With the aid of our computer modelling techniques, the study seeks to alter the prescription drugs now used to treat Alzheimer's disease (AD). The half maximum inhibitory concentration (IC50) value is a measurement used to determine the binding affinity of newly developed medicines to protein molecules associated with Alzheimer's. This number represents the dosage at which a drug must be present in order to block a particular biological process. The predicted updated IC50 values are predicted using two methods. First, the functional graph techniques provide correlations that result in projected IC50 values for the altered drug molecules utilising the energies and the experimentally determined IC50 values.
Author(s) Details:
Nouf Masarweh,
Department of Chemistry, University of Arkansas at Little Rock, Center for Molecular Design and Development, Arkansas, USA.
Jerry A. Darsey,
Department of Chemistry, University of Arkansas at Little Rock, Center for Molecular Design and Development, Arkansas, USA.
Please see the link here: https://stm.bookpi.org/CAPR-V6/article/view/8092
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