Assessment of Brain-derived Neurotrophic Factor (BDNF) Gene Polymorphism in a Patients with Cohort of Egyptian Primary Open-Angle Glaucoma (POAG)| Chapter 1 | Current Overview on Science and Technology Research Vol. 2

 This study was directed to survey the job of the mind determined neurotrophic factor (BDNF) quality poly-morphism (rs2030324) in essential open-point glaucoma (POAG) patients. Essential open-point glaucoma (POAG), the most widely recognized kind, is the second most noteworthy reason for visual deficiency on the planet. An individual from the neurotrophin family, mind inferred neurotrophic factor (BDNF) is delivered by retinal ganglion cells (RGCs). With optic nerve dystrophy, the axonal vehicle of neurotrophins is disturbed, denying the RGCs of BDNF backing and causing glaucomatous retinal cell misfortune.

This case-control study was directed on 50 POAG patients (mean age 55 ± 10) and 50 sound control subjects (mean age 40 ± 11). The two gatherings went through full ophthalmological assessment. Genomic DNA was removed trailed by BDNF rs2030324 genotyping by continuous PCR.

Connection coefficient investigation showed huge positive connection among's age and right and passed on cup to circle proportion (r = 0.448, p = 0.001; r = 0.283, p = 0.004 separately) and critical negative relationship between's intraocular tension and right and left VA (r = - 0.212, p = 0.034; r = - 0.258, p = 0.009 individually). No tremendous distinction between the 2 gatherings was found as respects genotype or alleles recurrence dispersion (p = 0.722).

This study didn't prevail to delineate the job of BDNF quality polymorphism (SNP rs2030324) as a gamble factor for POAG event. The system of glaucoma advancement as indicated by the BDNF polymorphism stays muddled. The review suggest further research of BDNF quality polymorphism SNP rs2030324 on bigger example size and involving DNA sequencing procedures for detec-tion of various BDNF quality polymorphisms and different qualities engaged with the neurodegeneration instrument for better comprehension of the sub-atomic premise of POAG and to track down early indicative markers of POAG improvement.

Author(s) Details:

Mona Fathy,
Department of Ophthalmology, Research Institute of Ophthalmology, Scientific Research Academy, Giza, Egypt.

Arwa M. Darweesh,
Department of Ophthalmology, Research Institute of Ophthalmology, Scientific Research Academy, Giza, Egypt.

Sahar Sharaf,
Department of Ophthalmology, Research Institute of Ophthalmology, Scientific Research Academy, Giza, Egypt.

Hadeel M. El-Hanafi,
Department of Ophthalmology, Research Institute of Ophthalmology, Scientific Research Academy, Giza, Egypt.

Fayek M. Ghaleb,
Department of Ophthalmology, Research Institute of Ophthalmology, Scientific Research Academy, Giza, Egypt.

Iman A. Fahmy,
Department of Ophthalmology, Research Institute of Ophthalmology, Scientific Research Academy, Giza, Egypt.

Shadia M. Hussein,
Department of Ophthalmology, Research Institute of Ophthalmology, Scientific Research Academy, Giza, Egypt.

Please see the link here: https://stm.bookpi.org/COSTR-V2/article/view/7982