Vitiligo and Autoimmune Thyroid Disorders: Is There Any Correlation? | Chapter 8 | Recent Updates in Disease and Health Research Vol. 1

Background: Within the landscape of rising skin disorders, a substantial portion is rooted in autoimmune etiology, often showcasing manifestations of systemic pathologies. This chapter explores the intricate association between autoimmune thyroid disorders and Vitiligo, a skin condition marked by progressive melanocyte loss.  Emphasis is placed on elucidating the prevalence of thyroid autoantibodies in vitiligo patients, specifically Anti-thyroid peroxidase (anti-TPO Ab) and antithyroglobulin (anti-TG Ab) Antibodies. 

Research Methodology: A comprehensive hospital-based case-control study encompassing 60 participants was conducted to unravel the complex relationship between thyroid autoimmunity and dermatological disorders, such as psoriasis, melasma, atopic dermatitis, and Vitiligo.  Noteworthy findings indicate a robust association between autoimmune thyroid disorders and Vitiligo, with elevated thyroid Antibody levels observed in vitiligo cases compared to controls.

Key Results: The prevalence of autoimmune thyroid disease in vitiligo patients surpasses that of the general population, underscoring the imperative for systematic screening and heightened awareness.  In-depth biochemical analyses unveil significant disparities in thyroid hormone profiles and Antibody levels between vitiligo cases and controls, hinting at a potential role of thyroid dysfunction in the etiopathogenesis of Vitiligo.

Conclusion and Implications: This chapter contributes substantively to the burgeoning body of evidence supporting the nexus between autoimmune thyroid disorders and Vitiligo.  Exploring underlying mechanisms and shared genetic factors is a foundation for informed clinical practices.  The insights from this study pave the way for enhanced patient care and the development of tailored treatment strategies for those navigating the complexities of coexisting autoimmune conditions.  The imperative of early detection and management of thyroid autoimmunity in vitiligo patients is emphasized, offering practical guidance to healthcare professionals engaged in the nuanced care of individuals grappling with autoimmune skin disorders.

Author(s) Details:

Praveen Prashant,
Department of Biochemistry, Pt BD Sharma PGIMS Rohtak, Haryana, India.

Usha Kataria,
Department of Dermatology, Venereology and Leprology, BPS GMC for Women Khanpur Kalan, Sonepat, Haryana, India.

Sonia Vashist,
Department of Dermatology, Venereology and Leprology, Tripti Hospital, Rohtak, Haryana, India.

Piyush Bansal,
Department of Biochemistry, BPS GMC for Women Khanpur Kalan, Sonepat, Haryana, India.

Abhishek Bansal,
Department of Biochemistry, Pt BD Sharma PGIMS Rohtak, Haryana, India.

Please see the link here: https://stm.bookpi.org/RUDHR-V1/article/view/13216

Herbal Medicine: A New Ray of Hope for Vitiligo Patients| Chapter 5 | Current Overview on Pharmaceutical Science Vol. 3

 Vitiligo is a depigmentation disorder accompanying complex causes. Nonetheless, recent progress has happened made to untangle the pathophysiology of vitiligo. In this chapter, we provide an survey of the herbs that have been secondhand in clinical studies to treat vitiligo and focal point herbs that are known expected effective. Herbs containing Ammi visnaga L., Camellia sinensis, Ginkgo biloba, and Psoralea corylifolia L. have been highlighted by way of their traditional requests. The research for vitiligo drugs today demands enormous exertion. We strongly trust that this chapter may help to justify the use of a novel herbal cure in the treatment of vitiligo.

Author(s) Details:

Shaikh Habeeba,
Department of Pharmacy, Matoshri Institute of Pharmacy, Nashik, Maharashtra, India.

Shaikh Siddiqua,
Department of Pharmacy, Matoshri Institute of Pharmacy, Nashik, Maharashtra, India.

Please see the link here: https://stm.bookpi.org/COPS-V3/article/view/9110

Advanced Treatment of Vitiligo, a Study of Needling + UVB for Vitiligo | Chapter 17 | Recent Developments in Medicine and Medical Research Vol. 9

 Vitiligo is an ever-increasing condition that affects people of all ages around the world. Sun exposure, UVR, oral and topical psoralens are all used in different regimens. NEEDLING is paired with narrow band UVB radiation in our study, which is an innovative effort with a novel concept. The Melanocytes in the normal skin around the vitiligo patch can be pushed into the vitiligo patch, and subsequent UVB induced melanogenesis heals vitiligo, according to our hypothesis.

Methods: A 30-G needle with a short stem is gently placed parallel to the skin through the normal skin edge into the vitiligo patch at the level of the D-E junction. NEEDLING pulls epidermal cells, including melanocytes, as a micro inoculation, resulting in several small populations of melanocytes in the vitiligo area, which are subsequently exposed to narrow band UVB, causing melanogenesis and thereby repigmentation of the area. One centimetre apart, many needle pushes are conducted through the edge into the vitiligo patch. Needling is done once a week for all patients, and UVB is done three times a week.

From July 2009 through July 2016, a study of this combination was conducted on 300 patients of both sexes in various age groups, with follow-up continuing. In several of these individuals, a comparison with UVB alone (without needling) was made at some patches. It was decided on inclusion and exclusion criteria, as well as a result criteria and a study Performa with follow-up information. All of the patients' photos were taken in the beginning and then every three weeks after that. A few patients were biopsied to see how the needling affected them.

In comparison to UVB alone, this combined treatment has proven to be quite safe and effective against vitiligo in all age groups. All of the patients saw rapid repigmentation. The face has the best outcomes, with more than 90% repigmentation in all age categories. Repigmentation is still good, but it is slower in the periphery. Repigmentation was observed to begin at the periphery of the vitiligo patch (where needling begins) as little black dots, with subsequent needling through these spots eventually repigmenting the centre portions. Because needling employs melanocytes from the skin around the vitiligo patch rather than follicular cells, repigmentation is also possible over areas with grey hair. This bolstered the case for needling as an effective adjunct to UVB therapy.

Author(S) Details

M. I. Sheikh
Consultant Dermatologist, Alhamd Skin Clinic, Pakistan.

View Book:- https://stm.bookpi.org/RDMMR-V9/article/view/4600

Unusual Presentation of Post Viteriolage Depigmentation without Superficial and Deep Cutaneous Injury | Chapter 2 | Research Trends and Challenges in Medical Science Vol. 10

 Depigmented macules on the body of a 45-year-old male patient had been present for 6 weeks. Multiple patterned, circumscribed, depigmented macules involving the trunk and limbs were discovered during the examination. Due to close contact with a few drops of the same acid, a few punctuate and longitudinal depigmented macules were present on the right knee and leg. After a family feud, the patient reported that lesions appeared as a result of acid exposure. Dilute sulphuric acid, condensed sulphuric acid, glacial acetic acid, hydrochloric acid, dilute acetic acid, muriatic acetic acid, and sodium bisulphate were all patch tested. Hydrochloric acid was found to be the most effective of all the acids analysed.

Author (s) Details

Anupama Sharma
Department of Chemistry, Jaypee University, Anoopshahr, Bulandshahr, U.P, India

Girish C. Sharma
Department of Chemistry, Jaypee University, Anoopshahr, Bulandshahr, U.P, India

Khozema Saify
Saify Skin Clinic, Thatipur, Gwalior (M.P), India

View Book :- https://stm.bookpi.org/RTCMS-V10/article/view/705

Vitiligo and Thyroid Autoimmunity | Chapter 2 | Innovations in Medicine and Medical Research Vol. 3

Vitiligo is an acquired skin disorder characterized by depigmented maculae resulting from a reduction or the number and function of melanocytes. It is characterized by macular depigmentation of varying sizes or shapes with a tendency to progress. The etiopathogenesis of the disease is still unclear, but there is evidence that autoimmunity and endocrine dysfunction may be involved. Vitiligo has been reported in association with numerous endocrine disorders. One of the main association is with thyroid abnormalities. Thyroid autoimmunity is the most prevalent autoimmune condition in the general population, and is also associated with various skin diseases. The mechanisms by which these diseases develop are unknown, although it is likely that diseases occur in genetically susceptible individuals exposed to a permissive environment.  This chapter is an attempt to update the current knowledge about the relationship between vitiligo and thyroid autoimmunity. Although cutaneous manifestation of autoimmune thyroid diseases are well described, a better understanding of these processes is needed. It is a multidisciplinary problem requiring cooperation of specialist in different fields of medicine. Both dermatologist and endocrinologists have to inquire their patients about the family history of autoimmune diseases and to look for associated disorders. 

Author(s) Details 

 Emina Kasumagic-Halilovic
Department of Dermatovenereology, Clinical Center University of Sarajevo, Bosnia and Herzegovina.

Nermina Ovcina-Kurtovic
Department of Dermatovenereology, Clinical Center University of Sarajevo, Bosnia and Herzegovina.

View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/178