Alzheimer's disease (AD) is the most prevalent kind of dementia, characterised by a rapid deterioration in one's ability to retain memories, think coherently, and eventually function independently.
The processes
responsible for maintaining normal protein composition begin to deteriorate
with age, causing several alterations in the human body. The Alzheimer's
Society promotes the advancement of stem cell research in order to better
understand dementia's causes and identify novel treatments. Recent study has
shown that stem cells can increase synaptic strength, microglial activity, angiogenesis,
mitochondrial function, autophagy, and apoptosis in animal models of
Alzheimer's disease.
Based on recent
observations showing neurogenesis decreases drastically in Alzheimer's disease
patients compared to healthy individuals, neural stem cells (NSC) are forming a
new element of disease manifestation. Furthermore, the finding of exosomes
produced from mesenchymal stem cells is regarded as a novel way to
intercellular communication that has provided new insight on the development of
disease-modifying therapeutics for Alzheimer's disease.
Currently, the use
of induced pluripotent stem cells (iPSCs) technology appears to be a potential
method for developing trustworthy models, gaining a better understanding of the
genesis of the pathological process of Alzheimer's disease, and screening
effective anti-AD medications.
Author(S) Details
A. El Shawarby
Department of Histology and Cell Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
S. M. M. Omar
Department of Histology and Cell Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt and Histology Department, Armed Forces College of Medicine, Egypt.
View Book:- https://stm.bookpi.org/ETDHR-V7/article/view/6598
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