Association of IL-17A Gene Polymorphism and Its Influence on Serum IL-17A & IL-6 Levels in Diabetes with Chronic Periodontitis Patients | Book Publisher International

Interleukin-6 (IL-6) is an important cytokine which involved in the regulation of host immune response in systemic and periodontal infection. Interleukin-17 (IL-17) is a proinflammatory cytokine secreted by Th-17 cells and activate neutrophils which lead to chemokine expression. IL-17& IL-6 cytokines are reported to be associated with inflammatory conditions like rheumatoid arthritis, airway mucin secretion, asthma and type 1 & 2 diabetes mellitus and periodontitis.This study was done to find out whether there is any association between IL-17A & 6 cytokines and IL-17A gene polymorphism (Alleles) of chronic periodontitis in type 1 & 2 diabetes patients.This study was done on 359 subjects, and consists of 6 groups and these are group 1 which included of 28 patients from type I diabetes with periodontitis. The group-2 was patients from type 1 diabetes and without chronic periodontitis, there were 71 type 2 diabetic patients with chronic periodontitis in group 3 while 76 patients were included in group 4 and they had only type 2 diabetes. In the same way, there were total of 78 non diabetic patients in the group-5 with only chronic periodontitis. The last group 6 consists of nondiabetic patients and the sample size for this group was 78 patients and no one has periodontitis. The study showed that IL-17A polymorphism is significantly more associated with type 1 diabetes patients with chronic periodontitis (group-1). Individuals carrying the positive IL-17A genotype have greater risk for T1DM with periodontitis. IL-17A & 6 cytokines level used to identify the severity of the periodontal destruction with diabetes mellitus and It can consider as biomarker for disease activity.

Author(s) Details:

P. K. Sasikumar,
Department of Periodontics, JKKN Dental College and Hospital, JKKN Allied Health Sciences, Tamil Nadu, India.

Sheeja S. Varghese,
Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Chennai, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/AIGPIISIILDCPP/article/view/13257

Qualitative assessment of Helicobacter pylori by PCR in the saliva of Male Smokers and Non-Smokers with Chronic Periodontitis | Chapter 14 | Novel Research Aspects in Medicine and Medical Science Vol. 5

 Helicobacter pylori (H. pylori), a rational resident of the pertaining to the stomach environment, has also happened found in the spoken environment of humans. Various studies have befriended the presence of H. pylori in the spoken environment of subjects accompanying periodontitis suggesting that progression of periodontal pocket and redness may favor settling by this bacterium. One of the major risk determinants for periodontitis is smoking. Smokers have raised prevalence and severe in consideration of periodontal disease, in addition to a higher prevalence of premolar loss distinguished to non-smokers. This chapter aims to evaluate the comparative presence of H. pylori in the slobber of smokers and nonsmokers with never-ending periodontitis. A total of 48 male individuals diagnosed accompanying chronic periodontitis (CAL≥5mm) accompanying and without hot habits were enrolled in the study. The unstimulated whole slaver was subjected to H. pylori DNA discovery using real-occasion PCR. The percent closeness of H. pylori DNA among the groups was statistically compared.Periodontal limits (gingival index, plaque index, acute depth, and dispassionate attachment level) were significantly various between smokers and non-smokers distinguished to controls (P =.001). Overall, H. pylori was not detected in controls (100% negative), whereas 5.5% of non-smokers and 13.3% of smokers revealed the presence of H. pylori. The Chi-square test presented a significant difference (P =.003) betwixt smokers and controls; however, it was visualized that the relative differences with the groups could not reach statistical importance. The study revealed that smokers accompanying chronic periodontitis may bother a relatively greater risk of H. pylori presence in the oral crater than non-smokers.

Author(s) Details:

Rajeev Kishore Saxena,
Department of Microbiology, Abhishek I. Mishra Memorial Medical College and Research, Junwani, Bhilai, India.

Abdul Samad Aziz,
Department of Biochemistry, Dr. G. D. Pol Foundation’s YMT Dental College and Hospital, Kharghar, Navi-Mumbai, India.

Madhav Govind Kalekar,
Department of Biochemistry, Grant Medical College and Sir J. J. Group of Hospitals, Byculla, Mumbai, India.

J. P. Milsee Mol,
Department of Biotechnology, Sinhgad College of Science, Pune, India.

Adinath Narayan Suryakar,
FACBI, Registrar, Maharashtra University of Health Sciences, Nashik, India.

Benjamin Tabita,
Department of Dentistry, Grant Medical College and Sir J. J. Group of Hospitals, Byculla, Mumbai, India.

Ravi Vasudev Shirahatti,
Department of Public Health Dentistry, Sinhgad Dental College, Pune, India.

Raghavendra Shrishail Medikeri,
Department of Periodontics, Sinhgad Dental College, Pune, India.

Please see the link here: https://stm.bookpi.org/NRAMMS-V5/article/view/12179

Evaluation of Chronic Periodontitis as a Risk Factor for Head and Neck Squamous-cell Carcinoma and Impact on Quality of Life| Chapter 14 | Issues and Developments in Medicine and Medical Research Vol.10

 Background and Objectives: There is a strong link between chronic infections/inflammation and cancer. The goal of this study was to see how chronic periodontitis affected individuals with head and neck squamous-cell cancer (HNSCC) and how it affected their quality of life.

Materials and Procedures: A total of 46 patients were included in the trial, divided into two groups. Patients with primary HNSCC (n=26) were included in the study. The controls (n=20) were all patients who were seen at the same time but were not diagnosed with cancer. On standardised panoramic radiographs, the bleeding index, periodontal index, tooth mobility degree, and alveolar bone loss (ABL) were used to determine the severity of periodontitis. Before the diagnosis was made, all patients were asked to complete a questionnaire on their quality of life.
The researchers discovered that every centimetre of ABL was linked to a four-fold greater risk of HNSCC. The oral cavity had the strongest link, with the oropharynx and larynx following closely behind. The link was still there in participants who had never consumed cigarettes or alcohol. Patients with periodontitis were more likely to have poorly differentiated oral cavity SCC than those without periodontitis, with higher bleeding and periodontal indices and tooth mobility values (32.8 percent versus 11.5 percent; P = 0.038). When compared to the control group, the patients in the study group had greater questionnaire point values.
Conclusions: Chronic periodontitis appears to be a risk factor for the development of HNSCC in our investigation. These findings have implications for more practical and effective HNSCC prevention, diagnostic, and treatment techniques.

Author(s) Details:

Prof. Silvia Martu,
Department of Periodontology, Faculty of Dental Medicine, “Gr. T. Popa” UMPh, IASI, Romania.

Dr. Cornelia Teodorescu,
Department of Periodontology, Faculty of Dental Medicine, “Gr. T. Popa” UMPh, IASI, Romania.

Mr. Bogdan Vasiliu,
Department of Periodontology, Faculty of Dental Medicine, “Gr. T. Popa” UMPh, IASI, Romania.

Dr. Ioana Martu,
Department of Thechnology of Dental Prospheses, Faculty of Dental Medicine, “Gr. T. Popa” UMPh, IASI, Romania.

Diana-Cristala Kappenberg-Nitescu,
Department of Periodontology, Faculty of Dental Medicine, “Gr. T. Popa” UMPh, IASI, Romania.

Irina Sufaru,
Department of Periodontology, Faculty of Dental Medicine, “Gr. T. Popa” UMPh, IASI, Romania.

Ionut Luchian,
Department of Periodontology, Faculty of Dental Medicine, “Gr. T. Popa” UMPh, IASI, Romania.

Victor Vlad Costan,
Department of Oral and Maxillo Facial Surgery, Faculty of Dental Medicine, “Gr. T. Popa” UMPh, IASI, Romania.

Sorina Solomon,
Department of Periodontology, Faculty of Dental Medicine, “Gr. T. Popa” UMPh, IASI, Romania.

Liliana Pasarin,
Department of Periodontology, Faculty of Dental Medicine, “Gr. T. Popa” UMPh, IASI, Romania.

Please see the link here: https://stm.bookpi.org/IDMMR-V10/article/view/5829

Determination of Relationship between Chronic Periodontitis and Metabolic Syndrome | Chapter 15 | Recent Developments in Medicine and Medical Research Vol. 9

 Chronic periodontitis is a long-term inflammatory disorder of the mouth that affects the teeth's supporting components. It causes tooth loss, bone loss, and attachment loss. Recent studies have linked it to diabetes, cardiovascular illness, cerebrovascular disease, pulmonary disease, obesity, and pre-term low birth weight kids, among other systemic disorders affecting the body. Diabetes, stroke, and cardiovascular disease are all symptoms of metabolic syndrome, which is a group of disorders. In light of the foregoing, the purpose of this study was to determine the link between chronic periodontitis and metabolic syndrome.

The study's goals were to compare the periodontal health of metabolic syndrome patients to that of healthy people in general.

II. Determine whether the periodontal state corresponded to the metabolic component readings.

Methods: This study included a total of ninety patients. Group one consisted of 45 patients with metabolic syndrome who were confirmed, while group two comprised of 45 healthy controls who were age and sex matched. Plaque index, Ainamo & Bay Gingival Bleeding Index, Probing Pocket Depth (PPD), Clinical Attachment Level (CEJ), total number of missing teeth, and causes for extraction were all recorded. Height, weight, waist circumference, waist-hip ratio, BMI, serum lipid profile, fasting blood glucose, and blood pressure were all measured as part of the medical examination and blood tests. The NCEP ATP III definition of metabolic syndrome was used. Using the SYSTAT html output, the findings were statistically analysed.

Results: In comparison to group two patients, the periodontal condition of group one patients was poor, according to the findings of this study. The periodontal condition deteriorated as the metabolic components increased.

Conclusion: Based on the findings of this study, it can be stated that periodontitis and metabolic syndrome were interfering with each other's systemic effects. Dentists should educate their patients about the dangers of metabolic syndrome and periodontitis, as well as encourage them to practise proper dental hygiene and live a healthy lifestyle.

Author(S) Details

Manovijay Balagangadharan
Department of Periodontology, Vinayaka Mission’s Sankarachariyar Dental College affiliated to Vinayaka Mission’s Research Foundation(Deemed to be University), Ariyanoor, Salem, Tamilnadu State, India.

Mythili Swaminathan
Department of Periodontology, Rajah Muthiah Dental College and Hospital, Annamalai University, Chidambaram, Tamilnadu State, India.

View Book:- https://stm.bookpi.org/RDMMR-V9/article/view/4597