Pseudomonas aeruginosa Positivity and Sensitivity in Invasive Bloodstream Infections Using Automated Bactec in Tertiary Care Teaching Hospital of North India: A Prospective Observational Study | Chapter 02 | Emerging Trends in Disease and Health Research Vol. 2

 Background: Pseudomonas aeruginosa is a gram-negative aerobic bacillus that is frequently found in the differential diagnosis of a variety of possible hospital-acquired diseases. Pseudomonas aeruginosa-related mortality in bloodstream infections (BSIs) is still a major problem. The goal of this study is to use automated Bactec systems to detect Pseudomonas positive and sensitivity in invasive bloodstream infections, because antibiotic sensitivity profiles fluctuate from one clinical scenario to the next.

The study comprised all blood culture samples obtained in the Department of Microbiology for Bactec Bd fx culture from July 2015 to June 2016. Before they were declared as sterile, the blood culture was examined in the Bactec bd fx system for at least 5 days.

Results: Gram-negative bacteria were found in 931 (73.02 percent) of the 1275 cultures that tested positive for bacteria. Pseudomonas aeruginosa was isolated in 120 (or 12.89 percent) of the 931 cultures that tested positive for gram-negative bacteria. Pseudomonas spp isolates were 100.00 percent sensitive to Colistin, followed by 84.44 percent for Levofloxacin, 82.50 percent for Piperacillin Tazobactum, 77.50 percent for PB, 75.00 percent for Amikacin, and 75.00 percent for Cefepime, while Pseudomonas spp isolates were 90 percent resistant to Ampicillin, followed by 82.64 percent

Conclusion: Pseudomonas aeruginosa is one of the most frequent Gram- Negative organisms, and it is the most commonly isolated bacterium in neonates and infants. Colistin was the most sensitive antibiotic, followed by Levofloxacin, Piperacillin Tazobactum, and Amikacin, while Ampicillin, Ceftazidime, Clavulanic Acid, and Aztreonam were the most resistant antibiotics. To combat the growing threat of antibiotic resistance in this dangerous bacteria, some unique alternative strategies must be devised.

Author(S) Details

Pankaj Katoch
Department of Microbiology, I.G.M.C., Shimla, H.P, India.

Vipin Roach
Department of Pediatrics, I.G.M.C., Shimla, H.P, India.

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