Mupirocin Emulgel: Formulation and Evaluation for the Management of Primary and Secondary Infections in Dry Skin Conditions | Chapter 6 | Pharmaceutical Science: New Insights and Developments Vol. 4

Background: Dry skin is a frequent and multifaceted condition which can be associated with skin irritation, itch, patient discomfort and manifest skin disease. The most common skin conditions where dry skin may be a symptom include ichthyosis, psoriasis, and dermatitis/eczema. Primary and secondary infections can occur in these conditions.

Objective: By overcoming the demerits of ointments, creams, and lotions, the goal of the formulation of mupirocin emulgel was to improve the occlusive properties of gels and topical delivery of hydrophobic mupirocin drugs in primary and secondary infections of dry skin conditions with favorable properties, as well as to investigate the impact of the concentration of different gelling agents (carbopol 940, carbopol 934, xanthan gum) on viscosity and the drug release of prepared.

Materials and Methods: Oil, an emulsifier, a co-surfactant, and three different types of gelling agents, such as Carbopol 940, Carbopol 934, and xanthan gum, were used to make the emulgel. The physical characteristics, pH measurement, spreadability, drug content, rheological study, and in vitro drug release of each prepared emulgel were evaluated. Researchers also looked at skin sensitivity, ex vivo penetration and skin retention, antibacterial effectiveness, and stability of the mupirocin emulgel formulation.

Results: Both carbomer and xanthan gum exhibit excellent water retention and are quite effective. Excellent homogeneity, an acceptable pH, spreadability, and medication consistency were all features of newly developed emugels. The mupirocin formulation made with carbopol 934(0.8 percent w/w), which is the F4 batch, demonstrated the greatest drug release at 82.54±0.39 percent and optimal viscosity at 4117.0± 0.59 among all emulgel formulations. Drug release from all the preparations depended upon the concentration of the gelling agent used. Viscosity rises and medication release falls with increasing gelling agent concentration. The improved formulation had good antibacterial activity, was stable, didn’t irritate the skin, and exhibited improved retention in the skin.

Conclusion: Carbopol 934 gelling agents are advised for the creation and manufacturing of mupirocin emulgels for topical medication delivery.

 

Author (s) Details

 

Rajashri Namdev Kausdikar
Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.

Manish S Kondawar
Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.

Fahim J Sayyad
Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/psnid/v4/4713

Novel Herbal Gel Formulation of Terminalia chebula Retz., Plant | Chapter 7 | Pharmaceutical Science: New Insights and Developments Vol. 1

A novel approach was adopted for developing a herbal gel using Terminalia chebula Retz., a plant revered as the "King of Medicine" in Tibetan traditional medicine. This plant thrives in tropical and subtropical regions of East Asia at altitudes of up to 2000 meters, with optimal growth conditions in areas receiving 100–150 cm of annual rainfall and temperatures ranging between 0–17°C. The plant is a rich source of bioactive compounds, including steroids, flavonoids, tannins, reducing sugars, belleric acid, bellericoside, chebulinic acid, gallic acid, ethyl gallate, punicalagin, terflavin A, terchebin, luteolin, and tannic acid. These constituents contribute to its diverse pharmacological properties, including antibacterial, antifungal, analgesic, anti-inflammatory, wound-healing, and sunburn-soothing effects. Herbal medicines are the oldest form of health care known to mankind. Gel formulations prepared with Carbopol 940, triethanolamine and Propyl Paraben showed good homogeneity, no skin irritation, good stability and anti-inflammatory activity and gel formulations with varying concentrations of T. chebula extract were prepared and assessed. Among the formulations tested, the 5% concentration demonstrated superior performance across all evaluation parameters. This indicates its potential as an effective and alternative option for therapeutic applications and advanced drug delivery systems.

 

Author (s) Details

 

R. Bhramaramba
Department of Pharmacology and Pharmacognosy, Sir C. R Reddy College of Pharmaceutical Sciences, Eluru, Andhra Pradesh, India.

 

K. Hari Prasath
Department of Pharmacology and Pharmacognosy, Sir C. R Reddy College of Pharmaceutical Sciences, Eluru, Andhra Pradesh, India.

 

Ch. Amulya
Department of Pharmacology and Pharmacognosy, Sir C. R Reddy College of Pharmaceutical Sciences, Eluru, Andhra Pradesh, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/psnid/v1/3774

Formulation and Evaluation of Solid Lipid Nanoparticles-based Gel Containing Miconazole Nitrate (An Antifungal Agent) | Chapter 7 | Advanced Concepts in Pharmaceutical Research Vol. 5

Solid lipid nanoparticles are the advanced drug delivery system in which the active ingredient is incorporated into a lipid carrier (e.g. Triglycerides, fatty acid, steroids, partial glycerides, and waxes) and it is stabilized by using a biocompatible surfactant such as poloxamer, polysorbate, lecithin. The objective of the present investigation was to prepare and evaluate the solid lipid nanoparticle (SLN) based gel using an antifungal agent Miconazole nitrate (MN). Miconazole nitrate was received from Micro Labs Limited, Hosur, HPMC and Carbopol 940, stearic acid, tween 80, glycerol was kindly provided by East Point College of Pharmacy. Compatibility of drug and excipients was confirmed by IR studies. The formulation was prepared by Microemulsion and homogenization method using stearic acid and tween 80.

All the Solid lipid nanoparticle formulations were subjected to particle size, drug entrapment efficiency, scanning electron microscopy and Differential Scanning Calorimetry. Formulation F2 resulted in the least SLN particle size. The F3-SLN dispersion showed a higher entrapment efficiency of 78.7%. Scanning Electron Microscopy of prepared SLN particles showed that prepared particles were spherical and the surface was rough. The Differential Scanning Calorimetry of the SLN particles showed the conversion of the drug from a crystalline to an amorphous state. The prepared SLN particles were dispersed in HPMC Carbopol gel. The resulting SLN-loaded gels were evaluated for appearance, spreadability and in vitro drug release. The SLN-loaded gels showed good appearance and spreadability. The in vitro drug release of SLN gel was evaluated using a Franz diffusion cell using dialysis membrane 70 with phosphate buffer pH 7.4 as a dissolution media. All the formulations showed drug release till 24hrs. It was concluded that Miconazole nitrate-loaded SLN gel formulation containing Carbopol 940 in combination with Hydroxy Propyl Methyl Cellulose was suitable for topical application since it showed prolonged drug release.

Author(s) Details:

V. Chandrakala,
Department of Pharmaceutics, East Point College of Pharmacy, Bidrahalli, Bangalore, India.

H. S. Mamatha,
Department of Pharmaceutics, East Point College of Pharmacy, Bidrahalli, Bangalore, India.

A. Usha,
Department of Pharmaceutics, East Point College of Pharmacy, Bidrahalli, Bangalore, India.

Banu Priya,
Department of Pharmaceutics, East Point College of Pharmacy, Bidrahalli, Bangalore, India.

Please see the link here: https://stm.bookpi.org/ACPR-V5/article/view/13283