Novel Herbal Gel of Kigelia africana(Lam.) Benth, Fruits Extract Formulation and Evaluation | Chapter 2 | Pharmaceutical Science: New Insights and Developments Vol. 5

The whole plant of Kigelia africana(Lam.) Benth. belongs to the Bignoniaceae family and is widely cultivated throughout tropical and subtropical regions of the world, mainly in India and South Africa. Herbal medicine has gained significant global importance due to its medicinal properties and economic value. These herbal medicines have increased; their quality, safety, and efficiency are serious concerns in industrialized and developing countries. The kigelia plant is easily available at river banks and woodlands. The present research has been undertaken with the aim of formulating and evaluating the herbal gel containing Kigelia africana(Lam.) Benth., fruit extract. The Kigelia africana(Lam.) Benth., fruit extract contains Alkaloids, Saponins, Glycosides, Carbohydrates, Tannins, Flavonoids, Proteins, Terpenoids, and Fats. The gel formulation was developed by using Carbopol 940, Kigelia africana(Lam.) Benth., fruit extract, propylene glycol, methyl paraben, propyl paraben, and the required amount of distilled water. The skin pH (6.8-7.1) was maintained by dropwise addition of Triethanolamine. The physicochemical Parameters of formulations (pH, spreadability, Stability, etc.) were determined. Stability studies have been carried out as per ICH guidelines for 3 months at different temperatures and humidity. The results showed that the formulation containing 5% Kigelia africana(Lam.) Benth., fruit extract shows better stability. Further formulations have been studied for skin irritation on the animal model (Rat), and results showed that there was no skin irritation in animals. In conclusion, the studies revealed that the developed single herbal formulation consisting of 5% Kigelia africana(Lam.) Benth., extract comparatively better than the other formulations, but all the formulations were non-irritant and did not show any skin toxicity when applied daily for 7 days in rats. Its antibacterial and antifungal property was not under taken for any scientific study with herbal gel.

 

Author (s) Details

 

R. Bhramaramba
Department of Pharmacology, Sir C R Reddy College of Pharmaceutical Sciences, Eluru, Eluru Dst., Andhra Pradesh, India.

 

A. Narendra Babu
Department of Pharmacology, Sir C R Reddy College of Pharmaceutical Sciences, Eluru, Eluru Dst., Andhra Pradesh, India.

 

T. Nagendra Kumar
Department of Pharmacology, Sir C R Reddy College of Pharmaceutical Sciences, Eluru, Eluru Dst., Andhra Pradesh, India.

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Please see the book here:- https://doi.org/10.9734/bpi/psnid/v5/4761

Novel Herbal Gel Formulation of Terminalia chebula Retz., Plant | Chapter 7 | Pharmaceutical Science: New Insights and Developments Vol. 1

A novel approach was adopted for developing a herbal gel using Terminalia chebula Retz., a plant revered as the "King of Medicine" in Tibetan traditional medicine. This plant thrives in tropical and subtropical regions of East Asia at altitudes of up to 2000 meters, with optimal growth conditions in areas receiving 100–150 cm of annual rainfall and temperatures ranging between 0–17°C. The plant is a rich source of bioactive compounds, including steroids, flavonoids, tannins, reducing sugars, belleric acid, bellericoside, chebulinic acid, gallic acid, ethyl gallate, punicalagin, terflavin A, terchebin, luteolin, and tannic acid. These constituents contribute to its diverse pharmacological properties, including antibacterial, antifungal, analgesic, anti-inflammatory, wound-healing, and sunburn-soothing effects. Herbal medicines are the oldest form of health care known to mankind. Gel formulations prepared with Carbopol 940, triethanolamine and Propyl Paraben showed good homogeneity, no skin irritation, good stability and anti-inflammatory activity and gel formulations with varying concentrations of T. chebula extract were prepared and assessed. Among the formulations tested, the 5% concentration demonstrated superior performance across all evaluation parameters. This indicates its potential as an effective and alternative option for therapeutic applications and advanced drug delivery systems.

 

Author (s) Details

 

R. Bhramaramba
Department of Pharmacology and Pharmacognosy, Sir C. R Reddy College of Pharmaceutical Sciences, Eluru, Andhra Pradesh, India.

 

K. Hari Prasath
Department of Pharmacology and Pharmacognosy, Sir C. R Reddy College of Pharmaceutical Sciences, Eluru, Andhra Pradesh, India.

 

Ch. Amulya
Department of Pharmacology and Pharmacognosy, Sir C. R Reddy College of Pharmaceutical Sciences, Eluru, Andhra Pradesh, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/psnid/v1/3774