Investigating the Therapeutic Effect of Combined Colon Clear and Cupping Therapy on Idiopathic Skin Pathology: A Prospective Study | Chapter 1 | Disease and Health: Research Developments Vol. 4

The complex spectrum of inflammatory skin diseases is ever-expanding and evolving, particularly in psoriasis, idiopathic eczema and atopic dermatitis. The study aimed at demonstration of idiopathic skin pathology; influence of Helicobacter pylori and therapeutic effect of combined colon clear with cupping therapy. Idiopathic eczema is an atopic inflammatory skin disease which has got mostly a chronic relapsing course with seasonal variation and marked influence of emotional stress.

The complex spectrum of inflammatory skin diseases is ever expanding and evolving particularly in psoriasis, idiopathic eczema and atopic dermatitis. The etiology of these inflammatory atopic dermato-pathological disorders is still obscure but it is basically autoimmune triggered and maintained by an aberrant response of the skin immune system cells. Pro-inflammatory cytokines play a pivot role in the pathogenesis of immune skin pathologies. This prospective study done in Balghsoon Clinics in Jeddah, Saudi Arabia between October 2011 and May 2013. H. pylori could migrate or get forced to migrate to the colon leading to accumulation of profuse toxic amounts of ammonia unopposed or buffered by any acidity. The association of H. pylori with autoimmune disorders and chronic idiopathic dermatitis was sufficiently reported. The role played by the increased mucosal production of inflammatory mediators (cytokines) induced by H. pylori was also clearly illustrated. Antibiotics are seldom effective against extra-gastric H. pylori strains. A potent natural purgative is the only measure to eradicate H. pylori strains migrated to the colon. Elimination of toxic metabolites and inflammatory mediators from the body is a challenge which is only feasible via seroclearance blood-let out cupping therapy. The management of atopic dermatitis primarily focuses on restoring the skin barrier, controlling itch, and reducing inflammation. 

Seven patients with atopic dermatitis, seven with idiopathic eczema and seven with psoriasis were randomly included in the study on the basis of being newly discovered, not starting any definitive treatment and having a frank history of H. pylori dyspepsia which was proved by sensitive specific tests. All patients underwent colon clear employing the potent natural senna purge which was followed in five days by a session of blood-let out seroclearance cupping therapy on the upper back.

Marked improvement as regards the scales, itchiness and discoloration was  seen in 5 patients with dermatitis, 6 patients with eczema and 4 patients with psoriasis after colon clear. Improvement was much more marked after cupping therapy.

 

Author (s) Details

Abdullah M Nasrat
Department of Surgery, Balghsoon Clinic, Jeddah, KSA.

 

Salwa AM Nasrat
Department of Physical Therapy, Cardiac Surgery Academy, Cairo, Egypt.

 

Randa M Nasrat
Department of Internal Medicine, Helwan General Hospital, Helwan, Egypt.

 

Mohammad M Nasrat
Department of Internal Medicine, Helwan General Hospital, Helwan, Egypt.

 

Sanaa Y Babiker
Faculty of Medicine, Elrazi University, Medina, KSA.

 

Please see the book here:- https://doi.org/10.9734/bpi/dhrd/v4/3639

Helicobacter pylori and Hyperuricemia: Revisiting Gout Diagnosis in Young Adults with Normal Renal Function | Chapter 1 | Medical Science: Trends and Innovations Vol. 4

Gout is a very old disease which existed for thousands of years with joint swelling, pain or tenderness; the first description of symptoms of gout was found in the Egyptian medical papyri dating to 3000 years BC. The study aimed to illustrate that the detection of high levels of serum uric acid in young adults with perfect kidney function should not be considered the final diagnosis of hyperuricemic pre-gouty illness. Gout is a very old disease which existed for thousands of years with joint swelling, pain or tenderness. Hyperuricema has long been established as the major etiologic factor in gout. Gout has recently become the most common presentation of arthritis in developed countries. Hyperuricemia increases the risk of gout and is also a risk factor for cardiovascular diseases.

Hyperuricemia could contribute to diabetes, hypertension and arteriosclerosis due to endothelial dysfunction triggered by vascular wall tissue inflammation because of urate crystal deposition. These reasons are sufficient to render physicians anxious in the immediate assessment and treatment of elevated serum uric acid levels. On the contrary, patients hesitate to accept the decision of their pre-gouty illness due to elevation of serum urate particularly if they are young and have perfect renal function. H. pylori could migrate or get forced to migrate to the colon leading to colonic re-absorptive error with excess accumulation of fluids and salts in the body; uric acid could be among these reabsorbed elements giving a picture of elevated serum uric acid levels that would have no relation to age of the individual or the integrity of his renal function. Furthermore, gout has been recently considered as one of the auto-inflammatory diseases, hence cytokines are the most common mediators of inflammation; therefore, the role played by the increased mucosal production of inflammatory mediators (cytokines) induced by H. pylori is supposed to contribute to the pathogenesis of gout. In this situation, hyperuricemia is not expected to be adequately or successfully improved by traditional urate-lowering measures regardless of the age of the patient or the state of his kidney function.

Thirty-three patients aged between 31-40 years, having normal kidney function and a frank history of H. pylori dyspepsia were included in the study due to newly discovered elevated levels of serum uric acid regardless of their body built or any associated. The existence of colonic H. pylori strains was proved by the H. pylori fecal antigen test. All patients underwent colon clear employing the potent natural senna purge once and colon care was maintained by vinegar-mixed food therapy for one week. Serum uric acid levels dropped to normal within 3 days after the colon cleared in 30 patients while the remaining 3 patients showed the same drop at the end of the first week of natural therapy. Detection of high levels of uric acid in young adults should not be considered as a final diagnosis of pre-gouty illness unless kidney function is assessed, and the association of H. pylori is excluded by specific tests. Revision of the guidelines for the diagnosis and treatment of H. pylori and many chronic diseases associated with it may be needed.

 

Author (s) Details

Abdullah M Nasrat
Department of Surgery, Balghsoon Clinic, Jeddah, Saudi Arabia.

Salwa AM Nasrat
Department of Physical Therapy, Cardiac Surgery Academy, Cairo, Egypt.

 

Randa M Nasrat
Department of Internal Medicine, Helwan General Hospital, Helwan, Egypt.

 

Mohammad M Nasrat
Department of Internal Medicine, Helwan General Hospital, Helwan, Egypt.

 

Sana Y Babiker
Faculty of Medicine, Elrazi University, Sudan.

 

Please see the book here:- https://doi.org/10.9734/bpi/msti/v4/3641

Qualitative assessment of Helicobacter pylori by PCR in the saliva of Male Smokers and Non-Smokers with Chronic Periodontitis | Chapter 14 | Novel Research Aspects in Medicine and Medical Science Vol. 5

 Helicobacter pylori (H. pylori), a rational resident of the pertaining to the stomach environment, has also happened found in the spoken environment of humans. Various studies have befriended the presence of H. pylori in the spoken environment of subjects accompanying periodontitis suggesting that progression of periodontal pocket and redness may favor settling by this bacterium. One of the major risk determinants for periodontitis is smoking. Smokers have raised prevalence and severe in consideration of periodontal disease, in addition to a higher prevalence of premolar loss distinguished to non-smokers. This chapter aims to evaluate the comparative presence of H. pylori in the slobber of smokers and nonsmokers with never-ending periodontitis. A total of 48 male individuals diagnosed accompanying chronic periodontitis (CAL≥5mm) accompanying and without hot habits were enrolled in the study. The unstimulated whole slaver was subjected to H. pylori DNA discovery using real-occasion PCR. The percent closeness of H. pylori DNA among the groups was statistically compared.Periodontal limits (gingival index, plaque index, acute depth, and dispassionate attachment level) were significantly various between smokers and non-smokers distinguished to controls (P =.001). Overall, H. pylori was not detected in controls (100% negative), whereas 5.5% of non-smokers and 13.3% of smokers revealed the presence of H. pylori. The Chi-square test presented a significant difference (P =.003) betwixt smokers and controls; however, it was visualized that the relative differences with the groups could not reach statistical importance. The study revealed that smokers accompanying chronic periodontitis may bother a relatively greater risk of H. pylori presence in the oral crater than non-smokers.

Author(s) Details:

Rajeev Kishore Saxena,
Department of Microbiology, Abhishek I. Mishra Memorial Medical College and Research, Junwani, Bhilai, India.

Abdul Samad Aziz,
Department of Biochemistry, Dr. G. D. Pol Foundation’s YMT Dental College and Hospital, Kharghar, Navi-Mumbai, India.

Madhav Govind Kalekar,
Department of Biochemistry, Grant Medical College and Sir J. J. Group of Hospitals, Byculla, Mumbai, India.

J. P. Milsee Mol,
Department of Biotechnology, Sinhgad College of Science, Pune, India.

Adinath Narayan Suryakar,
FACBI, Registrar, Maharashtra University of Health Sciences, Nashik, India.

Benjamin Tabita,
Department of Dentistry, Grant Medical College and Sir J. J. Group of Hospitals, Byculla, Mumbai, India.

Ravi Vasudev Shirahatti,
Department of Public Health Dentistry, Sinhgad Dental College, Pune, India.

Raghavendra Shrishail Medikeri,
Department of Periodontics, Sinhgad Dental College, Pune, India.

Please see the link here: https://stm.bookpi.org/NRAMMS-V5/article/view/12179

The Current Situation of Helicobacter Pylori Infection in Africa | Chapter 1 | Current Innovations in Disease and Health Research Vol. 7

 The aim concerning this study is to ease a working plan for the situation of H. pylori in Sub-Saharan Africa. Whilst different noninvasive and obtrusive tests are used for disease skilled is a need to reach a common direction in Sub-Saharan Africa for the treatment and disease of H. pylori. The treatment process adopted has happened demonstrated to decide the efficacy of H. pylori extermination. Treatment failures in Africa are mainly caused by fighting to medicines and a lack of healthcare infrastructure.This review specifies the challenges in Africa in diagnosing and treating H. pylori contamination together with the lack of situation guidelines and lack of decent protocol for disease. Another issue is a lack of healthcare infrastructure. H. pylori contamination is common in Africa, and drug opposition amounts to the infection's burden.

Author(s) Details:

Richard Wismayer,
Department of Surgery, Masaka Regional Referral Hospital, Masaka, Uganda and Department of Surgery, Faculty of Health Sciences, IUIU University, Kampala, Uganda.

Please see the link here: https://stm.bookpi.org/CIDHR-V7/article/view/12039

Important Aspects of Toll-like Receptors: Signaling Pathways in Diseases | Book Publisher International

 Toll-like receptors (TLRs) are a group of receptors that serve as the body's first line of defence against microorganisms. They can detect invading pathogens as well as endogenous danger compounds generated by dying cells and damaged tissues, and they serve an important role in bridging the gap between innate and adaptive immunity. TLRs are found in a wide range of immune and non-immune cells. TLR expression and location are altered in response to pathogen-derived or damaged host-cell-derived chemicals. When ligands bind to TLR, they trigger intracellular signalling cascades that launch host defence responses. Recent research has discovered that gastrointestinal epithelial cells express nearly all TLR subtypes known to date, and that TLR expression and activation throughout the GI tract are closely regulated and coordinated. An excessive host defence reaction of the intestinal epithelium to endogenous luminal bacterial flora may be responsible for the initiation and persistence of inflammatory intestinal responses in inflammatory bowel disease (IBD). Several functional Toll-like receptors (TLRs) are expressed constitutively in intestinal epithelial cell lines, and they appear to be essential regulators of the innate response system. Stomach epithelial cells are the first line of defence against H. pylori, and they respond to infection by triggering a series of cell signalling cascades that result in cytokine production and the recruitment of inflammatory cells to the gastric mucosa. Many of these cell signalling processes are mediated by pathogen recognition receptors from the Toll-like receptor (TLR) family. Signaling downstream of toll-like receptors on immunological and resident vascular cells can elicit proinflammatory cytokine release, lipid uptake, and foam cell production, as well as activate cells of the adaptive immune system, which can alter atherogenesis. TLR1, -2, -3, -4, and -6 are expressed by tubular epithelial cells, which suggests that these TLRs may have a role in the activation of immune responses in tubulointerstitial damage (e.g., bacterial pyelonephritis, sepsis, and transplant nephropathy). Several studies have revealed that Toll-like receptors are an important part of our microbial defence system, but their potential involvement as mediators in allergies and asthma has yet to be determined. Toll-like receptor 4, a pathogen-associated molecular pattern receptor that initiates an inflammatory cascade in response to different CNS stimuli, is an essential contributor to microglial activation.

Author(S) Details

Najah R. Hadi
Professor and Consultant, Faculty of Medicine, University of Kufa, Iraq.

Saad Rasool Shaker
Alzahra Teaching Hospital, Alnajaf Health Directorate, Iraq.

Nada R. Alharis
Professor of Diagnostic Radiology Faculty of Medicine University of Kufa Iraq.

View Book:- https://stm.bookpi.org/IATLRSPD/article/view/3432