This review aims to draw attention to the effects of sodium pyruvate on healthy ageing in comparison to nicotinamide adenine dinucleotide dinucleotide dinucleotide dinucleotide dinucleotide dinucleotide dinucleotide dinucleotide dinucleotide dinucleotide dinucleotide dinucleotide dinucleotide din Healthy ageing has become a study hotspot in life science in recent decades. The level of NAD+ in cells diminishes with ageing and aging-related illnesses, as is well documented. One of the NAD+ precursors was initially demonstrated with its novel involvement in DNA damage repair in mice several years ago, restoring aged mice to their physical state when they were young. Extensive research in animal models and patients is encouraged as a result of the discovery. NAD+ and its antecedents have long been popular in the nutrition industry. Clearing cellular senescence using senolytics, on the other hand, was shown to sustain multiorgan function (kidney and heart) and extend healthy longevity in mice. Following research in elderly patients with idiopathic pulmonary fibrosis supported the findings. In animal and clinical research, senolytic treatment is increasingly being utilised to treat a variety of illnesses. On an equimolar basis, pyruvate, as a NAD+ substitute and a novel senolytic, may be superior to the present items mentioned in preventing and treating illnesses and ageing. Apart from critical care, pyruvate-enriched fluids, particularly pyruvate oral rehydration salt, could be a novel strategy for illnesses and ageing. Despite the lack of direct evidence that pyruvate, as both a NAD+ source and a senolytic agent, helps healthy ageing, more research is needed to compare NAD+ or senolytics for healthy ageing, specifically on an equimolar basis in effective blood levels. From a clinical standpoint, this review compared NAD+ and Senolytics to sodium pyruvate to explore the recognition of healthy ageing.
Author(S) Details
Zhou, Fang-Qiang
Fresenius Medical Care, Dialysis Centers in Chicago, IL., 60008, USA.
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