Vitiligo is an acquired skin disorder characterized by
depigmented maculae resulting from a reduction or the number and function of
melanocytes. It is characterized by macular depigmentation of varying sizes or
shapes with a tendency to progress. The etiopathogenesis of the disease is
still unclear, but there is evidence that autoimmunity and endocrine
dysfunction may be involved. Vitiligo has been reported in association with
numerous endocrine disorders. One of the main association is with thyroid abnormalities.
Thyroid autoimmunity is the most prevalent autoimmune condition in the general
population, and is also associated with various skin diseases. The mechanisms
by which these diseases develop are unknown, although it is likely that
diseases occur in genetically susceptible individuals exposed to a permissive
environment. This chapter is an attempt
to update the current knowledge about the relationship between vitiligo and
thyroid autoimmunity. Although cutaneous manifestation of autoimmune thyroid
diseases are well described, a better understanding of these processes is
needed. It is a multidisciplinary problem requiring cooperation of specialist
in different fields of medicine. Both dermatologist and endocrinologists have
to inquire their patients about the family history of autoimmune diseases and
to look for associated disorders.
Author(s) Details
Emina
Kasumagic-Halilovic Author(s) Details
Department of Dermatovenereology, Clinical Center University of Sarajevo, Bosnia and Herzegovina.
Nermina Ovcina-Kurtovic
Department of Dermatovenereology, Clinical Center University of Sarajevo, Bosnia and Herzegovina.
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