Background: Homoeopathy is a system of medicine in which the
indigenous and crude plant/ animal products are used in medicine. Extract of
Ferula asafoetida (Heeng) is commonly used as Homoeopathic drug to cure various
stomach related problems. There has been significant controversy associated
with the side effects of Homoeopathic drugs.
Methodology: The mother tincture of Ferula asafoetida has been collected from
RSBP Bulandshahar and Lord Pharmacy New Delhi, India. The effect of heeng as a
Homoeopathic drug on somatic cell division has been studied by the root tip
method. The effects of different concentrations of heeng on the chromosomes of
Vicia faba was investigated. 5%, 10%, 20% & 30% of Ferula asafoetida were
used for 4hrs, 8hrs, 12hrs and 24 hours followed by acetocarmine squash
procedure. All the concentrations showed mito-inhibitory effect in the root
tips of Vicia faba and also observed so many chromosomal aberrations
(clastogenic).
Results: The treated root tips showed various disturbances at the prophase,
metaphase and anaphase stages of mitotic cell division. Due to the stickiness
of chromosomes, the separation of chromosomes was affected by the formation of
chromatin bridges. The most observed aberrations were sticky chromosomes,
chromatin bridges, chromatin fragments and laggards at every stage of mitotic
division.
Conclusion: The result of the present study clearly established the
cytogenotoxic behaviour of heeng as a Homoeopathic drug. The dose and duration
should be tested for its various mutagenic and genotoxic properties in
different eukaryotic systems viz. animals and humans.
Author(s) Details:
Sangeeta Dayal,
Department of Bio-Technology and Botany, KVSCOS, Swami Vivekanand Subharti University, Meerut (U.P.), India.
Alka Noopur,
ABN Classes, Sec-10, Raj Nagar, Ghaziabad (U.P.), India.
Harshal Kumar,
National Bureau of Plant Genetic Resources, IARI PUSA, New Delhi, India.
Please see the link here: https://stm.bookpi.org/ACPR-V5/article/view/13448
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