The aim of the present study was to assess the toxicity of
Linga Chenduram by Analytical and Toxicological studies. Physicochemical
properties of Linga Chenduram were investigated analytically, and the drug's
solubility characteristics, density, melting point, and pH were determined.
X-Ray Fluorescence study revealed the presence of elements such as Mercury,
Sulfur, and Arsenic. The Mercuric
sulphide was identified as a main ingredient in test drug. Acute oral toxicity
study in Wistar albino rats was conducted as per the OECD Guidelines 401 and
420. Groups of animals of a single sex were dosed in a stepwise procedure using
the fixed doses of 5, 10, 50, 100, 250, 500, 1000, 2000, and 4000 mg/kg. There
was no significant toxicity in the treated group compared to control. Repeated
dose oral toxicity (sub-acute) study in Wistar albino rats (28 days) were
conducted as per the OECD Guideline 407. Twenty-four rats were selected and
divided into four groups of six rats each. The animals in group I (control)
received honey daily, while those in groups II, III, IV received 200, 400 and
600mg/kg of test drug, respectively, through the oral route for 28 days. There
was a significant increase in the level of TLC and Prothrombin time. In
contrast, the APTT and MCV level is gradually decreased by dose dependent
pattern. There was a significant decrease in the level of urea, potassium and
LDL. In contrast, the Total Cholesterol, VLDL and T3 level is increased. There
was degenerative change in brain and kidney, inflammatory change in liver and
congestion in lung and spleen in the high dose group (600mg/kg). The present
studies confirm the Linga Chenduram toxicity during prolonged administration of
very high doses (600mg/kg). The normal human dose of Linga Chenduram is 65 mg.
It is very minimal dose to compare the study group doses. If the test drug at
0.9mg /Kg /BW as per literature is given do not produce toxicity.
Author(s) Details:
S. Murugesan,
Department of Nanju Maruthuvam (Siddha Toxicology), National
Institute of Siddha, Tambaram Sanatorium, Chennai-47, India.
Please see the link here: https://stm.bookpi.org/ACPR-V5/article/view/13243
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