in Induced Diabetic Mouse: Differential Response of Biochemical Parameters and Dose Effect Relationship of Chromosomal Aberrations | Chapter 2 | Advancement and New Understanding in Medical Science Vol. 5

Diabetes is one among the top ten leading killers of human population. Epidemiological studies revealed that diabetes is being increased due to exposure to pollutants. Alkylating agents are one such group of pollutants, which are also being used as anticancer agents. Even though, we use alkylating agents as antineoplastics, their influence in diabetic condition in human has not been worked out. Hence, mouse as a model organism was used to induce diabetic condition and the same has been employed to test the well known two alkylating agents such as ethyl methanesulfonate (EMS) and methyl methanesulfonate (MMS). These agents were tested to understand their influence on biochemical parameters and on chromosomes. The results have revealed that these agents drastically affect the different biochemical parameters. Further, for the first time it has been demonstrated that these agents induce less chromosomal aberrations in diabetic mouse compared to non-diabetic. These results are discussed with relevant literature.

Author(s) Details:

Vasudev V.,
University of Mysore, P.G Centre, Hemagangotri, Hassan-573220, Karanataka, India.

Khalandar B. B. D.,
Department of Bioscience University of Mysore, P.G Centre, Hemagangotri, Hassan-573220, Karanataka, India.

Please see the link here: https://stm.bookpi.org/ANUMS-V5/article/view/13302

Mobile Multimedia Messaging Service Teleradiology- in Otorhinolaryngological Emergencies: Brief Overview | Chapter 10 | Research Trends and Challenges in Medical Science Vol.3

Introduction: The diagnosis of many otolaryngological emergencies is based on radiological investigations likex-rays and CT-Scans. The reliability of the mobile phone digital images of emergency radiological investigations send via multi-media messaging, a cheap and rapid modality for telemedicine, has not been explored for otolaryngological emergencies.  Objective: The present article explores its benefit as a tool for medical communication, especially for consultation by the resident doctors in situations where specialists are not immediately available. Methods: Certain otolaryngology emergencies like faciomaxillary trauma, foreign bodies and infective emergencies, may need urgent imagingin the form of X-rays, Computed Tomography (CT-Scan) or Magnetic Resonance Imaging (MRI) for diagnosis. Various studies related to Mobile Multimedia Service (MMS) teleradiology in Otolaryngological emergencies were reviewed. The digital images of the radiographs viewed on an illuminated view box in Ear Nose and Throat (ENT) emergency, clicked under constant environment, including same resident doctor and cell phone with camera equipped with mobile multimedia message service (MMS) were sent via MMS to another phone of the same make and model, with blinding to avoid observer bias. The cell phone digital images (index test) have been compared with reporting of the actual radiograph films viewed on a view box (reference standard) with regards to their diagnostic accuracy. Results: Mobile Multimedia Service (MMS) teleradiology has been found to have a diagnostic accuracy comparable to the actual radiographs (X-rays, CT-Scans, MRI) viewed on a view box or computer screen, for most of the otolaryngological emergencies except undisplaced fracture of nasal bones and surgical emphysema where the results were dependent on the technique of clicking the image and the resolution of the camera. Conclusion: Mobile Multimedia Service (MMS) teleradiology is a cheaper, quick and more easily accessible solution in medical communication and it can be incorporated as a handy and readily available communication tool for handling otolaryngological emergencies as it would enhance the confidence in remote decision making and improve patient care in emergency settings.

Author(s) Details
Dr. Shraddha Jain
Department of Otorhinolaryngology, Jawaharlal Nehru Medical College, Datta Meghe be University), Sawangi (M), Wardha, Maharashtra, India

Dr. Sunil Kumar
Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (M), Wardha, Maharashtra, India.

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